Hematological Parameters as Prognostic Biomarkers in Patients with Cardiovascular Diseases

Júnior, José Gildo de Moura Monteiro; Torres, Diogo; Filho, Dário Celestino Sobral

doi:10.2174/1573403x15666190225123544

Cited by 21 publications

(20 citation statements)

References 49 publications

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“…Although previous studies investigated the prognostic roles of individual hematological parameters after STEMI, there were no studies comparing them. 16 –21 In our study, in the same cohort, it was investigated which one had the highest prognostic power using multivariate analysis. As a result, it was observed that some parameters, which were shown to be independent predictors for mortality in the literature, lose their power when adjusted in multivariate analysis.…”

Section: Discussionmentioning

confidence: 99%

Comparing the Prognostic Value of Hematological Indices in Patients With ST Segment Elevation Myocardial Infarction: “A Head to Head” Analysis

et al. 2020

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Although there are reviews and meta-analyses focusing on hematological indices for risk prediction of mortality in patients with ST segment elevation myocardial infarction (STEMI), there are not enough data with respect to direct to head-to-head comparison of their predictive values. We aimed to investigate which hematological indices have the most discriminatory capability for prediction of in-hospital and long-term mortality in a large STEMI cohort. We analyzed the data of 1186 patients with STEMI. In-hospital and long-term all-cause mortality was defined as the primary end point of the study. In-hospital mortality rate was 8.6% and long-term mortality rate 9.0%. Although the neutrophil to lymphocyte ratio (NLR) and age were found to be independent predictors of in-hospital mortality in the multivariate regression analyses; Cox regression analysis revealed that age, ejection fraction, red cell distribution width (RDW), and monocyte to high-density lipoprotein ratio (MHDLr) were independently associated with long-term mortality. Neutrophil to lymphocyte ratio had the highest area under curve value in the receiver operating characteristic curve analyses for prediction of in-hospital mortality. In conclusion, while NLR may be used for prediction of in-hospital mortality, RDW and MHDLr ratio are better hematological indices for long-term mortality prediction after STEMI than other most common indices.

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Section: Discussionmentioning

confidence: 99%

Comparing the Prognostic Value of Hematological Indices in Patients With ST Segment Elevation Myocardial Infarction: “A Head to Head” Analysis

et al. 2020

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“…Thus, NLR value, based on the neutrophil and lymphocyte count, is an integrated reflection of different yet complementary immune pathways and more important than either parameter alone. NLR has been proved higher in both stable coronary artery disease and acute coronary syndrome [23]. Besides, Sato et al [24] suggested that NLR could predict the severity grade independently in patients with acute cholecystitis, which would be important to optimize the treatment and achieve a better prognosis.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in Branch Retinal Vein Occlusion

Zhu

Liu

2019

Journal of Ophthalmology

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Purpose. To evaluate the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio(PLR) value in the development of branch retinal vein occlusion (BRVO)patients. Methods. 81 patients with BRVO and 81 age and sex-matched subjects were recruited as the control group. The BRVO diagnosis was confirmed under comprehensive ophthalmologic examinations. NLR and PLR parameters obtained from peripheral blood were recorded. Results. Both the mean NLR and PLR was significantly higher in the BRVO group compared with the control group (p < 0.001). In ROC analysis, the AUC for NLR was 0.82, and NLR of >2.48 predicted BRVO with a sensitivity of 58% and specificity of 98%. The AUC for PLR was 0.78, and PLR of >110.2 predicted BRVO with a sensitivity of 72% and specificity of 72%. Conclusion. The current study demonstrated that BRVO patients had increased NLR and PLR levels compared with control subjects. The NLR and PLR may be used as independent predictors for identifying risk for the development of BRVO.

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“…Besides, higher PLR has been related to poor prognosis in patients with acute pulmonary embolism 11 . Although it has been also suggested that higher PLR may be a predictor of poor prognosis in cardiovascular diseases, 12‐15 results of previous studies in STEMI patients treated with primary PCI (pPCI) were varied 16‐26 . Therefore, we aimed to summarize the potential prognostic role of PLR for the in‐hospital and long‐term outcomes in STEMI patients treated with pPCI in a meta‐analysis.…”

Section: Introductionmentioning

confidence: 99%

Platelet‐to‐lymphocyte ratio and prognosis in STEMI: A meta‐analysis

Dong

Huang

Liu

2020

Eur J Clin Investigation

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Background Platelet‐to‐lymphocyte ratio (PLR) is a haematological index which reflects increased level of inflammation and thrombosis. We aimed to summarize the potential prognostic role of PLR for the in‐hospital and long‐term outcomes in ST‐segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (pPCI) in a meta‐analysis. Materials and methods Relevant cohort studies were identified by search the PubMed, Cochrane's Library and Embase databases. A random‐effect model was applied to pool the results. In‐hospital and long‐term outcomes were compared between patients with higher and lower preprocedural PLR. Results Eleven cohorts with 12 619 patients were included. Pooled results showed that higher preprocedural PLR was independently associated with increased risk of in‐hospital major adverse cardiovascular events (MACE, risk ratio [RR]: 1.76, 95% confidence interval [CI]: 1.39 to 2.22, P < .001; I2 = 49%), cardiac mortality (RR: 1.91, 95% CI: 1.18 to 3.09, P = .009; I2 = 0), all‐cause mortality (RR: 2.14, 95% CI: 1.52 to 3.01, P < .001, I2 = 24%) and no reflow after pPCI (RR: 2.22, 95% CI: 1.70 to 2.90, P < .001, I2 = 59%). Moreover, higher preprocedural PLR was associated with increased risk of MACE (RR: 1.60, 95% CI: 1.25 to 2.03, I2 = 57%, P < .001) and all‐cause mortality (RR: 2.36, 95% CI: 1.53 to 3.66, I2 = 78%, P < .001) during long‐term follow‐up of up to 82 months after discharge. Conclusions Higher PLR predicts poor in‐hospital and long‐term prognosis in STEMI patients after pPCI.

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Hematological Parameters as Prognostic Biomarkers in Patients with Cardiovascular Diseases

Cited by 21 publications

References 49 publications

Comparing the Prognostic Value of Hematological Indices in Patients With ST Segment Elevation Myocardial Infarction: “A Head to Head” Analysis

Comparing the Prognostic Value of Hematological Indices in Patients With ST Segment Elevation Myocardial Infarction: “A Head to Head” Analysis

Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in Branch Retinal Vein Occlusion

Platelet‐to‐lymphocyte ratio and prognosis in STEMI: A meta‐analysis

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