Helix to coil transition in poly-l-amino acids

Bradbury, J. H.; Fenn, M. David

doi:10.1016/0022-2836(68)90378-1

Cited by 37 publications

(5 citation statements)

References 30 publications

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“…31 The 1 H chemical shift of the R-proton of the polypeptide backbone is diagnostic of secondary structure in R-helical homopolypeptides. 32 In deuterated chlorobenzene, this chemical shift was not easily observed due to it lying coincident to that of the protons R to the triazole. The amide proton is known to be less diagnostic than the peptide R-proton of changes in secondary conformation of amides.…”

Section: ' Optoelectronic Characterization Of 1à3mentioning

confidence: 96%

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Hierarchical Self-Assembly of Semiconductor Functionalized Peptide α-Helices and Optoelectronic Properties

et al. 2011

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To determine the ability of semiconductors templated by α-helical polypeptides to form higher order structures and the charge carrier properties of the supramolecular assemblies, L-lysine was functionalized with a sexithiophene organic semiconductor unit via iterative Suzuki coupling and the click reaction. The resultant amino acid was incorporated into a homopolypeptide by ring-opening polymerization of an amino acid N-carboxyanhydride. Spectroscopic investigation of the polypeptide revealed that it adopted an α-helical secondary structure in organic solvents that underwent hierarchical self-assembly to form higher order structures. In cyclohexane, the polymer formed organogels at 2% (w/v). Organic photovoltaic and organic field effect transistor devices were fabricated by deposition of the PCBM blended active layer from chlorobenzene at concentrations shown to induce self-assembly of the polymer. Compared with control compounds, these devices showed significantly greater hole mobility, short circuit current, and efficiency. This work establishes the potential of this previously unreported bioinspired motif to increase device performance.

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Section: ' Optoelectronic Characterization Of 1à3mentioning

confidence: 96%

“…The 1 H chemical shift of the α-proton of the polypeptide backbone is diagnostic of secondary structure in α-helical homopolypeptides . In deuterated chlorobenzene, this chemical shift was not easily observed due to it lying coincident to that of the protons α to the triazole.…”

Section: Self-assemblymentioning

confidence: 99%

Hierarchical Self-Assembly of Semiconductor Functionalized Peptide α-Helices and Optoelectronic Properties

et al. 2011

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“…The resulting polymer was fractionally precipitated by adding ethanol and lyophilized from dioxane. The molecular weight of the PBLG sample used was estimated to be 2.1 x l0 s from its intrinsic viscosity in DMF at 25 °C, using the graph given by Bradbury and Fenn (7).…”

Section: Methodsmentioning

confidence: 99%

The effect of dichloroacetic acid on the electric and hydrodynamic properties of poly-γ-benzyl-L-glutamate in solution

Ohe

Yoshioka

1974

Colloid Polymer Sci

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“…With sodium, potassium, and ammonium ions the protons are replaced by the cations in two stages. [3][4][5][6] The first exchange reaction leads to the formation of the half-exchanged phase. This is followed by conversion of the half-exchanged phase to a phase containing 2 mol of cation per formula weight.…”

Section: Publication Costs Assisted By the Ohio University Research I...mentioning

confidence: 99%

Pseudopolyelectrolyte polyamino acids

Lotan¹

1973

J. Phys. Chem.

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The conformational changes of poly-jV5-(4-hydroxybutyl)-L-glutamme have been investigated in the LiCl-methanol solvent system. Optical rotatory dispersion (ORD) measurements indicate that, with increasing LiCl concentration, an -helix-to-random coil transition takes place, its midpoint being at about 3 M LiCl. Intrinsic viscosity measurements, on the other hand, reveal two transitions. The first, in the range 2-4 M salt, is associated with a decrease in viscosity, as expected for the rod-like to disordered chain transformation suggested by the ORD data. The second, in the range 4-6 M salt, is characterized by an increase of viscosity, i.e., a change in the opposite direction. It is proposed that the polypeptide binds Li+ ions, thus acquiring polyelectrolyte character.

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Helix to coil transition in poly-l-amino acids

Cited by 37 publications

References 30 publications

Hierarchical Self-Assembly of Semiconductor Functionalized Peptide α-Helices and Optoelectronic Properties

Hierarchical Self-Assembly of Semiconductor Functionalized Peptide α-Helices and Optoelectronic Properties

The effect of dichloroacetic acid on the electric and hydrodynamic properties of poly-γ-benzyl-L-glutamate in solution

Pseudopolyelectrolyte polyamino acids

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