Hematological and serum biochemical values in cynomolgus monkeys anesthetized with ketamine hydrochloride

Kim, Choong-Yong; Lee, Hyun Sook; Han, Sang‐Ik; Heo, Jeong‐Doo; Kwon, Myung-Sang; Ha, Chang-Su; Han, Sangsoo

doi:10.1111/j.1600-0684.2005.00097.x

Cited by 63 publications

(60 citation statements)

References 8 publications

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“…An increase in this ratio indicates a reduction in immune function, and is related to stress in primates (e.g. Kim et al, 2005). Blood cell counts were available for 28 males and 31 females.…”

Section: Quantifying Immune Statusmentioning

confidence: 99%

Is Brightest Best? Testing the Hamilton-Zuk Hypothesis in Mandrills

et al. 2009

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The full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. discovered about the signal function of coloration in male and female mandrills from our long-term studies of a semi-free-ranging colony in Franceville, Gabon and test the predictions of the Hamilton-Zuk hypothesis -that bright coloration is condition dependent, and that only individuals of superior quality will be able to express color fully -in this species. We compare measures of facial coloration in both sexes with parasite load (using fecal analysis over one annual cycle), immune status (hematological parameters), neutral genetic diversity (microsatellite heterozygosity) and major histocompatability (MHC) genotype to examine whether red coloration acts as an honest signal of individual quality in mandrills. We found that red coloration was unrelated to parasitism and hematological parameters. Red was also unrelated to genome-wide heterozygosity and MHC diversity, although specific MHC genotypes were significantly related to red. The healthy, provisioned nature of the colony and problems associated with observational, correlational studies restrict interpretation of our data, and it would be premature to draw conclusions as to whether color signals individual quality in mandrills. We conclude with some suggestions for future studies on the signal content of color in mandrills and other primates.

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Section: Quantifying Immune Statusmentioning

confidence: 99%

Is Brightest Best? Testing the Hamilton-Zuk Hypothesis in Mandrills

et al. 2009

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“…A number of foreign studies [3][4][5][6][7]9] present the data on normal glucose levels in rhesus monkeys and cynomolgus macaques depending on gender, age and during pregnancy. However, glucose levels were assessed in the animals under moderate stress, which were not adapted to blood sampling.…”

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confidence: 99%

Blood Glucose Levels in Rhesus Monkeys (Macaca mulatta) and Cynomolgus Macaques (Macaca fascicularis) under Moderate Stress and after Recovery

2013

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We evaluated normal blood glucose levels in two species of monkeys, namely rhesus monkeys (Macaca mulatta) and cynomolgus macaques (Macaca fascicularis) kept in the Breeding Center of the Institute of Medical Primatology. The animals were either under moderate stress due to catching or after recovery of defensive and orienting reactions by habituation to the blood sampling. Based on these data, seasonal, gender- and age-dependent variations in glucose levels were found. Glucose levels in rhesus monkeys accustomed to blood sampling procedures were shown to be substantially lower compared with those in non-adapted gender- and age-matched animals.

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“…Furthermore, ketamine administration generally promotes an increase in serum cholesterol levels [95,96] and changes in serum triglyceride levels [97,98]. Studies conducted in different species of monkeys exposed to ketamine promoted both cholesterol and triglycerides increase in Macaca fascicularis [99], or the opposite effect, in Macaca radiata [100]. Thus, it is possible to suggest that the ketamine and/or ethanol treatment can promote synergistic or even antagonistic effects in the serum lipid markers.…”

Section: Discussionmentioning

confidence: 99%

Toxic and Immunotoxic Evaluation of Ketamine and/or Ethanol in Rats During 28 Days

Mendes

Simon

Hueza

2017

Int J Pharm Pharm Sci

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Objective: Studies have shown that ketamine (K) and ethanol (E) have immunomodulatory activity; however, few studies were performed with concomitant treatments. Thus, we evaluated the toxic and immunotoxic effects of this association.Methods: Wistar rats were distributed into four groups (n=8/group), each receiving one of the following treatments, for 28 d: K group (15 mg/kg of ketamine, intraperitoneally); E group [1.0 ml of ethanol 10% (approximately 0,08g/rat), gavage]; KE group, receiving both treatments; and Control (Co) group, receiving only vehicles. On day 29, animals were euthanized for biochemical, hematological, histopathological and immunological evaluation. Results:Although the experimental conditions did not elicit changes on immune parameters, some biochemical alterations were detected in the different groups. Even in the absence of nutritional and histopathological changes, or renal and hepatic markers that could indicate tissue damage, a reduction on alkaline phosphatase levels in rats from K and KE groups was observed. Moreover, changes in lipid markers [cholesterol, triglycerides and high-density lipoproteins (HDL)] were found in the different groups studied, suggesting that K and E could promote a synergic/antagonistic effect. Conclusion:In conclusion, despite biochemical alterations promoted by K and E, associated or not, the doses here employed did not promote immunotoxic effects on rats treated for 28 d. (response to the suggestion in the end of the paper).

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Hematological and serum biochemical values in cynomolgus monkeys anesthetized with ketamine hydrochloride

Cited by 63 publications

References 8 publications

Is Brightest Best? Testing the Hamilton-Zuk Hypothesis in Mandrills

Is Brightest Best? Testing the Hamilton-Zuk Hypothesis in Mandrills

Blood Glucose Levels in Rhesus Monkeys (Macaca mulatta) and Cynomolgus Macaques (Macaca fascicularis) under Moderate Stress and after Recovery

Toxic and Immunotoxic Evaluation of Ketamine and/or Ethanol in Rats During 28 Days

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