Hematopoietic Stem Cell Transplantation in Egypt Challenges and Solutions

Mahmoud, Hossam K.; Fathy, Gamaleldin M; Elhaddad, Alaa; Fahmy, Omar; Abdel-Mooti, Mohamed; Abdelfattah, Raafat; Bokhary, Mahmoud

doi:10.4084/mjhid.2020.023

Cited by 13 publications

(12 citation statements)

References 43 publications

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“…Therefore, it is expected that finding a HLA matched family member donor will be much more likely. Indeed, the rate of HLA matched related donor transplantation is approximately 30% which is similar to the worldwide experience (Koopmans et al 2003 ; Mahmoud 2020 ; Yurdakul and Beksaç 2019 ; Fumimaro Takaku1 on behalf of JMDP 2018 ; Kollman et al 2001 ; Stanworth et al 2001 ; Gratwohl et al 1996 ).…”

Section: Introductıonsupporting

confidence: 70%

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Blood and bone marrow donor registry of Istanbul medical faculty activity and experience in past 3 years

et al. 2021

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Allogeneic stem cell transplantation (SCT) offers a potential cure for some hematological malignancies. For those patients without a family donor, unrelated donor (MUD) registries serve for identifying the best donor. In the present study, we aimed to give a cross-sectional report of our registry's activity and experience as the first established national MUD registry in the country. The study is retrospective and covers the period of 2016 to 2019. A total of 1855 donor searches were performed, and 642 were included in the study. All data were electronically obtained from the institutional database system. All SCTs were either 10/10 or 9/10 HLA matched and originated from an international registry. The most preferred stem cell source was peripheral blood (70.2%). A quarter of transplants were performed using bone marrow, and cord blood was used with a rate of 1.4%. The pandemic-related problems were similar for the other two national registries. During the pandemic, 71 of 432 patients who were searched for donors underwent stem cell transplant(SCT). The low number was related mostly with postponing of SCTs and/also difficulties in continuing of volunteering and in achievement of stem cells from international registry. During the Covid19 pandemic, the SCT activity of centers decreased according to the national, and international guidelines. The study revealed an organized, and multidirectional capacity of the registry and also the adaptation to unpredicted conditions such as pandemic. On the other hand, there is a need for more effective strategies for donor recruitment and retention programme.

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Section: Introductıonsupporting

confidence: 70%

“…Allogeneic stem cell transplantation (ASCT) is a therapeutic modality for various diseases, particularly for hematological malignancies (Koopmans et al 2003 ; Mahmoud 2020 ). It is well established that the success of ASCT correlates with Human Leukocyte Antigen (HLA) matching between the stem cell donor, and patient.…”

Section: Introductıonmentioning

confidence: 99%

Blood and bone marrow donor registry of Istanbul medical faculty activity and experience in past 3 years

et al. 2021

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“…This modest outcome, despite the fact that patients had been transplanted with an MRD <0.01%, suggests the need for more sensitive methods, besides flowcytometry, to more 'deeply' detect Allogeneic-HSCT has a definitive curative role in many hematological malignancies. However, in developing countries with limited resources many limitations exist that reflect on the management and outcome of HSCT (41). The importance of this study lies in the fact that it describes the practice and the outcome of HSCT for pediatric ALL patients in a developing country.…”

Section: Discussionmentioning

confidence: 99%

Hematopoietic stem cell transplantation from HLA-matched sibling donors in children with acute lymphoblastic leukemia: A report from the Children’s Cancer Hospital Egypt

