Introduction: Hem-o-lok ligation clips are widely used for the hemostatic control of major mesenteric vessels during laparoscopic colorectal resection. We report 2 rare cases of bowel obstruction and perforation requiring urgent surgical intervention after the application of Hem-o-lok clips (Weck Surgical Instruments, Teleflex Medical, Durham, NC, USA), which were used to occlude vessels and provide hemostasis during elective laparoscopic sigmoid colon resection. In both cases, the clips completely dislodged from the vessels to which they were initially applied and eventually attached to the wall of the small bowel, causing obstruction, ischemia, and perforation.