2003
DOI: 10.1002/micr.10166
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Hematological, hemorheological, immunological, and morphological studies of spleen autotransplantation in mice: Preliminary results

Abstract: Using a spleen autotransplantation model, we conducted hematological, hemorheological, immunological, and morphological studies in mice 6 weeks after splenectomy. Sixty male and female A/J inbred mice were equally divided into 3 groups: 1) SE group, splenectomy was performed; 2) AU group, spleen chips were autotransplanted into the omentum without vascular anastomosis following splenectomy; and 3) C group (controls), no intervention in these mice. At postoperative week 6, the following studies were performed: … Show more

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Cited by 13 publications
(22 citation statements)
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“…The response has been reported to be either unchanged (Resende & Petroianu, 2003;Resende et al, 2002) or increased (Karagülle et al, 2007;Knežević et al, 2002;Miko et al, 2003). As one third of total platelets is physiologically sequestered in the spleen, and spleen is also the site of platelet destruction, it is expected, that after their removal, thrombocytosis will develop.…”
Section: Plateletsmentioning
confidence: 99%
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“…The response has been reported to be either unchanged (Resende & Petroianu, 2003;Resende et al, 2002) or increased (Karagülle et al, 2007;Knežević et al, 2002;Miko et al, 2003). As one third of total platelets is physiologically sequestered in the spleen, and spleen is also the site of platelet destruction, it is expected, that after their removal, thrombocytosis will develop.…”
Section: Plateletsmentioning
confidence: 99%
“…However, total removal of the spleen may lead to side effects such as postsplenectomy infections and sepsis, due to the decreased production of antibodies and phagocytes or thrombosis, due to elevated platelet count in blood (Bessler et al, 2004;Khan et al, 2009;Miko et al, 2003;Timens & Leemans, 1992). Also, many studies report increased count of morphologically abnormal erythrocytes, immature red blood cells and pathologic erythrocyte inclusions in the peripheral blood of various species following splenectomy as a result of the loss of splenic filtrating function (Haklar et al, 1997;Resende et al, 2002;Traub et al, 1987).…”
Section: Introductionmentioning
confidence: 99%
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“…Miko et al 23 used morphologic studies, among other techniques, to evaluate rats submitted to the spleen autotransplantation, six weeks after splenectomy. The omentum was preferred as placed and then was done revascularization studies.…”
Section: Introductionmentioning
confidence: 99%
“…So that, to minimize the consequences of spleen absence, the use of subtotal splenectomy and spleen autotransplantation was stimulated (4,5,6,15,18,22,23,25,31,34,35,41,45) .…”
Section: Introductionmentioning
confidence: 99%