Hematological changes in malaria: A comparative study

Akhtar, Dr Shamim

doi:10.9790/3008-0241519

Cited by 31 publications

(40 citation statements)

References 13 publications

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“…78.4% of the cases studied by UM Jadhav et al[21] which was also comparable to the present study. In present study most common finding was Normocytic normochromic RBCS 38.11% comparable to 47.3% found in Shamim Akhtar et al[22] study. Next common finding was normocytic hypochromic RBCS 31.62% (185), which was comparable to Shamim Akhtar et al[22] study.…”

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confidence: 84%

Study of haematological parameters in malaria: a prospective study

Babariya¹,

Parmar²

2020

Trop J Pathol Microbiol

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Background: A blood parasites plasmodia is responsible for malaria hence there are haematological alterations in malaria. The haematological changes that have been reported to accompany malaria include anaemia, thrombocytopenia, leucocytosis and leucopenia. Methods: Total 585 smear positive malaria cases were taken and various haematological parameters were studied. Results: Out of 585 smear positive cases, P. vivax was positive in 422 (72%) cases, while P. falciparum was positive in 160 (27%) cases and mixed infection was found in 3 (1%) cases. Anaemia was seen in 420 (71.79%) cases. Normocytic normochromic blood picture was the most common type in anaemic patients 223 (38.11%). Next common finding was Normocytic hypochromic RBCs 185 (31.62%). Microcytic hypochromic RBCs found in 152 (25.98%) cases. Thrombocytopenia was seen in total 490 (83.76%) of the patients. Moderate thrombocytopenia was more common and present in 409 (70%) of patients while Severe thrombocytopenia was seen in 81 (13.84%) of cases. In falciparum malaria thrombocytopenia was present in 90% of the patients while it was present in 81.27% of the patients in vivax malaria. 129 cases (22.05%) shows leucopoenia out of which 81 (13.84%) belong to P. vivax, 45 (7.69%) belong to P. falciparum and 3 (1%) were belong to mixed infection. Total Leucocyte Count was normal in 77.95 % of the patients. Conclusions: Various haematological findings can help in early diagnosis of malaria which is essential for timely and appropriate treatment which can limit the morbidity and prevent further complications.

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confidence: 84%

Study of haematological parameters in malaria: a prospective study

Babariya¹,

Parmar²

2020

Trop J Pathol Microbiol

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“…Many study showed leucopenia, leucocytosis, neutrophilia, eosinophilia and monocytosis. 3,4 Thrombocytopenia is also well recognized and frequent complication of both P. falciparum and P. vivax malaria and its presence in patients with acute febrile illness increases probability of malaria. 5 In India incidence of thrombocytopenia reported in a range from 24% to 94% in various literature.…”

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confidence: 99%

Changes in WBC and platelet count in patients with malaria: a hospital based comparative study

et al. 2013

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Introduction: Malaria is one of the most common infectious diseases of tropics. It presents with varied clinicopathological manifestations. Most of the complication in malaria occurs due to various hematological abnormalities. Present study was aimed to find out abnormalities in WBC and platelet counts in patients with malaria. Methods: A total 135 patients either hospitalized or treated on an outpatient basis were included in the study after positive identification for malarial parasites on Giemsa stained PSMP smears. WBC and platelet count was carried out on 3 part hematology analyzer (Sysmax KX 21). WBC count less than 4000/cumm was considered as leucopenia and platelet count less than 150000/cumm was considered as thrombocytopenia. Results: The present study includes 135 patients with malaria from which 72.59% of subjects were male and 27.41% of subjects were female. P. falciparum was present in 68.89% of cases, P. vivax in 28.15% of cases. Majority of patients had normal leucocyte count (97.03%). Neutrophilia with lymphopenia was observed in both species of malaria in our study. Thrombocytopenia was observed in89.62% of cases in malaria. Thrombocytopenia in P. falciparum was found in 92.48% of cases and in P. vivax it was 81.57% of cases. Conclusion: Present study did not show any significant change in WBC count. Present study showed neutrophilia with relative lymphopenia in both group of malaria. Incidence of thrombocytopenia was observed in both species of malaria without any statistical significance. [Int J Res Med Sci 2013; 1(4.000): 401-403

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“…15 Akhtar S et al who compared the hematological changes in malaria and observed that the 70% of the patient had thrombocytopenia, 94% anemia, 12% lymphopenia and 17% monocytosis, Eosinophilia was 12.16% and basophil count was normal in both groups. 16 Agravat AH and Dhruva GA reported that the P. Falciparum as the most common species specific malaria. Most of the infected cases showed anemia, elevated erythrocyte sedimentation rate (ESR), and thrombocytopenia as common hematological changes.…”

Section: Discussionmentioning

confidence: 99%

A study of haematological profile of malaria in a tertiary care centre of western Uttar Pradesh, India

Prasad¹,

Lata²,

Hussain³

2018

Int J Contemp Pediatr

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Background: Malaria is a major health problem in tropics with a high morbidity and mortality. Malaria causes wide spectrum of manifestation both clinical as well as hematological. A variety of haematological alterations like progressively increasing anaemia, thrombocytopenia, leucocytosis or leukopenia and rarely disseminated intravascular coagulopathy (DIC) have been reported in malaria. Though clinical manifestation has been widely studied but there is paucity of work in hematological abnormality.Methods: The hospital based observational study was conducted in the Department of Paediatrics, Shri Rammurti Smarak Insitute of Medical Sciences (SRMSIMS), Bareilly. Ninety-eight cases were positive for malaria by peripheral smear or by rapid diagnostic test for malaria or by both.Results: In the present study, prevalence of malaria found to be (11.6 %). Out of 98 cases, 60 were males, majority of cases belonged to 9-12 years of age, followed by 4-8 years of age. Male:Female ratio is 1.57:1. There was neutrophilic predominance and low monocyte count in cases positive for plasmodium falciparum malaria. All the patients had microcytic hypochromic anemia as per mean of MCV. In haematological profiles of malaria neutrophil and monocyte showed statistically significant variations (P value ≤0.001)Conclusions: Anemia is the most common hematological abnormality. There was neutrophilic predominance and low monocyte count in cases positive for malaria which is highly significant. All the patients had microcytic hypochromic anemia as per mean of MCV. Profound thrombocytopenia is very common in malaria.

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Hematological changes in malaria: A comparative study

Cited by 31 publications

References 13 publications

Study of haematological parameters in malaria: a prospective study

Study of haematological parameters in malaria: a prospective study

Changes in WBC and platelet count in patients with malaria: a hospital based comparative study

A study of haematological profile of malaria in a tertiary care centre of western Uttar Pradesh, India

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