Hematological and Biochemical Profile of Patients Suffering from Non-Atopic Asthma

Ejaz, Samina; Nasim, Faiz ul Hassan; Ashraf, Muhammad; Ahmad, Sami

doi:10.21767/2577-0578.10006

Cited by 11 publications

(11 citation statements)

References 72 publications

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“…It has been reported that human serum albumin (HSA) concentrations are altered in patients with asthma (Blanchard et al, 1992;Shima and Adachi, 1996;Picado et al, 1999;Vural and Uzun, 2000;Misso et al, 2005;Ejaz et al, 2017). The serum albumin concentration is reduced to 41 g/l in patients with asthma (Blanchard et al, 1992).…”

Section: Disease Modelmentioning

confidence: 99%

“…The changes in serum albumin concentration occurring in asthma can potentially affect the unbound drug concentrations, particularly for the drugs with low hepatic clearance. Therefore, the changes in serum albumin levels should be considered while describing the pharmacokinetics (PK) of drugs being administered in asthma (Blanchard et al, 1992;Shima and Adachi, 1996;Picado et al, 1999;Vural and Uzun, 2000;Misso et al, 2005;Ejaz et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Investigating the Role of Altered Systemic Albumin Concentration on the Disposition of Theophylline in Adult and Pediatric Patients with Asthma by Using the Physiologically Based Pharmacokinetic Approach

Rasool

Khalid

Imran

et al. 2020

Drug Metabolism and Disposition

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Theophylline is commonly used for the treatment of asthma and has a low hepatic clearance. The changes in plasma albumin concentration occurring in asthma may affect the exposure of theophylline. The aim of the presented work was to predict theophylline pharmacokinetics (PK) after incorporating the changes in plasma albumin concentration occurring in patients with asthma into a physiologically based pharmacokinetic (PBPK) model to see whether these changes can affect the systemic theophylline concentrations in asthma. The PBPK model was developed following a systematic model building approach using Simcyp. The predictions were performed initially in healthy adults after intravenous and oral drug administration. Only when the developed adult PBPK model had adequately predicted theophylline PK in healthy adults, the changes in plasma albumin concentrations were incorporated into the model for predicting drug exposure in patients with asthma. After evaluation of the developed model in the adult population, it was scaled to children on physiologic basis. The model evaluation was performed by using visual predictive checks and comparison of ratio of observed and predicted (R obs/Pre ) PK parameters along with their 2-fold error range.The developed PBPK model has effectively described theophylline PK in both healthy and diseased populations, as R obs/Pre for all the PK parameters were within the 2-fold error limit. The predictions in patients with asthma showed that there were no significant changes in PK parameters after incorporating the changes in serum albumin concentration. The mechanistic nature of the developed asthma-PBPK model can facilitate its extension to other drugs. SIGNIFICANCE STATEMENTExposure of a low hepatic clearance drug like theophylline may be susceptible to plasma albumin concentration changes that occur in asthma. These changes in systemic albumin concentrations can be incorporated into a physiologically based pharmacokinetic model to predict theophylline pharmacokinetics in adult and pediatric asthma populations. The presented work is focused on predicting theophylline absorption, distribution, metabolism, and elimination in adult and pediatric asthma populations after incorporating reported changes in serum albumin concentrations to see their impact on the systemic theophylline concentrations.

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Section: Disease Modelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Investigating the Role of Altered Systemic Albumin Concentration on the Disposition of Theophylline in Adult and Pediatric Patients with Asthma by Using the Physiologically Based Pharmacokinetic Approach

Rasool

Khalid

Imran

et al. 2020

Drug Metabolism and Disposition

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“…Arterial O 2 may fall when treatment of acute exacerbation of asthma begun; this may be due to drug- induced pulmonary vascular dilation. 35 Atherosclerosis is triggered by endothelial destruction due to mechanical, chemical, and biological factors. 36 As the result of this inflammatory response occur and the adhesion molecules will be produced due to the stimulation of endothelial cells, macrophages, and vascular smooth muscle cells which stimulate the entering of monocytes into subendothelial space.…”

