Hematologic Characteristics of Patients with Active Pulmonary, Extra-Pulmonary and Disseminated Tuberculosis: A Study of  over Six Hundred Patients

Alamlih, Laith; Albakri, Mutaz; Ibrahim, Wanis H; Khan, Aziz; Khan, Fahmi Yousef

doi:10.4236/jtr.2020.82004

Cited by 5 publications

(4 citation statements)

References 15 publications

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“…Alamlih et al in a study conducted in Qatar reported a male predominance at 80.2%. 11 Similarly, Batool et al in Pakistan reported a male overrepresentation of 71.6% among the 500 PTB cases studied. 12 In India, Shah et al reported a proportion of males at 64% among studied subjects.…”

Section: Discussionmentioning

confidence: 85%

“…However, the exact mechanisms through which PTB causes suppressed RBC counts and anemia remains to be elucidated in future studies, so as to inform targeted therapeutic Nevertheless, the high prevalence of anemia recorded among newly diagnosed PTB patients in this study and several other studies warrant screening, management and routine monitoring of anemia as part of standard care for PTB in western Kenya. 9,[11][12][13][14][15] This is because anemia is considered major risk factor for TB-related severity and mortality. 28 Rohini et al showed that thrombocytopenia is the predominant platelet anomaly among PTB patients in India.…”

Section: Discussionmentioning

confidence: 99%

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Hematological profiles of newly diagnosed pulmonary tuberculosis patients in Western Kenya

Mwilitsa,

Kimoloi,

Raballah

2024

Int J Community Med Public Health

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Background: Pulmonary tuberculosis (PTB) mortality remains high despite current availability of effective anti-TB drugs. This could be due to pathophysiological derangements that are not fully understood and managed during anti-TB therapy. The objective of this study was to evaluate the hematological changes in newly diagnosed PTB patients. Methods: The 55 newly diagnosed PTB patients and 55 healthy controls were included in this cross-sectional non-randomized study. Complete hematological profiles were determined using an automatic analyzer. Peripheral blood films were used to evaluate cellular morphology. Data was analyzed using chi-square and Mann-Whitney tests (SPSS version 29.0). Results: Males constituted 80% (44) of the newly diagnosed PTB patients and 81.8% of the blood donor controls. Compared with the control group, the PTB patients group exhibited significantly lower median red blood cell (RBC) count (4.79×106 µL vs 5.2×106 µL, p=0.001), hemoglobin levels (12.8 g/dL vs 14.3 g/dL, p=0.0001), hematocrit (37.9% vs 42.05%, p=0.0001), mean platelet volume (8.9 fL vs 10.5 fL, p=0.0001) and platelet distribution width (10.4 fL vs 13.0 fL, p=0.0001). The median platelet count for the PTB group was significantly higher relative to controls (314.0×103/µL vs 237.0×103/µL, p=0.0001). Similarly, the PTB group had a significantly higher PCT% compared to controls (0.27% vs 0.25%, p=0.002). Morphological analysis of peripheral blood films revealed normocytic normochromic anemia and microcytic hypochromic anemia in 54.5% (n=30) and 34.6% (n=19) of PTB patients, respectively. Conclusions: Newly diagnosed PTB patients in Western Kenya present with leukocytosis, elevated platelet count and anemia, suggesting the need for appropriate management and routine monitoring of hematological profiles.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Hematological profiles of newly diagnosed pulmonary tuberculosis patients in Western Kenya

Mwilitsa,

Kimoloi,

Raballah

2024

Int J Community Med Public Health

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“…Tuberculosis cases often became either leukopenia or leukocytosis [ 36 ] with neutrophilia [ 36 , 37 ] and thrombocytosis being most common [ 38 , 39 ]. High prevalence of anemia among TB patients and high rate of TB among people with different forms of anemia have been reported by different studies [ 40 – 42 ]. However, whether anemia is a predisposing factor for TB or the vice versa remains an open question [ 41 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative serum lipid and immunohematological values among adult pulmonary tuberculosis and tuberculosis lymphadenitis cases and their association with sputum bacilli load and time to culture positivity in Northwestern Ethiopia

