Hematocrit and mean arterial blood pressure in pre- and postmenopause women

Vázquez, Beatriz Y. Salazar; Vázquez, Miguel A. Rodríguez; Intaglietta, Marcos; Fairé, Ulf dé; Fagrell, B; Cabrales, Pedro

doi:10.2147/vhrm.s5798

Cited by 6 publications

(6 citation statements)

References 12 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a study of 128 normotensive members of a large employed population in New York City (51 ± 10 years) there was a significant independent relation between MAP and blood viscosity, 9 and a study of 628 individuals in the population of Victoria de Durango with men and women pooled data showed a weak positive correlation between MAP and Hct. 10 Our findings and some 11 , 12 but not all results in the literature 13 , 14 support the contention that Hct and blood viscosity are not a factor in regulating blood pressure in the healthy normal population within limits that include the systematic elevation of Hct due to adaptation to moderate altitude.…”

Section: Discussionsupporting

confidence: 75%

“…The results of this study, those from experimental studies 16 and results in children 12 and premenopausal women 11 indicate that blood pressure is not correlated with blood viscosity. Therefore a population presenting a positive correlation between blood pressure and blood viscosity (or Hct) is probably affected by endothelial dysfunction and/or pathologies that reduce or abolish the endothelial response to shear stress.…”

Section: Discussionmentioning

confidence: 43%

See 1 more Smart Citation

Blood pressure and blood viscosity are not correlated in normal healthy subjects

Vázquez¹

2011

VHRM

View full text Add to dashboard Cite

The relationship between blood viscosity, hematocrit (Hct), and mean arterial blood pressure (MAP) was studied in a healthy population of 91 men and 66 women with an average age of 30.6 ± 8.0 years, from the city of Victoria de Durango (1800 m elevation). In women and men, Hct values were 42.4% ± 2.9% and 47.2% ± 2.3%, blood viscosities were 4.5 ± 0.7 and 6.1 ± 1.0 cP, and MAP was 83.0 ± 6.8 and 88.0 ± 6.1 mmHg, respectively. The correlation between blood viscosity and Hct was linear and positive (r2 = 0.48) and identical to that of previous studies reported in the literature when men and women are taken as a single group. Separating the data by gender yielded positive, linear correlations (r2 = 0.18 and 0.10, respectively) with identical slopes, however blood viscosity for men was 1.2 cP greater than in women (P = 0.02). MAP and blood viscosity (and Hct) were not statistically associated when men and women were analyzed separately and were weakly positively correlated (r2 = 0.08, P < 0.02) when treated as a group. The present results suggest that studies that show a positive correlation between MAP and blood viscosity (and Hct) do not differentiate data according to gender, or involve populations that do not compensate for increased blood viscosity and potentially increased shear stress.

show abstract

Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 43%

Blood pressure and blood viscosity are not correlated in normal healthy subjects

Vázquez¹

2011

VHRM

View full text Add to dashboard Cite

show abstract

“…The effect of aging on endothelial function is evident in women that pass from pre- to postmenopause. 31 Salazar Vázquez et al 32 analyzed the distribution of MAP and Hct in a population of pre- and postmenopause women from the city of Durango, Mexico. In this study, healthy nonsmoking premenopausal women ( n =85) showed a nonsignificant negative correlation ( P =0.5) between MAP and Hct, while menopausal women ( n =92) presented a positive correlation ( P <0.01).…”

Section: Discussionmentioning

confidence: 99%

“…Women aged >60 years in the city of Stockholm, Sweden, ( n =2,189) showed an identical MAP/Hct trend to that of menopausal women in Durango. 32 …”

Section: Discussionmentioning

confidence: 99%

Influence of serological factors and BMI on the blood pressure/hematocrit association in healthy young men and women

Vázquez

Chávez-Negrete

et al. 2014

VHRM

Self Cite

View full text Add to dashboard Cite

The association between mean arterial blood pressure (MAP) and hematocrit (Hct) as a surrogate for blood viscosity was investigated in a young (average 20.0±2.3 years), healthy population of 174 men and 442 women. Health status was assessed by clinical examination and serological evaluation. Individuals with severe anemia or hemoconcentration, prior traumas or major surgical intervention, smokers, and pregnant or lactating women were excluded from the study. The MAP/Hct association was positive and significant (P=0.04) for women and negative, albeit not significantly so, for men. The MAP/Hct association was also evaluated in subgroups of the same population with a progressive step-by-step exclusion of: individuals with cholesterol >200 mg/dL; triglycerides >200 mg/dL; body mass index >25 kg/m2; and glucose >100 mg/dL. This consecutively reduced the strength of the positive MAP/Hct association in women, which became negative – although not significantly so – when all anomalously high factors were excluded. The same trend was found in men. Our study indicates that previously reported positive trends in the relationship between the MAP and Hct in the population are not present in a young, healthy population of men or women that excludes individuals with the confounding factors of above normal serological values and BMI.

show abstract

“…[17][18][19] Several studies report the association of conditions such as mean arterial blood pressure increase and osteoporosis with increased hematocrit in the postmenopausal period and therefore an increase in blood viscosity. 20,21 However, no studies have investigated the relationship between WBV or plasma viscosity and selected postmenopausal symptoms using the MRS. Demonstrating the existence of such a relationship may help in improving the quality of life of women in the postmenopausal period.…”

mentioning

confidence: 99%

Evaluation of the relationship between plasma viscosity and selected menopausal symptoms using the Menopause Rating Scale

et al. 2022

View full text Add to dashboard Cite

Objective: The aim of this study was to investigate whether whole blood viscosity and plasma viscosity are associated with the severity of postmenopausal symptoms using the Menopause Rating Scale (MRS).Methods: This study included 108 postmenopausal women admitted to menopause clinics. Participants were divided into two groups according to their MRS scores. Groups 1 (n = 52) and 2 (n = 56) were composed of healthy postmenopausal women with MRS scores of <14 and ≥14 points, respectively. The clinical findings and hemorheological parameters were compared between the two groups.Results: Comparing plasma viscosity levels between the two groups showed that group 1 had 1.25 ± 0.08 centipoise, whereas group 2 had 1.30 ± 0.10 centipoise ( P = 0.03). The difference in plasma viscosity between the two groups persisted after adjustment for age (1.24 ± 0.08 vs 1.31 ± 0.10; P < 0.001). Plasma viscosity was also significantly correlated with age (r = 0.384, P < 0.001), menopausal duration (r = 0.362, P < 0.001), and urogenital symptoms (r = 410, P < 0.001).Conclusions: Increased plasma viscosity levels were significantly associated with selected postmenopausal symptoms, independent of age.

show abstract

Hematocrit and mean arterial blood pressure in pre- and postmenopause women

Cited by 6 publications

References 12 publications

Blood pressure and blood viscosity are not correlated in normal healthy subjects

Blood pressure and blood viscosity are not correlated in normal healthy subjects

Influence of serological factors and BMI on the blood pressure/hematocrit association in healthy young men and women

Evaluation of the relationship between plasma viscosity and selected menopausal symptoms using the Menopause Rating Scale

Contact Info

Product

Resources

About