Hematological Indices May Be Useful in the Diagnosis of Systemic Lupus Erythematosus and in Determining Disease Activity in Behçet's Disease

Abstract

Objectives: The aim of this study was to investigate the relationships between clinical features of rheumatic diseases and hematologic indices, including mean platelet volume (MPV), MPV/platelet ratio (MPR), platelet/lymphocyte ratio, and neutrophil/lymphocyte ratio (NLR). Subjects andMethods: Rheumatoid arthritis (RA; n = 91), systemic lupus erythematosus (SLE; n = 51), systemic sclerosis (SSc; n = 39), and Behçet's disease (BD; n = 53) patients, and 55 healthy controls (HC) were enrolled. Hematological indices were calculated and one-way analysis of variance, Mann-Whitney U and χ² tests, and receiver operating characteristic (ROC) analyses were performed. Results: The MPV and MPR were higher in the SLE group than the RA group (p < 0.05 and p < 0.01, respectively). ROC analysis indicated that MPV (area under the curve, AUC, 0.68, 95% CI 0.58-0.77) and MPR (AUC 0.69, 95% CI 0.59-0.78) were sensitive and specific markers for SLE against RA. The NLR was higher in the RA, SLE, and SSc groups compared to the HC group (p < 0.05, p < 0.001, and p < 0.01, respectively). The NLR was higher in the active BD patients than those that were inactive (p = 0.008). Besides, NLR was higher in patients with neuro-BD and patients with active genital ulcers compared to patients without neurological involvement (p < 0.01) and active genital ulcers (p < 0.05). Conclusion: The MPV and MPR were significantly higher in the SLE group than in the RA group. They were also higher in the active than in the inactive BD patients. The MPV and MPR are useful diagnostic tools for SLE, and NLR reflects disease activity in BD. However, further research should be performed to standardize these tools.

Mean Platelet Volume (MPV) as an indicator of disease activity and severity in lupus

“…After reading this article, I have the following suggestions: I think it would be good if the title were more specific (perhaps including such terms as “platelet size” or “platelet volume”).Contrary to what is mentioned in the last paragraph of the Introduction, Rupa-Matysek et al 1 did not include SLE patients in their study.Our team also published an article on this topic 2 , which is not mentioned in the Introduction, even when it appeared online before that of Yolbas et al 3 .I would like to know if the sampling technique was consecutive or random. I'm inclined to think that consecutive (i.e., non-random) sampling was used.…”

Association of Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume with Systemic Lupus Erythematosus Disease Activity: A Meta-analysis

“…One of these was excluded because they included other diseases [31]. Thus, nine articles met the inclusion criteria [3,[10][11][12][13][14][15][16][17] (Table 1, Figure 1). One report contained data on two different groups [12], so we analyzed these studies independently.…”

“…Recent studies have reported the numbers and ratios of complete blood cell (CBC) subgroups in rheumatic diseases [3,4]. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) have recently been investigated as new inflammatory markers for the assessment of inflammation in many inflammatory, cardiovascular, and malignant diseases [5,6].…”

“…Studies on NLR, PLR, and MPV in SLE patients compared to healthy controls, on the relationship between NLR, PLR, and MPV levels and SLE activity, and on the association of NLR with renal involvement in SLE have reported controversial results [3,[10][11][12][13][14][15][16][17]. This may be because of the small sample sizes, low statistical power, and/or the presence of clinical heterogeneity.…”

Comparative mild, moderate and severe effects of Trypanosomiasis and Ancylostomiasis on the Haemogram of Local dog breeds

“…Haematological studies are useful for the diagnosis of both human and animal diseases as well as investigation of the extent of damage to blood [20][21][22]. Haematological profile evaluations are important in assessing the health status of dogs infected with GI helminths [23].…”