Helicobacter pylori infection is not related to increased carotid intima-media thickness in general population

Feng, Yangbo; Zhou, Weibin; Luo, Luo; Xu, Weiwei

doi:10.1038/s41598-018-32465-4

Cited by 12 publications

(20 citation statements)

References 29 publications

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“…Thus, a negative association was observed for female sex, while a positive association was observed for age and SBP. HDL-C appeared also as an independent factor negatively related to IMT-CC, which had been previously observed and related to its antioxidant activitiy 37 . We also observed the use of diuretics as an independent positive contributor though it did not correlated with serum Mg, which does not agree with the findings reported in the Atherosclerosis Risk in Communities Study (ARIC) cohort reporting that higher serum Mg levels associated to lower prevalence of diuretic use 7 .…”

Section: Discussionsupporting

confidence: 75%

Serum Magnesium is associated with Carotid Atherosclerosis in patients with high cardiovascular risk (CORDIOPREV Study)

Rodríguez‐Ortiz

Gómez-Delgado

Larriva

et al. 2019

Sci Rep

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This study aimed to ascertain whether there is an independent association between serum magnesium (Mg) and the Carotid Intima-Media Thickness (IMT-CC), a well-accepted atherosclerotic-biomarker surrogate of cardiovascular disease (CVD), in a population with high cardiovascular risk. Serum Mg and traditional atherosclerotic risk factors were recorded in 939 patients (mean age, 59.6 ± 0.3 years, 83.2% men) with coronary heart disease (CHD) enrolled in the CORDIOPREV trial. Serum Mg strongly associated with IMT-CC. Before adjusting for potential confounding factors, IMT-CC decreased by 0.111 ± 0.011 mm per mg/dl increase in serum Mg ( p < 0.001). After adjustment, the effect of Mg did not appear mediated through factors related to glucose metabolism, the lipid profile or the mineral metabolism and renal function. Multivariate models showed the lower Mg levels (quartile 1) as a strong independent factor contributing to IMT-CC along with age, sex, SBP, HDL-C, and diuretic use. Logistic regression analysis confirmed the predictive ability of serum Mg to differentiate patients at higher atherosclerotic risk as defined by an IMT-CC ≥ 1.0 mm, yielding a OR for the lower quartile of 10.623 (95%CI 2.311–48.845; P = 0.002) and a ROC-derived cutoff of 1.61 mg/dl. Therefore, our findings outline low serum magnesium as a possible independent risk factor for carotid atherosclerosis.

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Section: Discussionsupporting

confidence: 75%

Serum Magnesium is associated with Carotid Atherosclerosis in patients with high cardiovascular risk (CORDIOPREV Study)

Rodríguez‐Ortiz

Gómez-Delgado

Larriva

et al. 2019

Sci Rep

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“…A cross-sectional study of 13,770 general population found that after adjusting for a variety of factors, there is almost no evidence that there is an association between H. pylori and CIMT. 61 In contrast, a small sample size study found that positive H. pylori was associated with an increase in CIMT and believed that H. pylori might play a role in the process of AS. 32 At the same time, Jin Huashan (2018)…”

Section: F I G U R E 3 Meta-analysis Results Of Cimt Related Literatu...mentioning

confidence: 96%

“…What needs attention is that for every 100 mm increase in the absolute value of CIMT, the probability of stroke will increase by 13% to 18%, and the probability of myocardial infarction will increase by 10% to 15% in the future. A cross‐sectional study of 13,770 general population found that after adjusting for a variety of factors, there is almost no evidence that there is an association between H. pylori and CIMT 61 . In contrast, a small sample size study found that positive H. pylori was associated with an increase in CIMT and believed that H. pylori might play a role in the process of AS 32 .…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori infection and the progression of atherosclerosis: A systematic review and meta‑analysis

