Hematopoietic growth factors in lung cancer

Genova, Carlo; Rijavec, Erika; Grossi, Francesco

doi:10.1097/cco.0000000000000268

Cited by 7 publications

(5 citation statements)

References 78 publications

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“…Their subjects were in or after anti-tumor therapy. Chemotherapy causes myelosuppression [ 19 ] and surgery leads to blood loss, which increases anemia rates. Pretreatment of anemia can improve the overall survival rate of lung cancer and control disease progression [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Serum ferritin and primary lung cancer

Chen

Zhu

et al. 2017

Oncotarget

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Existing research yields conflicting results regarding the relation between iron deficiency and high serum ferritin (SF) levels in primary lung cancer patients. We investigated the concentrations of SF, hemoglobin (Hb) and transferrin (TRF) in 569 male primary lung cancer patients and 252 female primary lung cancer patients. We grouped the subjects according to gender, smoking status, menopausal status, pathological type, stage, and TNM stage. The levels of SF and TRF were correlated with T stage in male patients (p<0.01). The levels of SF and TRF were correlated with menopausal status in female patients (p<0.01). Hb was correlated with smoking status, pathological type, stage, and TNM stages in male patients(p<0.01), but in female patients, Hb was not correlated with these grouping factors(p>0.05). The levels of SF may be regulated by different mechanisms and may be of different physiological significance in different populations.

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Section: Discussionmentioning

confidence: 99%

Serum ferritin and primary lung cancer

Chen

Zhu

et al. 2017

Oncotarget

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“…At present, chemotherapy is still a relatively effective and widely used treatment strategy for malignant tumors. However, due to the serious multi-system toxic and side effects of chemotherapy drugs, it may lead to the decline of immune function and bone marrow hematopoietic dysfunction, thus leading to the interruption of chemotherapy (5,6). The currently used antimyelosuppression drugs are expensive and do not work as well as expected (7-9), so it is very necessary to find inexpensive, safe, and effective anti-myelosuppression drugs.…”

Section: Discussionmentioning

confidence: 99%

“…However, myelosuppression often occurs during chemotherapy for lung cancer patients (4). Chemotherapyinduced myelosuppression, which is often manifested as a decline in white blood cells (WBCs) and a series of hematopoietic dysfunction, is a main obstacle that restricts the progress of chemotherapy (5,6). Therefore, it is important to improve the symptoms of myelosuppression for the insurance of the efficacy of chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Astragaloside IV and Saponins of Rhizoma Polygonati Cure Cyclophosphamide-Induced Myelosuppression in Lung Adenocarcinoma via Down-Regulating miR-142-3p

Zhu

et al. 2021

Front. Oncol.

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Our previous study revealed that Shuanghuang Shengbai granule could cure the myelosuppression induced by cyclophosphamide (CTX) in lung cancer. However, its hematopoietic effects and molecular mechanisms remain not fully understood. Therefore, this study was intended to investigate the effects and the underlying mechanisms of Astragaloside IV (AS) and saponins of rhizoma polygonati (SRP), the two main bioactive ingredients of Shuanghuang Shengbai granule, on CTX-induced myelosuppression. CTX inhibited the proliferation and promoted apoptosis in bone marrow hematopoietic stem cells (BMHSCs), accompanied by the increased expression of miR-142-3p. AS and/or SRP treatment could alleviate CTX-induced cell injury and suppress the expression of miR-142-3p. Over-expression of miR-142-3p partially reversed the therapeutic effect of AS and/or SRP on CTX-induced cell injury in BMHSCs. Further mechanism exploration discovered that HMGB1 was the target gene of miR-142-3p, and miR-142-3p negatively regulated the expression of HMGB1. To further explore the function of AS and/or SRP in vivo, we constructed a lung cancer xenograft combined with CTX-induced myelosuppression mouse model, and we found that AS and SRP remarkably reversed the CTX-induced reduction of white blood cells, bone marrow nucleated cells, and thymus index in vivo and did not affect the chemotherapy effect of lung cancer. Collectively, our results strongly suggested that AS and SRP could improve the hematopoietic function of myelosuppressed lung cancer mice, and their effects may be related to the inhibition of miR-142-3p expression in BMHSCs.

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“…The process of blood cell formation, by which a small number of self-renewing stem cells give rise to lineage committed progenitor cells that subsequently proliferate and differentiate to produce the circulating mature blood cells, is regulated by a series of related hematopoietic related cytokines (Sieff, 1987). Hematopoietic growth factors (HGFs) including EPO, TPO, GM-CSF, and IL-3 are cytokines involved in the regulation of hematopoiesis (Ferretti et al, 2006;Genova et al, 2016). Among them, EPO is a glycoprotein hormone and a major agonist for the production of WBC (Franke et al, 2013).…”

Section: Discussionmentioning

confidence: 99%