Helicobacter pylori Promotes Epithelial–Mesenchymal Transition in Gastric Cancer by Downregulating Programmed Cell Death Protein 4 (PDCD4)

Yu, Han; Zeng, Jiping; Liang, Xiao; Wang, Wenfu; Zhou, Yabin; Sun, Yuan; Liu, Shili; Li, Wenjuan; Chen, Chunyan; Jia, Jihui

doi:10.1371/journal.pone.0105306

Cited by 62 publications

(53 citation statements)

References 38 publications

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“…2a). Low PDCD4 level was associated with moderately/poorly differentiated head and neck cancers (OR 4.25, 95% CI 1.87–9.66) [20, 21] and digestive system cancers (OR 2.87, 95% CI 1.84–4.48) [15, 23, 25–27] (Fig. 3a).…”

Section: Resultsmentioning

confidence: 99%

The clinical association of programmed cell death protein 4 (PDCD4) with solid tumors and its prognostic significance: a meta-analysis

Gao

et al. 2016

Chin J Cancer

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BackgroundProgrammed cell death protein 4 (PDCD4) is a novel tumor suppressor protein involved in programmed cell death. Its association with cancer progression has been observed in multiple tumor models, but evidence supporting its association with solid tumors in humans remains controversial. This study aimed to determine the clinical significance and prognostic value of PDCD4 in solid tumors.MethodsA systematic literature review was performed to retrieve publications with available clinical information and survival data. The eligibility of the selected articles was based on the criteria of the Dutch Cochrane Centre proposed by the Meta-analysis Of Observational Studies in Epidemiology group. Pooled odds ratios (ORs), hazard ratios (HRs), and 95% confidence intervals (CIs) for survival analysis were calculated. Publication bias was examined by Begg’s and Egger’s tests.ResultsClinical data of 2227 cancer patients with solid tumors from 23 studies were evaluated. PDCD4 expression was significantly associated with the differentiation status of head and neck cancer (OR 4.25, 95% CI 1.87–9.66) and digestive system cancer (OR 2.87, 95% CI 1.84–4.48). Down-regulation of PDCD4 was significantly associated with short overall survival of patients with head and neck (HR: 3.44, 95% CI 2.38–4.98), breast (HR: 1.86, 95% CI 1.36–2.54), digestive system (HR: 2.12, 95% CI 1.75–2.56), and urinary system cancers (HR: 3.16, 95% CI 1.06–9.41).ConclusionsThe current evidence suggests that PDCD4 down-regulation is involved in the progression of several types of solid tumor and is a potential marker for solid tumor prognoses. Its clinical usefulness should be confirmed by large-scale prospective studies.

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Section: Resultsmentioning

confidence: 99%

The clinical association of programmed cell death protein 4 (PDCD4) with solid tumors and its prognostic significance: a meta-analysis

Gao

et al. 2016

Chin J Cancer

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“…H. pylori infection could decrease acid secretion by the production of ammonia and bicarbonate from urea. Additionally, these two products could serve as substrates for other bacteria and the gastric microbiota changed [35].…”

Section: Discussionmentioning

confidence: 99%

“…Cag+ strains contract with host cells and thereby activate multiple signaling pathways that may increase the risk for malignant transformation during prolonged colonization. H. pylori CagA induce TWIST1 expression and EMT in gastric cancer cells by regulating PDCD4 [35].…”

Section: Archives Of Clinical Microbiology Issn 1989-8436mentioning

confidence: 98%

Interaction of Helicobacter Pylori with Other Microbiota Species in the Development of Gastric Cancer

Liu¹,

Nie²,

Liang³

et al. 2017

Arch Clin Microbiol

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Gastric adenocarcinoma is the second-leading cause of cancer-related death in the world. Helicobacter pylori is a Gram-negative bacterial species that selectively colonizes gastric epithelium. The resulting chronic infection is the most significant risk factor for gastric adenocarcinoma identified so far. In the host, H. pylori interacts with microorganisms, which is likely involved in the development of gastric cancer. To identify H. pylori-associated bacteria and explore the contributions of these inter-bacterial events in the process of gastric cancer, we examined the interactions of H. pylori with other microbes in the microbiota community that are implicated in the development and progression of gastric cancer. A better understanding of the complex interactions between H. pylori and altered microbiota is critical to develop personalized therapies and approaches.

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“…Downregulation of the tumor suppressor protein PDCD4 (programmed cell death 4) [1] has been linked to diverse human cancers, including liver, [2a] colorectal, [2b] brain, [2c] ; ovarian, [2d] and gastric carcinomas. [2e] Conversely, murine epidermal cells resistant to tumor promotion possess elevated levels of PDCD4.…”

mentioning

confidence: 99%

“…[2e] Conversely, murine epidermal cells resistant to tumor promotion possess elevated levels of PDCD4. [;1a] Hence, PDCD4 has emerged as a target for the development of anticancer drugs.…”

mentioning

confidence: 99%

Total Synthesis of Cryptocaryol A by Enantioselective Iridium‐Catalyzed Alcohol C−H Allylation

2016

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Helicobacter pylori Promotes Epithelial–Mesenchymal Transition in Gastric Cancer by Downregulating Programmed Cell Death Protein 4 (PDCD4)

Cited by 62 publications

References 38 publications

The clinical association of programmed cell death protein 4 (PDCD4) with solid tumors and its prognostic significance: a meta-analysis

The clinical association of programmed cell death protein 4 (PDCD4) with solid tumors and its prognostic significance: a meta-analysis

Interaction of Helicobacter Pylori with Other Microbiota Species in the Development of Gastric Cancer

Total Synthesis of Cryptocaryol A by Enantioselective Iridium‐Catalyzed Alcohol C−H Allylation

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