Helicobacter pylori virulence dupA gene: risk factor or protective factor?

Silva, Lucas Luiz de Lima; Oliveira, Ana Karoline Silva; Gama, Aline Rodrigues; Ramos, Alfonso; Silva, Antônio Márcio Teodoro Cordeiro; Blanco, Angel José Vieira; Vieira, José Daniel Gonçalves; Rasmussem, L.T.; Carneiro, Lí­lian Carla; Barbosa, Mônica Santiago

doi:10.1007/s42770-021-00553-9

Cited by 7 publications

(5 citation statements)

References 41 publications

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“…Helicobacter pylori infections are considered to be the risk factor (carcinogen class I) for the development and progression of gastric cancer [ 94 – 96 ]. H. pylori secrets HtrA protease, which interacts with E-calmodulin and E-cadherin – members of cell adhesion molecules – and provides the possibility of bacterial invasion [ 96 , 97 ].…”

Section: Resultsmentioning

confidence: 99%

Exploring the Role of HtrA Family Genes in Cancer: A Systematic Review

Rosochowicz,

Kulcenty,

Suchorska

2024

Mol Diagn Ther

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Purpose HtrA1 , HtrA2 , HtrA3 and HtrA4 appear to be involved in the development of pathologies such as cancer. This systematic review reports the results of a literature search performed to compare the expression of HtrA family genes and proteins in cancer versus non-cancer tissues and cell lines, assess relationships between HtrA expression and cancer clinical features in cancer, and analyse the molecular mechanism, by which HtrA family affects cancer. Methods The literature search was conducted according to the PRISMA statement among four databases (PubMed, Web of Science, Embase and Scopus). Results A total of 38 articles met the inclusion criteria and involved the expression of HtrA family members and concerned the effect of HtrA expression on cancer and metastasis development or on the factor that influences it. Additionally, 31 reports were retrieved manually. Most articles highlighted that HtrA1 and HtrA3 exhibited tumour suppressor activity, while HtrA2 was associated with tumour growth and metastasis. There were too few studies to clearly define the role of the HtrA4 protease in tumours. Conclusion Although the expression of serine proteases of the HtrA family was dependent on tumour type, stage and the presence of metastases, most articles indicated that HtrA1 and HtrA3 expression in tumours was downregulated compared with healthy tissue or cell lines. The expression of HtrA2 was completely study dependent. The limited number of studies on HtrA4 expression made it impossible to draw conclusions about differences in expression between healthy and tumour tissue. The conclusions drawn from the study suggest that HtrA1 and HtrA3 act as tumour suppressors. Supplementary Information The online version contains supplementary material available at 10.1007/s40291-024-00712-2.

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Section: Resultsmentioning

confidence: 99%

Exploring the Role of HtrA Family Genes in Cancer: A Systematic Review

Rosochowicz,

Kulcenty,

Suchorska

2024

Mol Diagn Ther

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“…In a study by Silva et al, (2021), they found that infection with dupA-positive H. pylori increases the risk of developing chronic gastritis in women (17).…”

Section: Discussionmentioning

confidence: 99%

Immunological Study of Gastroduodenal Disorders Patients Infected with H. Pylori in Basrah Province-Iraq

Hilfi¹,

Alsaimary²,

Hilfi³

2022

PJMHS

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The purpose of the current study was to investigate the immunological finding of the most important Helicobacter pylori virulence factors CagA, VacA, DupA, HopQ, and IceA genotypes in gastric biopsies of gastroduodenal diseases patients infected with H. pylori, and to determine the concentrations of CagA, VacA, DupA, HopQ, and IceA in the sera of the patients infected with H. pylori in Iraq-Basrah, by using ELISA technique, to give acknowledge about the role of these virulence factors in patients with the gastroduodenal disorder. A case-control study included 112 confirmed gastroduodenal patients and 112 healthy individuals as a control group. Data about age, gender, smoking, alcohol abuse, family history, occupation, residence, and clinical findings for all study populations were collected. Blood samples have been gathered from each patient as well as the control group. Each individual in this study was examined under the supervision of a gastroenterologist and was subjected to a urea breath test (UBT) for definitive confirmation of H. pylori infection. The finding of this study show a significant effect of these factors with an increased risk of gastroduodenal disorder. Conclusion: The study show a significant effect of the studied virulence factors (CagA, VacA, DupA, HopQ, and IceA) with an increased risk of gastroduodenal disorder of Iraqi population in Basrah province. Keywords: Immunological factors, gastroduodenal disorder, Helicobacter pylori, ELISA, CagA, VacA, DupA, HopQ, and IceA.

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“…The other two samples were transported under refrigeration and stored at -20˚C at the Núcleo de Estudos da Helicobacter pylori (NEHP), located at the Federal University of Goiás. These samples were subjected to molecular analysis, in accordance with previous studies published by NEHP (19,20) .…”

Section: Population and Samplesmentioning

confidence: 99%

Helicobacter Pylori Oipa Virulence Gene as a Molecular Marker of Severe Gastropathies

MACIEL,

SILVA,

ASSUNÇÃO

et al. 2024

Arq. Gastroenterol.

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Background: Helicobacter pylori is an etiologic agent of gastroduodenal diseases. The microorganism, considered a type I carcinogen, affects about 50% of the global population. H. pylori virulence factors are determinant for the clinical outcome of the infection. The outer inflammatory protein A (oipA) gene encodes an outer membrane adhesin and is related to severe gastropathies, such as gastric cancer. Objective: The aim of this study was to evaluate the association of the oipA gene with the severity of gastroduodenal diseases in dyspeptic patients in region Central Brazil. Methods: The polymerase chain reaction (PCR) was used to determine the presence of H. pylori. Samples positives were used for molecular screening of the oipA gene. Gastropathies were categorized as non-severe and severe diseases. Results: Approximately 68% of patients had H. pylori and 36% were infected with H. pylori oipA+ strains. Infection was significantly associated in patients aged over 44 years (P=0.004). However, there was no association between oipA and patients’ age (P=0.89). Approximately 46% of patients infected with oipA+ strains had some severe illness. Gastric adenocarcinoma was the most frequent severe gastropathy. The H. pylori oipA genotype was inversely associated with the severity of gastroduodenal diseases (OR=0.247, 95%CI: 0.0804-0.7149 and P=0.007). Conclusion: The characterization of possible molecular markers will contribute to personalized medicine, impacting the prognosis of patients.

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Helicobacter pylori virulence dupA gene: risk factor or protective factor?

Cited by 7 publications

References 41 publications

Exploring the Role of HtrA Family Genes in Cancer: A Systematic Review

Exploring the Role of HtrA Family Genes in Cancer: A Systematic Review

Immunological Study of Gastroduodenal Disorders Patients Infected with H. Pylori in Basrah Province-Iraq

Helicobacter Pylori Oipa Virulence Gene as a Molecular Marker of Severe Gastropathies

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