Hemangioma treatment with pulsed dye laser—distinct parameters used between neonatal and non-neonatal patients

Abstract

PDL, with distinct parameters, was effective in the treatment of IHs in neonates. After each laser treatment, neonates recovered faster than non-neonatal patients.

Noteworthy effects of a long-pulse Alexandrite laser for treatment of high-risk infantile hemangioma: A case report and literature review

“…The efficacy and safety of laser treatment in dermatology was completely improved in 1983 due to the introduction of the selective photothermolysis theory by Anderson and Parrish[36]. Numerous studies have confirmed the efficacy of PDL treatment, especially for the treatment of superficial IHs[37,38]. However, it was not very effective for thick/deep IHs, because of the limited penetration of the laser.…”

Efficacy Evaluation of 755-nm Long-Pulse Alexandrite Laser Combined with 0.5% Timolol Maleate Eye Drops in the Treatment of Thicker Infantile Hemangioma

“…(1) IH that meets the relevant diagnostic criteria in the Guidelines for the Diagnosis and Treatment of Hemangiomas and Vascular Malformations in 2019; 22 (2) B-ultrasound manifested the thickness of the IH is greater than 2mm and less than or equal to 8mm; (3) The child has not received other treatments before diagnosis and treatment; (4) Children with multiple lesions were excluded. (5) Children with skin lesions on the scalp, eyelids and perineum were excluded. A total of 78 children with IH were collected, including 21 males (26.9%) and 57 females (73.1%), with an age of (4.5 ± 1.4) months (range 22 days to about 6 months).…”

“…At present, laser treatment of superficial IH is mainly based on pulsed dye laser (PDL) (wavelength 585 nm or 595 nm) and the non-selective β-blocker timolol. [4][5][6] According to the existing literature, IH > 2 mm is regarded as thicker IH. [7][8][9] However, PDL has insufficient penetration depth for thicker IH, so the treatment result is not ideal.…”

Infantile Hemangiomas: An Update on Pathogenesis and Treatment

“…Laser treatment is not recommended during the proliferative phase of IH growth [20,64,65] due to a lack of effectiveness and the risk of potential complications [66]. However, Zhang et al showed that the use of PDL in neonates requires less energy and reduces recovery time between sessions compared to non-neonates [67]. Laser treatment plays a significant role in treating residual lesions, such as telangiectasia [64].…”