Helicobacter pylori stimulates pepsinogen secretion from isolated human peptic cells

Lorente, Sara; Doiz, O; Serrano, M.T.; Castillo, Jaime; Lanas, Ángel

doi:10.1136/gut.50.1.13

Cited by 59 publications

(47 citation statements)

References 26 publications

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“…32,33 We assume that the correlation between PG levels and histological atrophy is weakened by the combined effect of these three factors prior to eradication, whereas inflammation and H. pylori would have no ongoing effect after eradication, and thus the correlation between PG and atrophy would thereby be strengthened. In other words, prior to eradication, PG is released from chief cells in response to inflammation and H. pylori, or enters the blood in large amounts because of the destruction of chief cells.…”

Section: Discussionmentioning

confidence: 99%

Correlation of serum pepsinogen with histological atrophy following successful Helicobacter pylori eradication

Kawai

Kawakami

Kataoka

et al. 2006

Aliment Pharmacol Ther

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Section: Discussionmentioning

confidence: 99%

Correlation of serum pepsinogen with histological atrophy following successful Helicobacter pylori eradication

Kawai

Kawakami

Kataoka

et al. 2006

Aliment Pharmacol Ther

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“…In addition, gastric mucosal inflammation increases secretion of PGI and PGII from the chief cells, caused by cytokines, signal mediators, or H. pylori infection. [21][22][23] These could explain various cut-off values of serum PG profiles in different populations. For instance, in Japan, the proposed cut-off points to determine atrophy and gastric cancer risk are 70μg/L for PGI and 3.0 for PGI/II ratio.…”

Section: Discussionmentioning

confidence: 99%

Low Levels of Pepsinogen I and Pepsinogen I/II Ratio are Valuable Serologic Markers for Predicting Extensive Gastric Corpus Atrophy in Patients Undergoing Endoscopic Mucosectomy

et al. 2010

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Background/Aims: The levels of pepsinogen (PG) I and the PGI/II ratio are useful serologic markers for chronic atrophic gastritis. This study evaluated the performance and clinical implications of these markers in patients undergoing endoscopic mucosectomy. Methods: We enrolled 142 consecutive patients with early gastric tumors and Helicobacter pylori infection who were eligible for mucosectomy. Chronic gastritis and atrophy were assessed using four defined biopsy procedures. Serum PGs were measured by an enzyme immunoassay. Optimal diagnostic cut-offs and performance were determined using receiver operating characteristic curves. Results: The PGI level and the PGI/II ratio decreased with corpus-dominant gastritis and as atrophy advanced toward the corpus greater curvature (GC). For the presence of corpus GC atrophy, the areas under the PGI and PGI/II-ratio curves were 0.82 and 0.77, respectively. The optimal cut-off levels were 59.3μg/L for PGI (sensitivity, 83.3%; specificity, 78.4%) and 3.6μg/L for PGI/II ratio (sensitivity, 70.0%; specificity, 78.4%). Using these serologic cut-off levels, we found that the frequency of corpus tumor location differed significantly (32.9% vs 11.1% for PGI ＜59.3 and ≥59.3μg/L, respectively; and 31.1% vs 14.8% for PGI/II ratio ＜3.5 and ≥3.5, respectively; p＜0.05). Conclusions: A low PGI level and PGI/II ratio are valuable serologic markers for predicting corpus GC atrophy, and have clinical implications with respect to the corpus location of tumors in mucosectomy patients. (Gut Liver 2010;4:475-480)

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“…The presence of H. pylori, either addressed by serological evaluation or by immunohistochemistry in bioptic specimens, seems to increase pepsinogen I and II levels and decrease pepsinogen I/II ratio in conjunction with inflammation. [72][73][74] As suggested, no modifications in cut-off of pepsinogen test, or the inclusion of H. pylori serology, were reported or showed any improvements. Some authors 43,74 showed that the decrease of pepsinogen I/II ratio is independent of the presence of H. pylori.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis on the validity of pepsinogen test for gastric carcinoma, dysplasia or chronic atrophic gastritis screening

Dinis-Ribeiro

Yamaki

Miki³

et al. 2004

J Med Screen

186

154

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Aim:To assess the validity of the measurement of pepsinogen I and II as a screening test for gastric cancer and pre-malignant lesions, namely low-grade dysplasia, both in the general population and in selected groups of patients. Methods:A meta-analysis of sensitivity and specificity results from individual papers on the use of the pepsinogen test. An intrinsic cut-off effect was assumed and a random effect model was used for pooling.Results: Forty-two data sets were included: 27 (64%) population-based screening studies (n=296,553) and 15 (36%) sets of selected individuals (n=4385). Homogenous sensitivity and diagnostic odds ratio (DOR) estimates were found in studies using both pepsinogen I levels and pepsinogen I/II ratio calculations. Pooled pairs of sensitivity and false positive rates (FPr) for pepsinogen I ≤70; pepsinogen I/II ratio ≤3, pepsinogen I ≤50; pepsinogen I/II ratio ≤3, and pepsinogen I ≤30; pepsinogen I/II ratio ≤2, were sensitivity 77%/FPr 27%, sensitivity 68%/FPr 31%, and sensitivity 52%/FPr 84%, respectively. Positive predictive values (PPV) varied between 0.77% and 1.25%, and negative predictive values (NPV) varied between 99.08% and 99.90%. In selected groups, pooling was only possible when considering pepsinogen I ≤70; pepsinogen I/II ratio ≤3: giving sensitivity 57%, specificity 80%, PPV 15% and NPV 83%. As for the diagnosis of dysplasia, studies considering pepsinogen I <50; pepsinogen I/II ratio <3 obtained sensitivity 65% and specificity ranging from 74%-85%, both with NPV >95%. Conclusion:Pepsinogen test definition should include pepsinogen I/II ratio as consistency was obtained, both in population based studies and in selected groups for those studies that used pepsinogen I serum levels together with pepsinogen I/II ratio for screening for gastric cancer in highincidence regions other than Japan. Further studies of this test in the management of high-risk patients seem to be worthwhile.

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Helicobacter pylori stimulates pepsinogen secretion from isolated human peptic cells

Cited by 59 publications

References 26 publications

Correlation of serum pepsinogen with histological atrophy following successful Helicobacter pylori eradication

Correlation of serum pepsinogen with histological atrophy following successful Helicobacter pylori eradication

Low Levels of Pepsinogen I and Pepsinogen I/II Ratio are Valuable Serologic Markers for Predicting Extensive Gastric Corpus Atrophy in Patients Undergoing Endoscopic Mucosectomy

Meta-analysis on the validity of pepsinogen test for gastric carcinoma, dysplasia or chronic atrophic gastritis screening

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