1999
DOI: 10.1007/s005200050221
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Hematogenous trichosporonosis in cancer patients: report of 12 cases including 5 during prophylaxis with itraconazol

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Cited by 96 publications
(66 citation statements)
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“…A similar situation has been termed "breakthrough" fungal infections in human medicine, and it is being reported more commonly in immunocompromised individuals (14,20,30). Other conspecifics receiving the same dose of itraconazole were later determined to exhibit itraconazole concentrations in plasma of about 2 to 3 g/ml, and kidney and lung tissue values were 8.6 and 4.7 times the plasma concentrations, respectively (C. A. Manire, H. L. Rhinehart, G. J. Pennick, D. Sutton, and M. G. Rinaldi, submitted for publication).…”
mentioning
confidence: 92%
“…A similar situation has been termed "breakthrough" fungal infections in human medicine, and it is being reported more commonly in immunocompromised individuals (14,20,30). Other conspecifics receiving the same dose of itraconazole were later determined to exhibit itraconazole concentrations in plasma of about 2 to 3 g/ml, and kidney and lung tissue values were 8.6 and 4.7 times the plasma concentrations, respectively (C. A. Manire, H. L. Rhinehart, G. J. Pennick, D. Sutton, and M. G. Rinaldi, submitted for publication).…”
mentioning
confidence: 92%
“…Although trichosporonemia represents a small percentage of all fungal invasive infections, Trichosporon spp. have been reported as the second-or third-most-common agents of yeast fungemia (13,21,51).Phenotypic methods for Trichosporon species identification usually generate inconsistent results, and none of the commercial tests available include the whole new taxonomic categories in their databases (1, 36, 37). For instance, it has been mentioned in the literature that an isolate identified by molecular methods as Trichosporon dermatis was mistakenly identified as Trichosporon mucoides when Vitek Systems 1 and 2 (BioMérieux, France) were used (16).…”
mentioning
confidence: 99%
“…Although trichosporonemia represents a small percentage of all fungal invasive infections, Trichosporon spp. have been reported as the second-or third-most-common agents of yeast fungemia (13,21,51).…”
mentioning
confidence: 99%
“…Disseminated Trichosporon infections are potentially lifethreatening and are often fatal in neutropenic patients (7,22). Although uncommon, pathogenic species of this genus have been reported increasingly, mostly in patients with malignant diseases (3,6,9,10,11,20,32,44,47,48,63,77), neonates (18,56,84), a bone marrow transplant recipient (22), a solid organ transplant recipient (50), and patients with human immunodeficiency virus (34,35,46). Trichosporon has also been reported to cause fungemia (5,9,25,29,30,33,53,62).…”
mentioning
confidence: 99%