Helicobacter pylori infection reduces TAMs infiltration in a mouse model of AOM/DSS induced colitis-associated cancer

Li, Luo-na; Liu, Yun; Zhang, Hong-chen; Wu, Ting; Dai, Yun; Wang, Weihong

doi:10.1371/journal.pone.0241840

Cited by 8 publications

(7 citation statements)

References 27 publications

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“…Although most studies have focused on tumor-causing bacterial species, some bacterial species can slow down the progression of tumors through promotion of the immune response. Helicobacter pylori infection reduced the infiltration of M2 TAMs into CAC tumors and downregulated the expression of pro-inflammatory and protumorigenic factors such as TNF-α, IL-1β, IL-6, and IL-23 in the tumors of CAC mice [134].…”

Section: Crosstalk Between Macrophages and The Microbiota In Crcmentioning

confidence: 94%

Tumor-Associated Macrophages (TAMs) in Colorectal Cancer (CRC): From Mechanism to Therapy and Prognosis

Wang

Tian

Zhang

2021

IJMS

199

104

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Colorectal cancer (CRC) is a malignant tumor in the digestive system whose incidence and mortality is high-ranking among tumors worldwide. The initiation and progression of CRC is a complex process involving genetic alterations in cancer cells and multiple factors from the surrounding tumor cell microenvironment. As accumulating evidence has shown, tumor-associated macrophages (TAMs)—as abundant and active infiltrated inflammatory cells in the tumor microenvironment (TME)—play a crucial role in CRC. This review focuses on the different mechanisms of TAM in CRC, including switching of phenotypical subtypes; promoting tumor proliferation, invasion, and migration; facilitating angiogenesis; mediating immunosuppression; regulating metabolism; and interacting with the microbiota. Although controversy remains in clinical evidence regarding the role of TAMs in CRC, clarifying their significance in therapy and the prognosis of CRC may shed new light on the optimization of TAM-centered approaches in clinical care.

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Section: Crosstalk Between Macrophages and The Microbiota In Crcmentioning

confidence: 94%

Tumor-Associated Macrophages (TAMs) in Colorectal Cancer (CRC): From Mechanism to Therapy and Prognosis

Wang

Tian

Zhang

2021

IJMS

199

104

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“…[ 24 ] A recent preclinical study on serum exosomes derived from H. pylori -positive gastritis patients showed a potential explanatory pathway for the inverse phenomenon. [ 25 ] Other animal studies suggested regulatory T (Treg) cells, [ 26 ] T-helper (Th17) cells, [ 26 ] regulatory B (Breg) cells, [ 27 ] and M2 macrophages [ 28 ] might make a positive effect on the protective function of H. pylori infection for colitis. In addition, the luminal delivery of H. pylori genomic DNA ameliorates the severity of chronic experimental colitis.…”

Section: Global Epidemiological Trends Of Ibd and H Pylori ...mentioning

confidence: 99%

Helicobacter pylori may participate in the development of inflammatory bowel disease by modulating the intestinal microbiota

Bai

Jiang

Ruan

et al. 2022

Chinese Medical Journal

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Inflammatory bowel disease (IBD) is a non-specific inflammatory disease of the gastrointestinal (GI) tract that is generally accepted to be closely related to intestinal dysbiosis in the host. GI infections contribute a key role in the pathogenesis of IBD; however, although the results of recent clinical studies have revealed an inverse correlation between Helicobacter pylori (H. pylori) infection and IBD, the exact mechanism underlying the development of IBD remains unclear. H. pylori, as a star microorganism, has been a focus for decades, and recent preclinical and real-world studies have demonstrated that H. pylori not only affects the changes in the gastric microbiota and microenvironment but also influences the intestinal microbiota, indicating a potential correlation with IBD. Detailed analysis revealed that H. pylori infection increased the diversity of the intestinal microbiota, reduced the abundance of Bacteroidetes, augmented the abundance of Firmicutes, and produced short-chain fatty acid-producing bacteria such as Akkermansia. All these factors may decrease vulnerability to IBD. Further studies investigating the H. pylori-intestinal microbiota metabolite axis should be performed to understand the mechanism underlying the development of IBD.

