2001
DOI: 10.1073/pnas.191362598
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Hematopoietic colony-forming cells derived from human embryonic stem cells

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Cited by 831 publications
(573 citation statements)
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“…These Flk1 + cells are able to differentiate into all types of myeloid and lymphoid progeny [38]. In addition, several groups have shown differentiation of human ES cells into hematopoietic cells [39][40][41]. Lengerke et al [42] showed that BMP signals play two distinct and sequential roles in hematopoietic differentiation from ES cells; they initially induce mesoderm and later specify blood lineages via activation of Wnt signals and the CdxHox pathway.…”
Section: Mesoderm Derivativesmentioning
confidence: 99%
“…These Flk1 + cells are able to differentiate into all types of myeloid and lymphoid progeny [38]. In addition, several groups have shown differentiation of human ES cells into hematopoietic cells [39][40][41]. Lengerke et al [42] showed that BMP signals play two distinct and sequential roles in hematopoietic differentiation from ES cells; they initially induce mesoderm and later specify blood lineages via activation of Wnt signals and the CdxHox pathway.…”
Section: Mesoderm Derivativesmentioning
confidence: 99%
“…To date, while many studies have reported that hESCs could be efficiently induced to differentiate into mesodermal and ectodermal lineages, such as cardiomyocytes [1], endothelial cells [2], blood cells [3] and nerve cells [4], few reports have focused on the conversion of hESCs into endodermal lineages, particularly into pancreatic cell types [5][6][7][8], which may provide a limitless stock of insulin-producing cells to treat type 1 diabetes. Moreover, despite increasing knowledge on pancreatic development, there is still debate regarding the origin of beta cells and the markers that can be used to identify their progenitors [9].…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, many articles are published in which the in vitro and in vivo differentiation of human ESCs is described. Useful cell types such as neurons [24][25][26], cardiomyocytes [27,28], hepatocytes [29,30], pancreatic beta cells [31], endothelial cells [32], blood cells [33,34] and chondrocytes [35] have all been successfully derived in the laboratory. Levenberg and co-workers demonstrated the differentiation of human ESCs on polymeric scaffolds into 3D structures with characteristics of developing neural tissues, cartilage, liver, or blood vessels [36].…”
Section: Differentiation Of Human Embryonic Stem Cellsmentioning
confidence: 99%