Helicobacter pylori Standard Triple Therapy Outcomes in Iranian Population: A Retrospective Population-based Study in Mashhad, Northeast of Iran

Abstract

Background: Helicobacter pylori infection is one of the most prevalent infections in many areas of the world, which is treated with different combinations of medications. Objectives: This study aimed to investigate the response rate and outcomes of H. pylori-infected Iranian patients treated with triple therapy. Methods: The current study examined the records of patients with dyspepsia referred to Imam Reza hospital's gastroenterology clinic in Mashhad, Iran, diagnosed with H. pylori from 2017 to 2019. The patients received the triple therapy for H. pylori and were divided into responsive and non-responsive groups. Results: Out of the 750 patients, 477 were included in the study. The response rate to H. pylori standard triple therapy was 79% after 14 days of treatment. Patients aged 30 - 39 years had the highest rate of treatment response. There was no significant relationship between the response rate to treatment and smoking (P = 0.74), alcohol consumption (P = 0.91), opium addiction (P = 0.89), history of aspirin (P = 0.46) or nonsteroidal anti-inflammatory drugs (NSAIDs) use (P = 0.66), diabetes (P = 0.18), renal failure (P = 0.054), and family history of GI malignancies (P = 0.51). Furthermore, patients with gastric ulcer (P = 0.43), duodenal ulcer (P = 0.66), and gastric precancerous lesions (P = 0.93) showed no significant difference in response to treatment. Conclusions: The H. pylori triple therapy regimen can be an effective medication strategy for H. pylori infection in the Iranian population.

Prevalence, characteristics, and risk factors of non-alcoholic fatty liver disease in North East of Iran: a population-based study

“…Despite several studies have been reported various ranges of NAFLD prevalence in the Iranian general population from 7 to 45%, almost many studies unanimous that this metabolic disorder prevalence is increased approximately 40% in the past two decades [11,12]. This increase with a steep slope can be due to the people's lifestyle changes, as the NAFLD major knew risk factors are obesity, diabetes mellitus, dyslipidemia, and low HDL levels [13]; Moreover, some other conditions and disorders such as viral hepatitis, hypothyroidism, polycystic ovary syndrome, and smoking are under investigations as the possible risk factors of the NAFLD [13][14][15]. A focus on the Iranian adult general population indicated a wide range of the NAFLD prevalence in various regions of the country; however, there is a lack of information about many areas of the country due to a lack of accurate reports [16].…”