et al. 2022

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IntroductionAllogeneic hematopoietic stem cell transplantation (HSCT) is widely used for high-risk acute lymphoblastic leukemia (ALL) patients in their first complete remission (CR1), and for relapsed patients in second complete remission (CR2).Patients and methodsWe retrospectively analyzed data for 67 children with ALL, from a cancer center in a low/middle income country, who had undergone HSCT from human leukocyte antigen (HLA)-matched sibling donors (MSDs) using myeloablative conditioning (MAC) regimens, between 2007 and 2020, describing the survival outcome and relapse probability after achieving CR1 and CR2 and determining outcome differences in relation to indications for HSCT in patients transplanted in CR1. All patients had achieved a negative minimal residual disease prior to transplant (<0.01%).ResultsForty-six patients (68.7%) were in CR1; 25 had adverse cytogenetics, including 18 patients with Philadelphia chromosome-positive ALL (Ph-positive ALL), and 21 had poor induction response. The 5-year overall survival (OS), event-free survival (EFS) and cumulative incidence of relapse (CIR) for the whole cohort were 56.1% (95% CI, 42.8%-69.4%), 49% (95% CI, 35.7%-62.3%) and 33.5% (95% CI, 21.7%-45.8%), respectively with better EFS and CIR for CR1 transplants compared to CR2 transplants (P=0.02 and P=0.03, respectively). Patients with Ph-positive ALL had better 5-year OS, EFS and non-relapse mortality (NRM) compared with other CR1 transplants (P=0.015, P=0.009 and P=0.028, respectively).ConclusionHematopoietic stem cell transplantation from MSD for ALL in CR1 group had superior outcomes compared to CR2 group and was apparently a curable option for Ph-positive ALL without an increased risk of non-relapse mortality. Poorer survival rates and higher relapse probabilities were associated with HSCT conducted to patients who had a poor response to induction therapy or suffered a relapse.

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“…In 1997, the rate of transplantation increased significantly. 6 Specific attention has developed towards educating the longterm survivors and their caregivers in which nursing intervention plays a significant role because medical treatment activities are more in the background and dayto-day questions have to be dealt with. ¹…”

Section: Introductionmentioning

confidence: 99%

Nursing Intervention for Caregivers of Post Autologous Bone Marrow Transplantation Patients at Home

Mohamed¹,

Soliman²,

El-Sayied³

et al. 2021

IJFMT

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Background: Autologous bone marrow transplantation is a curative procedure for hematological diseases and immune deficiencies. The unique and intensive nature of this treatment requires distinctive care during and post the entire transplant course. Nursing intervention for caregivers post autologous bone marrow transplantation patients at home is an important component of the care that improves and develops knowledge and practice of the caregivers, to take care of the patients in order to help them follow the demanding treatment plan to reach recovery. Aim to evaluate the effect of nursing intervention for caregivers of postautologous bone marrow transplantation patients at home. Material and Method: A Quasi-experimental study was carried out among convenient sample of 143 patients and their caregivers who attended the follow up clinic during the first six months post autologous bone marrow transplantation. The study was conducted among patients and their caregivers in three different hospitals Sheikh Zayed Specialized Hospital, National oncology institute, and Nasser institute at outpatient's follow-up clinics. A self-administered questionnaire of patients and their caregivers' demographic data, and reported checklist of caregivers' knowledge and practices toward post-autologous bone marrow transplantation patients at home. Results: there was a statistically significant difference between pre and post nursing intervention, which indicate improvement in caregivers' knowledge and practice post implementation of the nursing intervention program, and positive correlation between their knowledge and practice. Conclusion and Recommendations: Although caregivers had adequate knowledge, practice on some aspects, gaps were identified. There is a need for educational interventions and discharge plan to upgrade knowledge and practices of the caregivers of post autologous bone marrow transplantation patient at home.

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Hematopoietic Stem Cell Transplantation in Egypt Challenges and Solutions

Cited by 13 publications

References 43 publications

Blood and bone marrow donor registry of Istanbul medical faculty activity and experience in past 3 years

Blood and bone marrow donor registry of Istanbul medical faculty activity and experience in past 3 years

Hematopoietic stem cell transplantation from HLA-matched sibling donors in children with acute lymphoblastic leukemia: A report from the Children’s Cancer Hospital Egypt

Nursing Intervention for Caregivers of Post Autologous Bone Marrow Transplantation Patients at Home

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