Helicobacter pylori infection in Swiss adolescents

Heuberger, Frank; Pantoflickova, Draha; Gassner, Markus; Oneta, Carl; M, Grehn; Blum, A. L.; Dorta, Gian

doi:10.1097/00042737-200302000-00012

Cited by 23 publications

(26 citation statements)

References 23 publications

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“…Therefore, as was previously reported (11,22,30), the socioeconomic level of children and adolescents is a risk factor for H. pylori infection. Interestingly, 59% of the HpSApositive subjects had a history of either H. pylori infection or peptic ulcer disease in the family, which may indicate the role of interfamilial transmission in H. pylori infection (21).…”

Section: Discussionsupporting

confidence: 55%

“…The rate of infection in children and adolescents from the southwest was significantly higher (70%) than the rate in those from the northwest (32%), and a family history of H. pylori infection or PUD was observed in 59% of the HpSA positive subjects. The HpSA test is a useful test to detect H. pylori infection in children and adolescents from developing countries.Helicobacter pylori infection is acquired mainly in childhood, especially in developing countries (40), where the influence of socioeconomic factors on the prevalence of H. pylori infection has been shown (11,30,37). Many investigators have studied the criteria for diagnosis and treatment of children infected by H. pylori, but association of symptoms with H. pylori infection in children presenting with nonulcer dyspepsia is controversial (3,14,22).…”

mentioning

confidence: 99%

“…Helicobacter pylori infection is acquired mainly in childhood, especially in developing countries (40), where the influence of socioeconomic factors on the prevalence of H. pylori infection has been shown (11,30,37). Many investigators have studied the criteria for diagnosis and treatment of children infected by H. pylori, but association of symptoms with H. pylori infection in children presenting with nonulcer dyspepsia is controversial (3,14,22).…”

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confidence: 99%

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Application of a Stool Antigen Test To Evaluate the Incidence ofHelicobacter pyloriInfection in Children and Adolescents from Tehran, Iran

Falsafi

Valizadeh

Sepehr

et al. 2005

Clin Vaccine Immunol

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Helicobacter pylori infection is acquired mainly in childhood, especially in developing countries, where a low-cost, rapid diagnostic technique which is reliable for all age groups may be useful for the management of H. pylori infection. For this purpose, we used an HpSA test (Equipar) to detect H. pylori infection in children and adolescents from Tehran, Iran. Thirty-five children who were positive or negative for H. pylori infection by endoscopy-based tests were used as positive and negative controls for the HpSA test. Stools were collected from 430 randomly selected children and adolescents (4 to 18 years old) from southwest, near the center, and northwest of Tehran. A questionnaire that included presence of recurrent abdominal pain (RAP), family history of infection and/or peptic ulcer disease (PUD), and income of parents was completed. A good agreement was found between the results of endoscopy-based tests and those of the HpSA test; the sensitivity and specificity of the Equipar-HpSA test were 100% and 83.4%, respectively. Among 430 children and adolescents, 47% were positive by the HpSA test, of whom 82% had RAP. No difference in incidence was observed between the two sexes; the various categories of age showed an increasing incidence, ranging from 24% (ages 4 to 6) to 58% (ages 16 to 18). The rate of infection in children and adolescents from the southwest was significantly higher (70%) than the rate in those from the northwest (32%), and a family history of H. pylori infection or PUD was observed in 59% of the HpSA positive subjects. The HpSA test is a useful test to detect H. pylori infection in children and adolescents from developing countries.Helicobacter pylori infection is acquired mainly in childhood, especially in developing countries (40), where the influence of socioeconomic factors on the prevalence of H. pylori infection has been shown (11,30,37). Many investigators have studied the criteria for diagnosis and treatment of children infected by H. pylori, but association of symptoms with H. pylori infection in children presenting with nonulcer dyspepsia is controversial (3,14,22). One important controversy relates to the presence of recurrent abdominal pain (RAP) in children, where an important association was observed between RAP and H. pylori infection in some populations (4,10,19,27,28,31,34). Although endoscopy-based tests are the best methods to diagnose active H. pylori infection, their application in children is more difficult and unpleasant than in adults. Moreover, in developing regions, for socioeconomic reasons, most infected children are not diagnosed and/or treated for H. pylori infection. To circumvent these difficulties, a noninvasive test with reliability for all age groups of children and adolescents is required. Among the noninvasive methods, serological tests cannot be applied to young children because of low sensitivity. In addition, the 13 C urea breath test is cumbersome, expensive, and consequently unavailable in certain countries; furthermore, it is not reliable in very...

