Hematologic, iron-related, and acute-phase protein responses to sustained strenuous exercise

Taylor, C. B.; Rogers, G. G.; Goodman, Craig A.; Baynes, Roy D.; Bothwell, T. H.; Wr, Bezwoda; Kramer, F. Matthew; Hattingh, J.

doi:10.1152/jappl.1987.62.2.464

Cited by 107 publications

(61 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although elevated resting levels of CRP were shown in this study and have been shown elsewhere, 14,27 more studies seem to be revealing that athletes exhibit a chronic training/exercise-induced reduction in resting CRP concentrations. 17,22,29 Whether these suppressed resting levels of CRP increase an individual's susceptibility to infection remains to be investigated.…”

Section: Discussionsupporting

confidence: 44%

“…Whilst numerous studies have shown the APP C-reactive protein (CRP) to be significantly elevated following exercise, 18,21,26,27 there still remain a large number of acute phase reactants that have not been thoroughly investigated. Therefore, the aims of this study were firstly to confirm the reported increases in CRP following a prolonged, strenuous bout of exercise, and secondly to monitor alterations in less researched acute phase reactants, up to 3 days after an ultramarathon.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Alterations in acute-phase reactants (CRP, rheumatoid factor, complement, Factor B, and immune complexes) following an ultramarathon

Semple

Smith

McKune

et al. 2004

S. Afr. j. sports med.

View full text Add to dashboard Cite

Objectives. The human body initiates an acute phase response (APR) in response to a wide range of homeostatic disturbances. This complex series of reactions serves to activate repair processes and prevent ongoing tissue damage. An important aspect of the APR is the de novo synthesis of acute phase proteins (APP), many of which have not been thoroughly investigated. Main outcome measures.Alterations in CRP (C-reactive protein), C1est, C3, C4, C6, rheumatoid factor (RF) and Factor B were determined before and after an ultramarathon. Data were analysed using a one-way analysis of variance comparing values to pre-exercise levels. Significance was set at p < 0.05.Design. Venepunctures were performed on athletes participating in an ultramarathon (90 km) 24 hours before, immediately post-exercise (IPE), and 3h, 24h and 72h after the race. Serum was stored at -80°C until analysed. CRP levels in serum were assessed using the N Latex CRP kit. The levels of circulating immune complexes (CIC) were determined using particle-enhanced nephelometry. Complement proteins C1est, C3, C4 and RF were measured using laser nephelometry. C6 and Factor B were determined by radial immunodiffusion. Results. CRP was significantly elevated IPE (58%), 3hpost (77%), 24h post (87%) and 72h post (69%). Pre-race CRP levels were above the normative range (5.10 ± 3.08 mg/l), C6 was significantly elevated (p < 0.05) at 24h post (7.8%) and 72h post (8.8%) exercise. Factor B was significantly elevated (p < 0.05) at 72h post exercise (12.8%). RF was significantly elevated at 72h post exercise (6.7%). Conclusion.Significant increases in selected acutephase reactants occur several days after the exercise event. In addition, as indicated by elevated resting levels of CRP, the athletes began the race with some degree of inflammation, presumably as a result of the cumulative training and racing mileage in preparation for the ultramarathon.

show abstract

Section: Discussionsupporting

confidence: 44%

Section: Introductionmentioning

confidence: 99%

Alterations in acute-phase reactants (CRP, rheumatoid factor, complement, Factor B, and immune complexes) following an ultramarathon

Semple

Smith

McKune

et al. 2004

S. Afr. j. sports med.

View full text Add to dashboard Cite

show abstract

“…Acute muscle injury resulting from strenuous exercise 21 or myocardial infarction 22 has been shown to initiate the acute phase response. Based on similarities with malignant hyperthermia, it has been proposed that patients with neuroleptic malignant syndrome may have abnormal calcium channels in skeletal muscle.…”

Section: Muscle Breakdownmentioning

confidence: 99%

Neuroleptic malignant syndrome: a neuroimmunologic hypothesis

Anglin¹,

Rosebush²,

Mazurek³

2010

Canadian Medical Association Journal

View full text Add to dashboard Cite

“…Human plasma collected immediately (1 hr) after exercise was injected intraperitoneally into rats, causing a significant elevation of core temperature in those animals (Cannon & Kluger, 1983). Taylor et al (1987) also sampled volunteers from a triathlon event involving canoeing, cycling, and running. Data showed exercise training was associated with induction of acute-phase reaction as evidenced by a decrease in serum iron concentration and an increase in C-reactive protein.…”

Section: Long-term Exercise Training Selectively Alters Serum Cytokinmentioning

confidence: 99%

Long-Term Exercise Training Selectively Alters Serum Cytokines Involved in Fever

Rowsey

Metzger

Carlson

et al. 2009

Biological Research For Nursing

View full text Add to dashboard Cite

Long-term exercise training selectively alters serum cytokines involved in fever. Chronic exercise training has a number of effects on the immune system that may mimic the physiological response to fever. Female rats that voluntarily exercise on running wheels develop an elevated daytime core temperature after several weeks of training. It remains to be seen whether the elevation in daytime temperature involves inflammatory patterns characteristic of an infectious fever. We assessed whether chronic exercise training in the rat would alter levels of cytokines involved in fever. Female Sprague Dawley rats at 45 days of age weighing 90—110 g were divided into two groups (exercise and sedentary) and housed at an ambient temperature of 22°C. Interleukin-1 beta (IL-1β), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor alpha (TNF-α), iron, and zinc levels were analyzed. Rats underwent 8 weeks of exercise on running wheels. Exercise led to altered levels of some key cytokines that are involved in fever. Exercise animals had significantly higher IL-1β levels and lower IL-10 levels compared to sedentary animals. Although IL-6 levels were slightly lower in the exercise animals, these levels were not significantly affected by training. TNF-α activity was similar in the two groups. Training also led to a slight increase in serum zinc and decrease in serum unsaturated iron binding capacity (UIBC). The data suggest that chronic exercise training evokes immune responses that mimic some, but not all, aspects of fever. This may explain why exercise leads to elevated daytime core temperature.

show abstract

Hematologic, iron-related, and acute-phase protein responses to sustained strenuous exercise

Cited by 107 publications

References 0 publications

Alterations in acute-phase reactants (CRP, rheumatoid factor, complement, Factor B, and immune complexes) following an ultramarathon

Alterations in acute-phase reactants (CRP, rheumatoid factor, complement, Factor B, and immune complexes) following an ultramarathon

Neuroleptic malignant syndrome: a neuroimmunologic hypothesis

Long-Term Exercise Training Selectively Alters Serum Cytokines Involved in Fever

Contact Info

Product

Resources

About