Mekonnen¹,

Nibret²,

Munshea³

et al. 2023

Lipids Health Dis

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Background The serum lipid and immunohematological values of tuberculosis lymphadenitis (TBLN) patients is poorly documented relative to pulmonary tuberculosis (PTB) cases. Therefore, the aim of this study was to investigate the serum lipid and immunohematological values of patients with TBLN in comparison with PTB (PTB) patients. Methods An institution-based comparative cross-sectional study was conducted in Northwest Ethiopia from March to December 2021. The study participants were bacteriologically confirmed PTB (n = 82) and TBLN (n = 94) cases with no known comorbidity and whose ages was greater than 18 years and with no current pregnancy. Independent sample t-test, one-way ANOVA, box plot, and correlation matrix were used to analyze the data. Results The body mass index (BMI), CD4 + T cell count, and high-density lipoprotein-Cholesterol (HDL-C) values were significantly higher among TBLN cases compared with PTB cases. Additionally, the total white blood cell (WBC) count, hemoglobin (Hb), total Cholesterol (CHO) and creatinine (Cr) values were relatively higher among TBLN than PTB (P > 0.05). On the reverse, the platelet count and triacylglycerol (TAG) values were relatively higher among PTB than in TBLN cases. While the mean days of culture positivity were 11.6 days for TBLN, the mean days of culture positivity were 14.0 days for PTB. Anemia and serum lipid values showed no correlation with sputum bacilli load and time to culture positivity. Conclusion Tuberculous lymphadenitis patients were well-endowed with serum lipid, immunological and nutritional status compared with PTB cases. Hence, the high incidence rate of TBLN in Ethiopia could not be explained by low peripheral immunohematological values, malnutrition, Anemia, and dyslipidemia. Further study for identifying the predictors for TBLN in Ethiopia is highly desirable.

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“…Meskipun saat ini telah ditemukan teknologi deteksi secara molekuler, namun penegakan diagnosis TB masih menghadapi beragam tantangan yang cukup sulit. Tantangan ini diantaranya berasal dari sifat paucibacilary alami dari M. tuberkulosis, lamanya waktu yang dibutuhkan untuk mendapatkan hasil kultur bakteri, masih rendahnya sensitivitas teknologi diagnosis yang baru serta manifestasi klinis yang beragam dari penyakit ini (Alamlih et al, 2020). Oleh karena itu, saat ini masih sangat dibutuhkan suatu penanda lain yang dapat mendukung penegakan diagnosis TB, selain menggunakan penanda yang sudah ada.…”

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Evaluasi Parameter Hematologi Pada Pasien Tuberkulosis Paru Di Kota Bandar Lampung

Yuniza¹,

Nuraini²,

Jaya³

2022

J.Medkes

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Penegakan diagnosis dini yang tepat menjadi faktor kunci pengendalian infeksi tuberkulosis paru (TB). Penelitian ini bertujuan untuk mengevaluasi parameter hematologi pada penderita tuberculosis di kota Bandar Lampung, guna mendapatkan parameter spesifik yang dapat digunakan sebagai penunjang diagnosa awal tuberculosis. Sebanyak 36 pasien yang telah terdiagnosa menderita TB berdasarkan pemeriksaan tes cepat molekuler dan apusan sputum, dibandingkan hasil pemeriksaan hematologinya dengan 28 orang sukarelawan sehat yang sesuai usia dan jenis kelaminnya. Parameter pemeriksaan darah rutin yang diperiksa berupa kadar Hb, Ht, indeks eritrosit, jumlah eritrosit, leukosit, trombosit dan nilai LED. Hasil penelitian menunjukan penderita TB memiliki rerata kadar Hb, Ht dan indeks eritrosit yang lebih rendah secara signifikan bila dibandingkan dengan kontrol normal (p<0,05). Penderita TB juga memiliki rerata jumlah leukosit, trombosit dan LED yang lebih tinggi secara signifikan dibandingkan dengan kelompok normal (p<0,05). Simpulan: Parameter pemeriksaan hematologi rutin berpotensi digunakan sebagai penanda awal adanya infeksi TB.

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Hematologic Characteristics of Patients with Active Pulmonary, Extra-Pulmonary and Disseminated Tuberculosis: A Study of over Six Hundred Patients

Cited by 5 publications

References 15 publications

Hematological profiles of newly diagnosed pulmonary tuberculosis patients in Western Kenya

Hematological profiles of newly diagnosed pulmonary tuberculosis patients in Western Kenya

Comparative serum lipid and immunohematological values among adult pulmonary tuberculosis and tuberculosis lymphadenitis cases and their association with sputum bacilli load and time to culture positivity in Northwestern Ethiopia

Evaluasi Parameter Hematologi Pada Pasien Tuberkulosis Paru Di Kota Bandar Lampung

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