The Amsterdam‐St. Paul (ASP) Plateau formed by interaction between the South East Indian Ridge (SEIR) and the ASP mantle plume during the last 10 Myr. The combined bathymetry and gravity‐derived crustal thickness anomalies along the present and paleoaxes of the SEIR atop the plateau indicate: (1) a thicker crust and shallower water depth along the southern part of segment I2 during much of the last 10 Myr; (2) an earlier decrease (~1.4 Ma) in crustal thickness along the southern part of I2 compared to the northern part (~0.9 Ma) during the most recent period of reduced magmatism; (3) a topographic transition at ~0.7 Ma and during the last 0.1 Myr; and (4) an approximately uniform crustal thickness (8 km) along the entire I2 segment today. These observations require spatial and temporal variations in magma production during construction of the ASP Plateau over the last 3 Myr. We propose that during periods of weaker plume magma flux, spatial variations in upper mantle temperature and composition are small, and lead to small variations in crustal thickness along‐axis. In contrast, during periods of stronger plume magma flux, spatial contrasts in upper mantle temperature and composition (fertility) are large, leading to significant variations in crustal thickness. Along‐axis variations of 3He/4He, Δ8/4Pb, K/Ti, and Na8 in “zero‐age” basalts indicate that there is a gradient in the underlying mantle material, from a “common” mantle plume component (Δ8/4Pb~60) stronger in the north to a DUPAL component (Δ8/4Pb~110) dominating in the south.