Neuroleptic malignant syndrome: a neuroimmunologic hypothesis

Anglin, Rebecca; Rosebush, Patricia I.; Mazurek, Michael F.

doi:10.1503/cmaj.091442

Cited by 40 publications

(47 citation statements)

References 31 publications

(30 reference statements)

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“…The slower post-calving decrease of the IL-6 response to the LPS stimulation compared to IL-1␤ can be due to the higher sensitivity of some population of leukocytes to release IL-6. This effect could be mediated by monocytes, which often show a marked increase after calving (O'Boyle et al, 2012) and produce preferentially IL-6 (Anglin et al, 2010). Our results also suggest that differences exist in the sensitivity of immune cells in accordance to the dose of LPS.…”

Section: Production Of Il-1ˇ and Il-6 After Ex Vivo Challenge With Lpssupporting

confidence: 54%

Assessment of immune response in periparturient dairy cows using ex vivo whole blood stimulation assay with lipopolysaccharides and carrageenan skin test

Jahan

Minuti

Trevisi

2015

Veterinary Immunology and Immunopathology

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Section: Production Of Il-1ˇ and Il-6 After Ex Vivo Challenge With Lpssupporting

confidence: 54%

Assessment of immune response in periparturient dairy cows using ex vivo whole blood stimulation assay with lipopolysaccharides and carrageenan skin test

Jahan

Minuti

Trevisi

2015

Veterinary Immunology and Immunopathology

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“…NMS can be a fatal disease which occurs in 0.07-3.23% of patients using antipsychotic drugs, with a considerably high mortality rate of about 10% [7,18,19]. There were 11 cases (20.8%) fulfilling Levenson's criteria in this study [8].…”

Section: Discussionmentioning

confidence: 93%

Excessive Sweating is a Predictive Factor for Serious Consequences of Rhabdomyolysis Not Requiring Renal Replacement Therapies on Admission

Tago¹,

Furukawa²,

Naito³

et al. 2015

Gen Med (Los Angel)

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Objective: Rhabdomyolysis is a serious syndrome which may lead to acute kidney injury and even death. However, reliable factors for predicting the prognosis of this condition, especially regarding patient's physical findings, remain to be clarified. Methods:We retrospectively analyzed charts of patients who were clinically suspected of rhabdomyolysis with high serum creatine kinase on admission to the Department of General Medicine, Saga University Hospital, Japan from 2006-2013. Patients were divided into two groups, those progressing to serious consequences of death or acute kidney injury requiring renal replacement therapies during hospitalization (Group A) and those not progressing to such conditions (Group B). We compared background characteristics, symptoms, signs, and blood chemistry between both groups.Results: A total of 53 Japanese patients were enrolled (men, 60.4%; mean age 58.6 years). Group A consisted of five cases. According to univariate analysis, only the finding of excessive sweating on admission was related to the serious consequences (odds ratio 31.33, 95% confidence interval 2.17-450.07, p<0.05). Conclusions:Excessive sweating on admission is a useful indicator to predict the prognosis of serious consequences of rhabdomyolysis.

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“…It is a serious and potentially fatal adverse effect of neuroleptic medications and considered as idiosyncratic reaction to drugs 10 11. Though dopamine receptor blockade been postulated as mechanism responsible for NMS features owing to antidopaminergic drugs till date,12 Anglin et al 13 proposed a neuroimmunological hypothesis for NMS. NMS is associated with a profound and precipitous decrease in serum iron levels, which is a key feature of the immunological cascade known as the acute phase response 13 14.…”

Section: Discussionmentioning

confidence: 99%

Combination of Steven-Johnson syndrome and neuroleptic malignant syndrome following carbamazepine therapy: a rare occurrence

et al. 2013

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Stevens-Johnson syndrome (SJS) is a severe, episodic, acute mucocutaneous reaction that is most often elicited by drugs and occasionally by infections. The drugs commonly implicated as the cause of SJS are anticonvulsants, sulfonamides, non-steroidal anti-inflammatory drugs and antibiotics. Carbamazepine (CBZ) has been commonly implicated in SJS. Neuroleptic malignant syndrome (NMS) is a rare, life-threatening but potentially treatable condition. Among the neuroleptics, haloperidol (parenteral) is implicated as a most common drug for NMS. Though rare, association of NMS with CBZ and association of NMS with toxic epidermal necrolysis (TEN) in a single patient after administration of neuroleptics has been reported in the literature before. However, a combination of NMS and SJS in a single patient after administration of CBZ has not been reported so far. We present a patient with seizure who developed SJS and NMS following administration of CBZ.

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Neuroleptic malignant syndrome: a neuroimmunologic hypothesis

Cited by 40 publications

References 31 publications

Assessment of immune response in periparturient dairy cows using ex vivo whole blood stimulation assay with lipopolysaccharides and carrageenan skin test

Assessment of immune response in periparturient dairy cows using ex vivo whole blood stimulation assay with lipopolysaccharides and carrageenan skin test

Excessive Sweating is a Predictive Factor for Serious Consequences of Rhabdomyolysis Not Requiring Renal Replacement Therapies on Admission

Combination of Steven-Johnson syndrome and neuroleptic malignant syndrome following carbamazepine therapy: a rare occurrence

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