Hematological disorders in preterm newborns born to mothers with pregnancy-induced hypertension

Arce-López, Karina L.; Iglesias-Leboreiro, José; Bernárdez-Zapata, Isabel; Rendón-Macı́as, Mario Enrique; Madrazo, Maria R. Miranda

doi:10.24875/bmhim.22000069

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…The incidence of thrombocytopenia in neonates born to mothers with gestational hypertension was 13.3%, which is similar to that reported in previous studies (6.7-11.1%) [20,21]. However, the precise mechanism by which maternal gestational hypertension increases neonatal thrombocytopenia remains unclear.…”

Section: Discussionsupporting

confidence: 87%

Effects of Pregnancy-Induced Hypertension on Early-Onset Neonatal Thrombocytopenia

Ye,

Zhou,

et al. 2023

Preprint

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Background. Gestational hypertension and preeclampsia are potentially linked to similar pathophysiological processes. Maternal preeclampsia increases the occurrence of early-onset neonatal thrombocytopenia. We hypothesized that maternal gestational hypertension may impact the incident early-onset neonatal thrombocytopenia. Methods. We included 538 neonates, comprising 318 and 220 neonates born to healthy mothers and those with pregnancy-induced hypertension. The minimum platelet count within 72 hours of birth was recorded for these neonates. The incidence of early-onset thrombocytopenia in neonates in relation to maternal gestational hypertension, preeclampsia, and health status was evaluated. Logistic regression analysis was conducted to assess the relationship between maternal gestational hypertension and the risk of early-onset neonatal thrombocytopenia. Results. The incidence of early-onset thrombocytopenia was significantly higher in neonates born to mothers with preeclampsia than in those born to mothers with gestational hypertension or healthy mothers. Significant differences were observed among the three groups (30.0% vs. 13.3% vs. 7.9%, p < 0.001). Maternal gestational hypertension (OR = 2.55, 95%CI 1.10–5.91) increased the risk of early-onset neonatal thrombocytopenia when compared to healthy mothers. Conclusions. Maternal gestational hypertension increases the occurrence of early-onset neonatal thrombocytopenia. Therefore, we recommend conducting platelet count screening at the early stages of neonates of mothers with gestational hypertension.

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Section: Discussionsupporting

confidence: 87%

Effects of Pregnancy-Induced Hypertension on Early-Onset Neonatal Thrombocytopenia

Ye,

Zhou,

et al. 2023

Preprint

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“…Eclampsia, on the other hand, is a more severe form of preeclampsia that is accompanied by neurological symptoms such as seizures, hyperreflexia (exaggerated reflexes), headache, visual disturbances, or coma. (Arce-López et al, 2022) Maternal problems associated with…”

Section: Introductionmentioning

confidence: 99%

Effect of Benson Relaxation Technique on Blood Pressure and Anxiety among Women with Pregnancy Induced Hypertension.

Farhat,

Ahmed,

Atia

et al. 2024

International Egyptian Journal of Nursing Sciences and Research

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Pregnancy-Induced Hypertension Pathophysiology and Contemporary Management Strategies: A Narrative Review

Agarwal,

Agrawal,

Singhal

et al. 2024

Cureus

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In the case of PIH, the history is the story of gradually developing awareness and the gradual formation of requisite knowledge. The development of the sphygmomanometer, or blood pressure cuff, in the late 1700s, provided the basis for modern systematic blood pressure reporting for Gravid patients. In the following years and over a few decades, the relationship between high blood pressure and these complications, such as preeclampsia and eclampsia, became clearer. The hypertensive disease was categorized by the American Committee on Maternal Welfare in 1952, which included PIH, chronic hypertension, and preeclampsia. Today, attention is being paid to the identification of such factors, the search for ways to enhance the treatment of diseases, methods for their diagnosis, and the enhancement of pregnancy outcomes. Pregnancy can cause high blood pressure in two of the following ways: preeclampsia and gestational hypertension. These conditions are both part of something called pregnancy-induced hypertension (PIH). In the world, most problems for moms and babies during pregnancy come from PIH. To help both mom and baby, we need to know a lot about what causes it, how to manage it, and how to watch the baby carefully. Aspects like immune responses, the environment, and genes all mix to cause PIH. They make the placenta not work right. When the cells that help the placenta grow don't do their job well, when blood vessels are stiff, when there's too much stress on the body, or when there's not a good balance of chemicals that help build blood vessels, things can get bad. Blood vessels all over the body squeeze tight, blood flow goes down, and blood pressure goes up. That can make a lot of organs stop working right and stop the baby from healthy growth. Various studies concluded that PIH severely limits the blood flow to the placenta and thus contributes to reduced fetal growth. It showed that compared to other hospitals, women who experience PIH are more likely to give birth early before the baby is ready, that is, before 37 weeks, and may cause further health complications to the baby. This normally makes the offspring have low birth weight and exposes them to many complications in infancy and the future in case they are born to mothers with PIH. In severe cases, PIH may lead to the death of the infant either by stillbirth or immediately after birth. The researchers have noted several predisposing factors to PIH, which include histories of elevated blood pressure, diabetes, being overweight or obese, and having a family history of PIH. Educating women about the presence of PIH and its causes can help them consult health facilities early, thus helping leaders in achieving better pregnancy results.

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Hematological disorders in preterm newborns born to mothers with pregnancy-induced hypertension

Cited by 3 publications

References 14 publications

Effects of Pregnancy-Induced Hypertension on Early-Onset Neonatal Thrombocytopenia

Effects of Pregnancy-Induced Hypertension on Early-Onset Neonatal Thrombocytopenia

Effect of Benson Relaxation Technique on Blood Pressure and Anxiety among Women with Pregnancy Induced Hypertension.

Pregnancy-Induced Hypertension Pathophysiology and Contemporary Management Strategies: A Narrative Review

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