Hematopoietic cell transplantation for myeloid/<scp>NK</scp> cell precursor acute leukemia in second remission

Noguchi, Yusuke; Tomizawa, Daisuke; Hiroki, Haruka; Miyamoto, Satoshi; Tezuka, Mari; Miyawaki, Reiji; Tanaka-Kubota, Mari; Okano, Tubasa; Kobayashi, Chizuko; Mitsuiki, Noriko; Aoki, Yuki; Imai, Kohsuke; Kajiwara, Michiko; Kanegane, Hirokazu; Morio, Tomohiro; Takagi, Motoki

doi:10.1002/ccr3.1506

Cited by 3 publications

(2 citation statements)

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“…( 1 ) in 1997. MNKPL is prevalent in East Asia, similar to other NK neoplasms ( 2 – 4 ). MNKPL is characterized by cells with an immature lymphoblastoid morphology with neither myeloperoxidase (MPO) reactivity nor azurophilic granules.…”

Section: Introductionmentioning

confidence: 92%

“…Myeloid/natural killer (NK) cell precursor acute leukemia (MNKPL) was first proposed to be a leukemia subtype by Suzuki et al (1) in 1997. MNKPL is prevalent in East Asia, similar to other NK neoplasms (2)(3)(4). MNKPL is characterized by cells with an immature lymphoblastoid morphology with neither myeloperoxidase (MPO) reactivity nor azurophilic granules.…”

Section: Introductionmentioning

confidence: 99%

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Myeloid/natural killer (NK) cell precursor acute leukemia as a distinct leukemia type

Nishimura,

Yokoyama,

Naruto

et al. 2023

Sci. Adv.

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Myeloid/natural killer (NK) cell precursor acute leukemia (MNKPL) has been described on the basis of its unique immunophenotype and clinical phenotype. However, there is no consensus on the characteristics for identifying this disease type because of its rarity and lack of defined distinctive molecular characteristics. In this study, multiomics analysis revealed that MNKPL is distinct from acute myeloid leukemia, T cell acute lymphoblastic leukemia, and mixed-phenotype acute leukemia (MPAL), and NOTCH1 and RUNX3 activation and BCL11B down-regulation are hallmarks of MNKPL. Although NK cells have been classically considered to be lymphoid lineage–derived, the results of our single-cell analysis using MNKPL cells suggest that NK cells and myeloid cells share common progenitor cells. Treatment outcomes for MNKPL are unsatisfactory, even when hematopoietic cell transplantation is performed. Multiomics analysis and in vitro drug sensitivity assays revealed increased sensitivity to l -asparaginase and reduced levels of asparagine synthetase (ASNS), supporting the clinically observed effectiveness of l -asparaginase.

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Section: Introductionmentioning

confidence: 92%