Helicobacter pylori infection and the progression of atherosclerosis: A systematic review and meta‑analysis

Abstract

Objective: In recent years, many studies have tried to prove whether Helicobacter pylori (H. pylori) can promote the progression of atherosclerosis (AS), but the reported results are conflicting. Carotid intima-media thickness (CIMT), flow-mediated dilation (FMD), or pulse wave velocity (PWV) are the most commonly used indicators to evaluate the progress of AS. So, we collected and evaluated these three indicators to provide evidence-based medicine for the clinic. Materials and methods:We included and evaluated studies on H. pylori infection and CIMT, FMD, or PWV from PubMed, Cochrane trials, and Embase databases before September 1, 2021, and language restrictions: English. Research types include crosssectional studies, cohort studies, and case-control studies. The MINORS scale was used to evaluate the quality of these studies. For all studies, we choose a randomeffects model and calculate the weighted mean difference (WMD) for analysis, and all our analyses use STATA software.Results: Meta-analysis shows that H. pylori infection can significantly increase CIMT (WMD = 0.059, 95% CI: 0.039, 0.079, p < 0.001). Based on subgroup analysis, we found that the relationship between the two is more significant in the young and middle-aged people younger than 60 years old and people without cardiovascular disease. In addition, we also found an association between H. pylori infection and FMD (WMD = −3.873, 95% CI: −5.684, −2.062, p < 0.001), but it is a pity that there are few literatures that meet the standards. Finally, We concluded that H. pylori infection can significantly increase PWV (WMD = 88.033, 95%CI: 67.297,108.768. I 2 = 99.63%, p < 0.001). In the subgroup analysis, we also found that this correlation is similar to CIMT, and it is more significant in the young and middle-aged population under 60 and those without cardiovascular disease. We also found in the sub-analysis that there was a significant increase in CIMT in CagA-positive individuals in H. pylori-infected patients (WMD = 0.16, 95%CI: 0.02, 0.29. p = 0.03). Conclusion:Helicobacter pylori infection can promote the process of AS, especially in people under the age of 60 and people without cardiovascular risk factors, and we hope that our meta-analysis can provide ideas for the early prevention of AS.

Effect of polyphenol compounds onHelicobacter pylorieradication: a systematic review with meta-analysis

“…Infection with H.pylori is a major pathogenic factor for superficial gastritis, chronic atrophic gastritis, duodenal or gastric ulcers and gastric mucosa-associated lymphoid tissue lymphoma. 38 It has also been linked with several extra-digestive diseases such as atherosclerosis, 39 coronary heart disease, 40 iron deficiency anaemia, 41 idiopathic thrombocytopenic purpura, 42 vitamin B12 deficiency, 43 non-alcoholic fatty liver disease, 44 metabolic syndrome, 45 diabetes mellitus, 46 cerebrovascular disease, 47 Alzheimer’s disease, 48 Parkinson’s disease, 49 childhood asthma, 50 chronic obstructive pulmonary disease, 51 chronic urticaria, 52 rosacea 53 and osteoporosis. 54 H. pylori eradication is required for managing H. pylori -related complications.…”

Helicobacter Pylori Virulence Factor Cytotoxin-Associated Gene A (CagA) Induces Vascular Calcification in Coronary Artery Smooth Muscle Cells

“…Patients with angina pectoris have higher titers of anti-CagA antibodies compared to healthy controls [ 21 ]. Meta-analyses show an increased risk of atherosclerosis [ 26 ] as well as cardiovascular diseases, e.g., ischemic stroke and myocardial infarction, among H. pylori -positive subjects [ 20 , 27 ]. H. pylori -specific DNA has been detected in coronary atherosclerotic plaques [ 28 ].…”

Qige Huxin Formula Attenuates Isoprenaline-Induced Cardiac Fibrosis in Mice via Modulating Gut Microbiota and Protecting Intestinal Integrity

“…QHF consumption significantly increased the relative abundance of Bacteroides and Mucispirillum in mice feces, while it decreased the relative abundance of Escherichia-Shigella . Several studies have shown that microbiota with low Bacteroides abundance or high Helicobacter abundance can increase the risk of cardiovascular diseases [ 44 , 45 ]. In this study, QHF treatment significantly increased the relative abundances of Marvinbryantia and Phascolarctobacterium at the genus level.…”