Hematological features in adolescents with periodontitis

Abstract

The aim of this study was to assess whether adolescent cases of periodontitis present with different hemogram findings than control subjects. This case-control study comprised 87 adolescent cases presenting with clinical attachment loss ≥3 mm in at least two teeth and 73 control subjects. Blood samples were obtained by venipuncture and analyzed in an Abbott Cell-Dyn 3,500 hematology analyzer for values of white blood cells and red blood cells, hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, red-cell distribution width, platelets, and mean platelet volume. Hematocrit values were obtained using volume fractions read from capillary tubes. The associations between log-transformed hemogram variables with each of the three exposure variables "case status" (yes/no), a "high percent sites with PD ≥4 mm" (yes/no), and a "high percent sites with BOP" (yes/no) were investigated using multivariate linear regression analyses. Periodontitis cases presented with 5% higher values for the mean platelet volume than did controls. Subjects with a high percent sites with probing depth ≥4 mm had eosinophil counts that were on average 27% lower than among subjects with fewer deepened pockets. They also had 7% higher values for the mean platelet volume than did persons with less pocketing. Eosinophil counts and mean platelet volumes may be associated with the parameters of periodontitis in adolescents. While standard hematological testing did not show abnormalities in adolescents with periodontitis compared to healthy controls, eosinophil counts and mean platelet volumes may reflect periodontal inflammation.

Favourable effects of Bacillus subtilis and Bacillus licheniformis on experimental periodontitis in rats

“…A possible explanation for that would be the release of small but consistent amounts of chemotactic factors into the circulation in patients with periodontitis and consequent eosinophil accumulation at tissue sites (e.g. lymph nodes), reducing the number of circulating eosinophils (Lopez, Loos, & Baelum, 2012). It is also important to emphasize that, although some studies have documented differences in the hematological parameters for subjects with chronic periodontitis compared to healthy subjects, the findings are not always conclusive (Lopez et al, 2012).…”

Systemic administration of probiotics reduces the severity of apical periodontitis

“…Other studies also showed similar results. Leucocytes are involved in defense against pathogens and can be altered when there is local infection since a relationship between bacterial infection and blood cell numbers is commonly observed (L opez et al 2002, Gkrania-Klotsas et al 2010, Yamamoto et al 2011. In contrast, one study performed in rats reported that systemic administration of lactobacilli decreased circulating white blood cells (Flore et al 2010).…”

“…The increasing of white blood cells may mean the presence of infection. Leucocytes are involved in defense against pathogens and can be altered when there is local infection since a relationship between bacterial infection and blood cell numbers is commonly observed (L opez et al 2002, Gkrania-Klotsas et al 2010, Yamamoto et al 2011. Different results reported in the literature may be due to the experimental model, as well as, the probiotic strain used (Mileti et al 2009).…”

Condition of platelet factor of hemostasis system in pathogenesis of chronic periodontitis progression

“…Современное взгляды на патогенетические механизмы хронического пародонтита определяют важную роль не только патологическим изменениям микроциркуляции [4], но и системным нарушениям [5,6]. Ряд авторов при хроническом пародонтите констатирует повышение уровня и активности тромбоцитов крови [7][8][9], но механизм подобного рода изменений в системе гемостаза остается недостаточно изученным [10,11]. Также не до конца ясной остается роль гиперкоагуляции в прогрессировании хронического пародонтита.…”