Helicobacter pylori Outer Membrane Vesicles and Extracellular Vesicles from Helicobacter pylori-Infected Cells in Gastric Disease Development

González, María Fernanda; Díaz, Paula; Sandoval-Bórquez, Alejandra; Herrera, Daniela; Quest, Andrew F. G.

doi:10.3390/ijms22094823

Cited by 35 publications

(38 citation statements)

References 186 publications

(289 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…H. pylori peptidoglycan delivered into host cells by the T4SS is recognized by epithelial cells via Nod1 [72], leading to NF-κB activation and the production of β-defensin and type I IFNs from Nod1-activated gastric epithelial cells [73][74][75]. H. pylori can secrete outer membrane vesicles (OMVs) separated from the bacterial outer membrane [76]. OMVs containing peptidoglycan enter epithelial cells at cholesterol-rich lipid rafts and induce NOD1-dependent response [77].…”

Section: Pamps Derived From H Pylori Inducingmentioning

confidence: 99%

Immunological Perspective: Helicobacter pylori Infection and Gastritis

Yang

2022

Mediators of Inflammation

View full text Add to dashboard Cite

Helicobacter pylori is a spiral-shaped gram-negative bacterium. Its infection is mainly transmitted via oral-oral and fecal-oral routes usually during early childhood. It can achieve persistent colonization by manipulating the host immune responses, which also causes mucosal damage and inflammation. H. pylori gastritis is an infectious disease and results in chronic gastritis of different severity in near all patients with infection. It may develop from acute/chronic inflammation, chronic atrophic gastritis, intestinal metaplasia, dysplasia, and intraepithelial neoplasia, eventually to gastric cancer. This review attempts to cover recent studies which provide important insights into how H. pylori causes chronic inflammation and what the characteristic is, which will immunologically explain H. pylori gastritis.

show abstract

Section: Pamps Derived From H Pylori Inducingmentioning

confidence: 99%

Immunological Perspective: Helicobacter pylori Infection and Gastritis

Yang

2022

Mediators of Inflammation

View full text Add to dashboard Cite

show abstract

“…About a hundred different proteins are found, including several H. pylori virulence factors, such as VacA, CogA, urease, and catalase (KatA). 75,89,90 H. pylori OMVs carry VacA and can deliver the active toxin to epithelial cells to stimulate proliferation, IL-8 secretion, vacuolation, and cell apoptosis. 91,92 KatA is an antioxidant enzyme and enriched in the surface of OMVs.…”

Section: Role Of Omvs In Helicobacter Pylori Infectionmentioning

confidence: 99%

“…Since EVs are a nanocarrier of molecules from pathogens and pathogen-infected cells, González and colleagues proposed a hypothesis that EVs released from H. pylori-infected gastric epithelial cells can enter the blood and reach other tissues, resulting in extragastric diseases. 75 In particular, the EVs from H. pylori-infected cells may encapsulate the H. pylori virulence factors and AS-associated microRNAs (miRNAs).…”

Section: Extracellular Vesicles (Evs) From Helicobacter Pylori-infect...mentioning

confidence: 99%

“…Zavan and colleagues suggested that OMVs have a mechanism for cargo selection depending on their growth stage. 75,93 OMVs can enhance bacterial defense against host innate immune attacks, which will allow H. pylori to escape toward nearby infection sites with lower ROS, thereby facilitating bacterial survival and colonization. 90 Moreover, the H. pylori OMVs are an important component of H. pylori biofilm and have some role in biofilm formation.…”

Section: Role Of Omvs In Helicobacter Pylori Infectionmentioning

confidence: 99%

See 1 more Smart Citation

Extracellular vesicles from helicobacter pylori‐infected cells and helicobacter pylori outer membrane vesicles in atherosclerosis