Shi

Dong

et al. 2021

Helicobacter

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Objective: In recent years, many studies have tried to prove whether Helicobacter pylori (H. pylori) can promote the progression of atherosclerosis (AS), but the reported results are conflicting. Carotid intima-media thickness (CIMT), flow-mediated dilation (FMD), or pulse wave velocity (PWV) are the most commonly used indicators to evaluate the progress of AS. So, we collected and evaluated these three indicators to provide evidence-based medicine for the clinic. Materials and methods:We included and evaluated studies on H. pylori infection and CIMT, FMD, or PWV from PubMed, Cochrane trials, and Embase databases before September 1, 2021, and language restrictions: English. Research types include crosssectional studies, cohort studies, and case-control studies. The MINORS scale was used to evaluate the quality of these studies. For all studies, we choose a randomeffects model and calculate the weighted mean difference (WMD) for analysis, and all our analyses use STATA software.Results: Meta-analysis shows that H. pylori infection can significantly increase CIMT (WMD = 0.059, 95% CI: 0.039, 0.079, p < 0.001). Based on subgroup analysis, we found that the relationship between the two is more significant in the young and middle-aged people younger than 60 years old and people without cardiovascular disease. In addition, we also found an association between H. pylori infection and FMD (WMD = −3.873, 95% CI: −5.684, −2.062, p < 0.001), but it is a pity that there are few literatures that meet the standards. Finally, We concluded that H. pylori infection can significantly increase PWV (WMD = 88.033, 95%CI: 67.297,108.768. I 2 = 99.63%, p < 0.001). In the subgroup analysis, we also found that this correlation is similar to CIMT, and it is more significant in the young and middle-aged population under 60 and those without cardiovascular disease. We also found in the sub-analysis that there was a significant increase in CIMT in CagA-positive individuals in H. pylori-infected patients (WMD = 0.16, 95%CI: 0.02, 0.29. p = 0.03). Conclusion:Helicobacter pylori infection can promote the process of AS, especially in people under the age of 60 and people without cardiovascular risk factors, and we hope that our meta-analysis can provide ideas for the early prevention of AS.

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“…The etiology of atherosclerosis is complex. In addition to the identified risk factors, studies have proposed that HP infection may be a risk factor for CAS, but some researchers still hold the opposite opinion ( 5 , 22 , 23 ). We conducted a cross-sectional study of 1,424 subjects in Jidong from 2014 to 2015 to explore the association between HP and CAS.…”

Section: Discussionmentioning

confidence: 99%

“…Although it colonizes the digestive tract, increasing evidence has shown that HP is associated with extragastric diseases such as CVD. However, some researchers have different perspectives on the existence of an association between HP and CAS ( 5 ). This is a controversial topic in epidemiological, pathological, and clinical studies ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Association of Helicobacter pylori Infection With Carotid Atherosclerosis in a Northern Chinese Population: A Cross-Sectional Study

Zhang

Song

Wang

et al. 2022

Front. Cardiovasc. Med.

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Numerous studies have shown that Helicobacter pylori (HP) infection may be involved in the development of carotid atherosclerosis (CAS), but this conclusion is still controversial. The aim of this study was to explore whether there is a positive association between HP infection and CAS occurrence. We collected data on demographic characteristics, lifestyle, and disease history of the participants by questionnaire. We obtained clinical anthropometric data and blood samples of the participants from clinical examinations and laboratory work. The 13C urea breath test (13C-UBT) was performed to assess the HP infection status, and carotid ultrasonography was used to diagnose the CAS and plaque types. Univariate analysis and multivariate logistic regression were used to identify the relationship between HP infection and CAS. A total of 1,424 participants were recruited for this study. A total of 740 HP-positive individuals and 684 HP-negative individuals were identified, and 345 participants were diagnosed with CAS. The prevalence of CAS was higher in the HP-positive group (26.4%) than in the HP-negative group (21.7%) (P < 0.05). A significantly higher prevalence of carotid intima-media thickening, carotid plaque, and carotid stenosis was identified in the HP-positive group than in the HP-negative group (P < 0.05). There was no significant difference in the detection rate of unstable plaques between the HP-positive and HP-negative groups (P > 0.05). In multivariate models adjusted for covariates, HP infection showed a positive association with CAS, independent of other risk factors (ORs range: 1.283–1.333, P < 0.05). HP infection independently accounted for approximately 5% of the CAS risk in the absence of other cardiovascular risk factors. A positive association between HP infection and CAS was demonstrated in this study. HP infection might be an independent risk factor for CAS. Although the effect of HP infection on CAS observed in our study was less than that of traditional risk factors, we believe that this is an indispensable advance in the etiological study of CAS. These results imply that the microbial population might play an essential role in CAS, which provides a new perspective for the primary prevention of CAS.

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Helicobacter pylori infection is not related to increased carotid intima-media thickness in general population

Cited by 12 publications

References 29 publications

Serum Magnesium is associated with Carotid Atherosclerosis in patients with high cardiovascular risk (CORDIOPREV Study)

Serum Magnesium is associated with Carotid Atherosclerosis in patients with high cardiovascular risk (CORDIOPREV Study)

Helicobacter pylori infection and the progression of atherosclerosis: A systematic review and meta‑analysis

Association of Helicobacter pylori Infection With Carotid Atherosclerosis in a Northern Chinese Population: A Cross-Sectional Study

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