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Section: Discussionsupporting

confidence: 55%

mentioning

confidence: 99%

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confidence: 99%

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Application of a Stool Antigen Test To Evaluate the Incidence ofHelicobacter pyloriInfection in Children and Adolescents from Tehran, Iran

Falsafi

Valizadeh

Sepehr

et al. 2005

Clin Vaccine Immunol

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“…Moreover, It has been reported that children in Gambia and Nigeria are almost all infected by H pylori at age of 5 years [19,20] . On the other hand, Heuberger et al [21] reported the prevalence of H pylori infection among adolescents between 15-16 years of age, living in Switzerland. They found one of the lowest prevalence of H pylori infection among adolescents in Europe (7.3%).…”

Section: Discussionmentioning

confidence: 99%

Specific serum immunoglobulin G to H pylori and CagA in healthy children and adults (south-east of Iran)

Jafarzadeh¹,

Rezayati²,

Nemati³

2007

WJG

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AIM:To evaluate the serologic IgG response to H pylori and CagA across age groups and in healthy children and adults. METHODS:Totally, 386 children aged 1-15 years and 200 adults aged 20-60 years, were enrolled to study. The serum samples of participant were tested for presence of anti-H pylori and anti-CagA IgG by using ELISA method. RESULTS:The seroprevalence of H pylori in adults was significantly higher than that observed in children (67.5% vs 46.6%; P < 0.000003). In children, the seropositivity rate in males (51.9%) was significantly (P < 0.05) higher than that observed in females (41.7%). The prevalence of serum anti-CagA antibody was 72.8% and 67.4% in infected children and adults, respectively. The mean titer of serum anti-CagA antibodies was significantly higher among children in comparison to adults (64.1 Uarb/mL vs 30.7; P < 0.03). In infected children and adults the prevalence of serum anti-CagA antibody was higher in males compared to females (78.4% vs 66.3%; P = 0.07 and 75.6% vs 54.71%; P < 0.04, respectively). The age-specific prevalence of anti-H pylori and anti-CagA antibody (in infected subjects) was 37.6% and 59.57% at age 1-5 years, 46.9% and 75% at age 6-10 years, 54.9% and 79.45% at age 11-15, 59.01% and 83.33% at age 20-30 years, 66.6% and 60.52% at age 31-40 years, 73.46% and 63.88% at age 41-50 years and 75.75% and 60% at age 51-60 years with mean titer of anti-CagA antibody of 75.94, 63.32, 57.11, 52.06, 23.62, 21.52 and 21.80 Uarb/mL, respectively. There was significant difference between mean serum anti-CagA antibody in age subgroups (P < 0.001). CONCLUSION:These results showed that anti-H pylori and anti-CagA antibodies were common in the children and adults. The H pylori -specific antibodies influenced by age and sex of subjects. Moreover, it seems that males are more susceptible to infection with CagA + strains compared to females. The seroprevalence of anti-CagA antibody was increased with age, up to 30 years and then decreased. It was also found that the magnitude of the IgG response to CagA decreased with advanced age.

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“…In our village of Grabs the seroreactivity of H. pylori showed a distinct correlation with the origin of the mother, especially when she came from south-east Europe. This can explain the low prevalence of hay fever in children from migrant populations in spite of a lack of exposure to domestic animals [16] .…”

Section: The Paradox Of Organ Distributionmentioning

confidence: 99%

Helicobacter pylori infection in Swiss adolescents

Cited by 23 publications

References 23 publications

Application of a Stool Antigen Test To Evaluate the Incidence ofHelicobacter pyloriInfection in Children and Adolescents from Tehran, Iran

Application of a Stool Antigen Test To Evaluate the Incidence ofHelicobacter pyloriInfection in Children and Adolescents from Tehran, Iran

Specific serum immunoglobulin G to H pylori and CagA in healthy children and adults (south-east of Iran)

Farmers and Their Environment: Protective Influences of the Farming Environment against the Development of Allergies

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