Helicobacter pylori Interference with Micronutrients and Orally AdministeredDrugs:ANewMechanism Explaining its Role in Extragastric Disorders

Abstract

There is an increasing evidence that Helicobacter pylori may interfere with gastrointestinal metabolism of micronutrients and drugs such as iron, cobalamin, thyroxine and levodopa, with relevant clinical effects. In this review we examine the strength of the causal association and the plausible pathophysiologic mechanisms underlying these adverse effects.

III Conferencia Española de Consenso sobre la infección por Helicobacter pylori

“…Se ha apuntado que la infección por H. pylori puede causar malabsorción de diferentes micronutrientes 115 . Más concretamente, se ha señalado que aun sin ser la causa principal, H. pylori puede producir un déficit de vitamina B12 116---118 .…”

Micronutrients (Other than iron) and Helicobacter pylori Infection: A Systematic Review

“…Previous narrative reviews have focused on the question of the influence of H. pylori infection on micronutrient deficiencies reporting limited data on vitamin B 12 , vitamin A, and ascorbic acid [6,7,[18][19][20][21]. More recently, meta-analyses have been performed reporting a positive association between H. pylori infection and iron deficiency anemia and a positive effect of eradication treatment on iron deficiency and anemia [22][23][24][25][26].…”

In-vitro interaction of l-dopa with bacterial adhesins of Helicobacter pylori: an explanation for clinicial differences in bioavailability?

“…Pierantozzi et al 8–10 already postulated a correlation of reduced l ‐dopa plasma levels in Parkinson's disease patients with the presence of H. pylori , being normalized after H. pylori eradication. The data from the present in‐vitro investigations clearly indicate a dose‐ and bacteria‐dependent interaction of l ‐dopa with H. pylori , leading to a decreased concentration of l ‐dopa in the incubation supernatant.…”

“…The colonisation of the stomach by H. pylori can change the mucosal status and therefore also the mucous layer, the epithelium and the respective functionalities of the tissue. Especially, the interference of H. pylori with micronutrients and orally administered drugs is becoming a major focus of pharmacokinetic research (for review see references 8 ).…”