Section: Discussionmentioning

confidence: 99%

Asthma in Relation to Coronary Heart Disease: A Systematic Review and Meta-analysis

Mishra¹,

Hisalkar²,

Mallick³

2021

Indian Journal of Medical Biochemistry

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Aim and background: Asthma is a clinical condition in which constriction of the airway occurs. It is a heterogeneous syndrome that manifesting different phenotypes. Coronary artery disease makes the arteries hardened and inflamed. Similarly, airway swelling occurs in asthma. Lipid accumulation and inflammation are the two common characteristics of coronary artery diseases. Therefore, many authors have described higher cardiovascular disease (CVD) risk in asthmatics. Materials and methods: The search strategy selected 10 published articles that were related to asthma and coronary artery disease and published from May 2004 to April 2018. Results: In this study, the pooled analysis indicated that asthma overall was significantly associated with CHD [OR 2.26 (1.45, 3.52), p = 0.0003]. The values for heterogeneity test were higher (I 2 = 99%, p < 0.00001). Discussion: In this pooled analysis, we found that asthmatic patients have associated with a higher risk for coronary heart disease. Similarly, several previous studies also supported a positive association between asthma and the incidence of coronary heart disease.

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“…Bronchial asthma exacerbations are episodes described by progressive increase in symptoms of cough, wheezing, shortness of breath, and/or chest tightness, with a progressive decrease in lung function [1]. Few tests are being used for diagnosis of asthma, but at present, no established biomarker is available that may be used for diagnosis and prognosis of asthma [2]. Platelet indices and C-reactive protein (CRP) are markers that reflect a systemic inflammatory response [3].…”

Section: Introductionmentioning

confidence: 99%

Assessment of bronchial asthma exacerbation: the utility of platelet indices

et al. 2019

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Background Activated platelets and platelet indices have a vital role in bronchial hyper-responsiveness, bronchoconstriction, bronchial inflammation, airway remodeling, angiogenesis, allergic reactions, and repair and renewal of tissues; platelets contain mediators that lead to inflammatory response. AimThe aim was to assess the use of platelet indices [mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), and platelet large cell ratio (PLCR)] as cheap and readily available biomarkers for bronchial asthma exacerbation.Patients and methods A case-control study involved 45 bronchial asthma female patients during both stable and exacerbation phases, and 45 age-matched healthy female patients as a control group. Measurements of platelet counts, MPV, PDW, PCT, PLCR, C-reactive protein (CRP), spirometric indices, and arterial blood gases were performed for all participants.Results The MPV and PDW were significantly lower, whereas the PCT and PLCR were considerably higher in exacerbation phase compared with stable phase and in stable phase in comparison with controls (P<0.001). The MPV and PDW were negatively correlated with white blood cells, PaCO 2 , symptoms duration, and hs-CRP (high sensitive), with positive correlation with forced expiratory volume in the first second and PaO 2 (P<0.001). PCT and PLCR were positively correlated with white blood cells, PaO 2 , and symptoms duration, and negatively correlated with forced expiratory volume in the first second, symptoms duration, and hs-CRP (P<0.001). ConclusionThe platelet indices were altered in exacerbation phase compared with stable phase and control group. Therefore, clinicians should not ignore interpreting platelet indices during asthma exacerbation, especially as these tests are simple, readily available, and of lower cost. It appears that measurement of the platelet indices is a valuable indicator of asthma severity/activity and appears as a useful screening test for asthma exacerbation.

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Hematological and Biochemical Profile of Patients Suffering from Non-Atopic Asthma

Cited by 11 publications

References 72 publications

Investigating the Role of Altered Systemic Albumin Concentration on the Disposition of Theophylline in Adult and Pediatric Patients with Asthma by Using the Physiologically Based Pharmacokinetic Approach

Investigating the Role of Altered Systemic Albumin Concentration on the Disposition of Theophylline in Adult and Pediatric Patients with Asthma by Using the Physiologically Based Pharmacokinetic Approach

Asthma in Relation to Coronary Heart Disease: A Systematic Review and Meta-analysis

Assessment of bronchial asthma exacerbation: the utility of platelet indices

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