Hemangiomas of Infancy

Chiller, Katarina G.; Passaro, Douglas J.; Frieden, Ilona J.

doi:10.1001/archderm.138.12.1567

Cited by 357 publications

(72 citation statements)

References 25 publications

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“…They thus concluded that these two groups of facial hemangiomas follow different patterns of involvement, behave differently and may well respond differently to treatment. These results were confirmed by Chiller et al [1]. In comparison to the study of Warner et al [2], we detected somewhat more superficial forms, and the superficial form was especially represented in the male population (53%).…”

Section: Discussionsupporting

confidence: 91%

“…Its now widely accepted that childhood hemangiomas of infancy can be divided in two different types: nodular hemangiomas and superficial ‘plake-like’ hemangiomas [1,2,3]. Superficial lesions have a higher frequency of complications including spreading ulceration and associated malformations [2, 3].…”

Section: Discussionmentioning

confidence: 99%

“…Infantile hemangiomas are the most common benign tumors of infancy, affecting 2% of all newborns and as many as 10% of infants by 1 year of age in a white population [1] with a female/male ratio of 3/1. Hemangiomas can be subdivided into superficial, deep or compound forms; or as focal and nodular on the one hand and superficial or ‘plake-like’ on the other hand [1,2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Hemangiomas can be subdivided into superficial, deep or compound forms; or as focal and nodular on the one hand and superficial or ‘plake-like’ on the other hand [1,2,3]. Nodular hemangiomas are elevated, have well-defined borders and usually affect one anatomical site.…”

Section: Introductionmentioning

confidence: 99%

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SACRAL Syndrome: Spinal Dysraphism, Anogenital, Cutaneous, Renal and Urologic Anomalies, Associated with an Angioma of Lumbosacral Localization

et al. 2006

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Background: Publications concerning perineal infantile hemangiomas are scarce, and comprise no large series. Objective: Studying clinical features of hemangiomas of the perineal area, complications and associated malformations. Methods: Retrospective analysis of all hemangiomas localized in the perineal area, encountered at the Children’s Hospital in Bordeaux from 1994. Results: Of 49 perineal hemangiomas (34 girls, 15 boys), 5 patients had accompanying malformation, mainly lipomyelomeningocele with tethered cord. The superficial hemangiomas were more represented in males and presented sooner than the nodular counterpart. The average rate of ulceration was 73%, ulcerations developed earlier in the superficial forms than their nodular counterparts (2 vs. 4 months). Conclusion: Superficial perineal hemangiomas are more often complicated by ulceration, and are associated with developmental anomalies. As a counterpart for the PHACE syndrome in facial hemangioma, we propose the acronym SACRAL for perineal hemangiomas: Spinal dysraphism, Anogenital anomalies, Cutaneous anomalies, Renal and urologic anomalies, associated with Angioma of Lumbosacral localization.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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SACRAL Syndrome: Spinal Dysraphism, Anogenital, Cutaneous, Renal and Urologic Anomalies, Associated with an Angioma of Lumbosacral Localization

et al. 2006

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“…As a general rule, these lesions tend to show spontaneous regression during childhood. Segmental hemangioma of infancy, however, shows a high frequency of complications [2,3]. This particular form of hemangioma has a prolonged growth phase [4] and tends to involute more slowly [2].…”

Section: Introductionmentioning

confidence: 99%

Superimposed Segmental Hemangioma of Infancy

Happle¹

2009

Dermatology

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Background: Segmental hemangioma of infancy is sometimes associated with the development of multiple nonsegmental hemangiomas. Such co-occurrences have so far remained unexplained. Methods and Results: Pertinent reports were collected from the literature. To explicate such cases, the following concept is proposed. Hemangiomas of infancy reflect a polygenic predisposition. Nonsegmental lesions result from a mutational event occurring at a late stage of intrauterine life or after birth, whereas segmental hemangioma originates from loss of heterozygosity or some other mutational event arising at an early developmental stage. Conclusion: In this way, segmental hemangioma of infancy could be taken as a further example of the superimposed segmental manifestation of a polygenic skin disorder. Future molecular research may show whether this assumption holds true.

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