Hematopoietic stem cell mobilization into the peripheral circulation in patients with chronic liver diseases

Abstract

Various degrees of severity in CLD neither evoked the mobilization of BMHSC into the circulation nor triggered their homing into liver tissue, thus excluding extrahepatic stem cell-mediated repair. The recovery process seems to be dependent on proliferating endogenous liver progenitors (OV6(+) cells).

Molecular and functional characterization of CD133 + stem/progenitor cells infused in patients with end-stage liver disease reveals their interplay with stromal liver cells

“…Here, we demonstrated that ESLD patients show basal levels of circulating hematopoietic and endothelial progenitors comparable with those detected in healthy donors. Consistent with a previous study, patients with chronic cirrhosis had similar numbers of circulating CD133 + /CD34 + cells compared with healthy people [47]. This finding indicates that severe chronic liver injury, by itself, probably does not stimulate mobilization of BM-derived cells into PB.…”

Concise review: Bone marrow autotransplants for liver disease?

“…Chronic liver failure itself probably does not stimulate mobilization of bone marrow cells into the blood. In a recent study, persons with chronic cirrhosis had similar numbers of blood CD133 + /CD34 + cells as normals .…”

Splenectomy increases the number of circulating hematopoietic stem/progenitor cells in patients with hepatitis C virus‐associated liver cirrhosis

“…However, in previous reports, there were no significant differences in the percentage of HSC among patients with LC. 9,27 It is well known that the number of leukocytes in the PB decreases significantly with disease progression in patients with CLD. 18,19 Therefore, even if there is no difference of the percentage of CD34 + cells among patients with CLD, the absolute number of these cells is thought to decrease with the progression of liver disease.…”