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“…H. pylori infection has been reported to play a key role in GC ( 21 , 22 ) and has been found to relate to macrophage infiltration in a mouse model ( 19 ). Therefore, we hypothesized that the infiltration of TAMs in cancer may be related to H. pylori infection.…”

Section: Resultsmentioning

confidence: 99%

“…It was previously reported that H. pylori urease-activated mucosal macrophages can produce proinflammatory cytokines, which result in H. pylori -related mucosal inflammation ( 18 ). In mice with colitis-associated cancer, H. pylori infection was found to reduce TAM infiltration, especially the infiltration of M2-like TAMs ( 19 ). Che et al also demonstrated that H. pylori infection-induced upregulation of activated mesenchymal–epithelial transition factor in exosomes influences the tumor-promoting effect of TAMs ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

The Distinct Impact of TAM Infiltration on the Prognosis of Patients With Cardia and Non-Cardia Gastric Cancer and Its Association With H. pylori Infection

et al. 2021

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BackgroundIn stage III gastric cancer (GC), the role of tumor-associated macrophages (TAMs) and Helicobacter pylori (H. pylori) infection impact tumor progression; however, the specific mechanisms remain controversial. We speculated whether this controversy is caused by differences in the location of TAM infiltration (in the core (CT) and invasive margin (MI) of primary tumors) and the topographical subsites of GC (cardia and non-cardia). Therefore, in this study, we investigated TAMs in different locations and H. pylori infection status as prognostic biomarkers for GC.MethodsImmunohistochemical staining for CD68 (pan-macrophage), CD163 (M2-like macrophage), and H. pylori in 200 samples (100 cases of cardia-GC [CGC] and 100 cases of non-cardia GC [NCGC]) was performed. We compared the number of CD68+ and CD163+ macrophages that infiltrated the CT and MI in patients with the prognosis of CGC and NCGC, respectively. In addition, we analyzed the relationship between H. pylori status and the prognosis of patients with GC in different locations, as well as the correlation with TAM infiltration.ResultsThe distribution of TAMs had distinct characteristics in CGC and NCGC, especially differences between CT and MI subtype. A Kaplan–Meier analysis showed that a high number of CD68+ macrophages that infiltrated the CT in CGC was associated with a better prognosis, whereas infiltration at the MI in NCGC indicated a poor prognosis. Furthermore, a high number of CD163+ macrophages infiltrating the MI resulted in a poor prognosis in CGC and NCGC cohorts. Considering the larger differences in the relationship between the infiltration of CD68+ macrophages at different locations and prognosis, we divided the GC cases into marginal and central GC, based on this difference. This resulted in an accurate estimation of the prognosis. Moreover, positive H. pylori status in central GC was significantly associated with a better prognosis and TAM infiltration.ConclusionTAMs in different locations and H. pylori status were identified as independent prognostic markers, with an obvious correlation between them. Therefore, it is important to clarify the impact of TAM location on the prognosis of patients with GC, which contributes to the development of potential therapeutic strategies.

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Helicobacter pylori infection reduces TAMs infiltration in a mouse model of AOM/DSS induced colitis-associated cancer

Cited by 8 publications

References 27 publications

Tumor-Associated Macrophages (TAMs) in Colorectal Cancer (CRC): From Mechanism to Therapy and Prognosis

Tumor-Associated Macrophages (TAMs) in Colorectal Cancer (CRC): From Mechanism to Therapy and Prognosis

Helicobacter pylori may participate in the development of inflammatory bowel disease by modulating the intestinal microbiota

The Distinct Impact of TAM Infiltration on the Prognosis of Patients With Cardia and Non-Cardia Gastric Cancer and Its Association With H. pylori Infection

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