Qiang

Tian

et al. 2022

Helicobacter

View full text Add to dashboard Cite

Background The role of H. pylori infection has been reported in various extragastric diseases, particularly, the correlation between H. pylori and atherosclerosis (AS) have received lots of attention. Some scholars demonstrated that the presence of H. pylori‐specific DNA in the sclerotic plaques of atheromatous patients provides biological evidences, with indicating that H. pylori infection is a potential factor of AS. However, the underlying mechanism of H. pylori or their products cross the epithelial barriers to enter the blood circulation remains unclear. Recent studies have shown that the extracellular vesicles (EVs) derived from H. pylori‐infected gastric epithelial cells encapsulated H. pylori virulence factor cytotoxin‐associated gene A (CagA) and existed in the blood samples of patients or mice, which indicating that they can carry CagA into the blood circulation. Based on these findings, some researchers proposed a hypothesis that H. pylori is involved in the pathogenesis of AS via EVs‐based mechanisms. In addition, outer membrane vesicles (OMVs) serve as transport vehicles to deliver H. pylori virulence factors to epithelial cells. It is necessary to discuss the role of H. pylori OMVs in the development of AS. Objectives This review will focus on the correlation between H. pylori infection and AS and tried to unveil the possible role of EVs from H. pylori‐infected cells and H. pylori OMVs in the pathogenesis of AS, with a view to providing help in refining our knowledge in this aspect. Methods All of information included in this review was retrieved from published studies on H. pylori infection in AS. Results H. pylori infection may be an atherosclerotic risk factor and drives researchers to reevaluate the role of H. pylori in the pathogenesis of AS. Some findings proposed a new hypothesis that H. pylori may be involved in the pathogenesis of AS through EVs‐based mechanisms. Besides EVs from H. pylori‐infected cells, whether H. pylori OMVs may play some role in the pathogenesis of AS is still remain unclear. Conclusion Existing epidemiological and clinical evidence had shown that there is a possible association between H. pylori and AS. However, except for the larger randomized controlled trials, more basic research about EVs from H. pylori‐infected cells and H. pylori OMVs is the need of the hour to unveil the possible role of H. pylori infection in the pathogenesis of AS.

show abstract

“…Future studies should determine and characterize the sRNAs present in OMV's from Fusobacterium nucleatum, to establish possible biological effects in hosts. Importantly, it was suggested that OMVs from H pylori could be implicated in gastric cancer development [119]; however, it is not known the role of OMVs from Fusobacterium nucleatum in the context of cancer. Thus, signaling by sRNA packed in OMVs and transported out of bacteria associated with cancer must be addressed, since knowledge in this area is lacking and presents potential clinical applications as delivering vectors combined with possible small RNA based therapy.…”

Section: Importance Of the Identification And Characterization Of Small Rnas In Bacteriamentioning

confidence: 99%

MicroRNAs Encoded by Virus and Small RNAs Encoded by Bacteria Associated with Oncogenic Processes

et al. 2021

View full text Add to dashboard Cite

Cancer is a deadly disease and, globally, represents the second leading cause of death in the world. Although it is a disease where several factors can help its development, virus induced infections have been associated with different types of neoplasms. However, in bacterial infections, their participation is not known for certain. Among the proposed approaches to oncogenesis risks in different infections are microRNAs (miRNAs). These are small molecules composed of RNA with a length of 22 nucleotides capable of regulating gene expression by directing protein complexes that suppress the untranslated region of mRNA. These miRNAs and other recently described, such as small RNAs (sRNAs), are deregulated in the development of cancer, becoming promising biomarkers. Thus, resulting in a study possibility, searching for new tools with diagnostic and therapeutic approaches to multiple oncological diseases, as miRNAs and sRNAs are main players of gene expression and host–infectious agent interaction. Moreover, sRNAs with limited complementarity are similar to eukaryotic miRNAs in their ability to modulate the activity and stability of multiple mRNAs. Here, we will describe the regulatory RNAs from viruses that have been associated with cancer and how sRNAs in bacteria can be related to this disease.

show abstract

Helicobacter pylori Outer Membrane Vesicles and Extracellular Vesicles from Helicobacter pylori-Infected Cells in Gastric Disease Development

Cited by 35 publications

References 186 publications

Immunological Perspective: Helicobacter pylori Infection and Gastritis

Immunological Perspective: Helicobacter pylori Infection and Gastritis

Extracellular vesicles from helicobacter pylori‐infected cells and helicobacter pylori outer membrane vesicles in atherosclerosis

MicroRNAs Encoded by Virus and Small RNAs Encoded by Bacteria Associated with Oncogenic Processes

Contact Info

Product

Resources

About