Hematopoietic and myeloprotective activities of an acidic Angelica sinensis polysaccharide on human CD34+ stem cells

Efficiency of improved RAPD and ISSR markers in assessing genetic diversity and relationships in Angelica sinensis (Oliv.) Diels varieties of China

“…In addition to effect in ameliorating female reproductive complications, A. sinensis also possess a number of other medicinal or health beneficial activities [4,5]. For example, different extracts or specific active ingredients from A. sinensis show potent anticancer activities [6,7]. Extracted natural products from A. sinensis have been proved successful also against cardiovascular complications, hepatic diseases, inflammation, etc.…”

Study to establish the role of JAK2 and SMAD1/5/8 pathways in the inhibition of hepcidin by polysaccharides from Angelica sinensis

“…Diels, a well-known Chinese herbal medicine, have been used for thousands of years as a hematopoietic, tonic and anti-inflammatory agent for the treatment of menstrual disorders, dysmenorrheal and amenorrhea (Jin et al, 2012). As one of the active components, Angelica sinensis polysaccharide (ASP) has various bioactivities, such as hematopoiesis (Lee et al, 2012), immunomodulation (Liu et al, 2010a), radioprotection (Jin et al, 2012), and anti-tumor activity (Cao et al, 2010). Liu et al (2010b) found that ASP is the major component responsible for the hematopoietic effect of Angelica sinensis (AS).…”

Tumor Inhibition Effects and Mechanisms of Angelica sinensis and Sophorae flavescentis ait Decoction Combined with Cisplatin in Xenograft Mice

“…Angelica sinensis polysaccharides can stimulate the human peripheral blood mononuclear cells (MNCs) to secret GM-CSF and IL-3 and protect the hematopoietic function of CD34(+) cells from myelosuppressive agent (Lee et al, 2012), induce CD34+CD38 cell senescence through up-regulation of p53, p16, p21, and Rb genes and repression of telomerase activity, effectively inhibit human acute myelogenous leukemia (AML) CD34+CD38 stem cell proliferation without suppressing normal hematopoietic stem and progenitor cells . Angelica Sinensis has clinical efficacy in treating radiotherapy-induced pneumonitis and fibrosis through down-expression of TNF-α and TGF-β1 both at mRNA and protein levels (Xie et al, 2006) Radix sophorae flavescentis ait is bitter and cold in traditional Chinese medicine, can clear heat and eliminate dampness, kill parasite, promote urine to be formed, and treat accumulated lump in traditional Chinese medicine.…”