Hematological Profile In Cases Of Chronic Renal Diseases.

Dewan, P.; Patil, Nanda; Bharti, Mamta

doi:10.9790/0853-1604060103

Cited by 5 publications

(3 citation statements)

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“…Peripheral smear analysis revealed that the predominant morphology of anemia in the studied population was Normocytic Normochromic (91.1%). This finding aligns with the observations of other studies, including those by Chakravarti A et al 14 , Mudiyammanarava NR et al 20 , Dewan P et al 21 , Reza et al 22 , Arun S et al 15 . Additionally, macrocytosis has been associated with increased mortality in hemodialysis CKD patients, as demonstrated by Tennakore KK et al 23 .…”

Section: Discussionsupporting

confidence: 93%

“…This aligns with similar findings in studies conducted by Chinwuba et al 16 , Islam et al 17 , and Bhattacharjee et al 18 . The distribution of hemoglobin levels was categorized into mild, moderate, and severe anemia, revealing statistically significant anemia in Stage 5 CKD patients with hemoglobin levels below 9 gm%, consistent with studies by Chakravarti et al 14 and Dewan et al 19 .…”

Section: Discussionsupporting

confidence: 87%

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Hematological Dynamics in Hemodialysis: A Comprehensive Examination of Patients With Chronic Renal Failure in a Tertiary Care Hospital

Krishna Upadhye,

Dr. Uttam Kumar Aggarwal

2024

EPRA

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Background: Chronic kidney disease (CKD) is a significant health burden in developing countries like India, leading to high morbidity and mortality rates. The study aimed to determine the incidence of anemia among patients with CKD and examine its potential association with other predictive markers. Methods: A cross-sectional observational research was undertaken within a tertiary hospital setting to examine the incidence of hematological abnormalities and explore the association between anemia and its many manifestations in patients with stages 3-5 chronic kidney disease (CKD). The markers for anemia encompassed measurements of hemoglobin percentage (Hb%), mean corpuscular volume (MCV), and examination of peripheral smears. The investigation also examined the correlation between stages of chronic kidney disease (CKD) and red cell distribution width (RDW), thrombocytopenia, leucocyte count, and differential count. Result: The study found that 96.8% of participants displayed symptoms of anemia, characterized by normocytic and normochromic observations on peripheral measures. A significant number of patients (57.3% of them) had a higher total leucocyte count (TLC), but there was no statistically significant link between a higher TLC and the worsening stages of CKD. The mean corpuscular volume (MCV) and platelet levels exhibited a predominantly normal range, with relatively few observed fluctuations. However, there is a positive link between the advancement of CKD and an increase in red cell distribution width (RDW). Conclusion: The study highlights the changes in blood parameters observed in individuals with CKD, with particular attention given to the high occurrence of anemia. The findings underscore the importance of comprehensive iron investigations and the timely identification and intervention of anemia. Adopting a comprehensive strategy that includes regular monitoring of blood parameters, specifically focusing on anemia and iron levels, is crucial for effectively managing and enhancing the overall health of individuals with CKD KEY WORDS- Anemia in CKD, Chronic kidney disease, Iron deficiency anemia

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 87%

Hematological Dynamics in Hemodialysis: A Comprehensive Examination of Patients With Chronic Renal Failure in a Tertiary Care Hospital

Krishna Upadhye,

Dr. Uttam Kumar Aggarwal

2024

EPRA

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“…This is consistent with studies done by Dewan et al, (50% cases) and Chakravarti et al, (55.26%). 5,6 The mean hemoglobin decreased from stage 3(9.87) to stage 5(8.37) and this correlation was statistically significant (p=0.004).…”

Section: Discussionmentioning

confidence: 84%

Study of hematological profile in patients with chronic kidney disease

Panduranga

Perla

2019

Int J Adv Med

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Background: Chronic Kidney Disease (CKD) with its high prevalence, morbidity and mortality, has become an important public health problem. The incidence and prevalence of CKD is increasing worldwide, including India. CKD is associated with a variety of hematological abnormalities, include anaemia, infections and bleeding diathesis. Anaemia is the most consistent hematological abnormality and is associated with poor quality of life and poor cardiovascular outcomes.Methods: A hospital based cross-sectional observational study was done to detect the prevalence of haematological abnormalities, correlation of anaemia with CKD stage and evaluation of iron deficiency. Newly diagnosed CKD (stages 3 to 5) patients were included in this study. Presence of anaemia (Hb%, haematocrit, MCV, peripheral smear), iron deficiency (TSAT, serum ferritin), thrombocytopenia, leucocyte count and coagulation abnormalities (PT, APTT) in different stages of CKD were studied.Results: All the subjects in study group had anaemia which was normocytic and normochromic and of moderate degree in most patients. The severity of anaemia progressed with stage of the disease. Iron deficiency was significantly prevalent (52% in the study population, with transferrin saturation (TSAT) <20%). WBC count was not significantly altered. There was mild thrombocytopenia in a few patients. Bleeding time or other in vitro tests of platelet function were not measured. The coagulation parameters, PT and APTT, were not significantly altered.Conclusions: All CKD patients should be screened for iron deficiency anaemia for its early treatment and to decrease morbidity.

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