Hematoprotective effects and antioxidant properties of β-glucan and vitamin C against acetaminophen-induced toxicity: an experimental study in rats

Matić, Miloš; Paunović, Milica G.; Milošević, Marija; Ognjanović, Branka I.; Saičić, Zorica S.

doi:10.1080/01480545.2019.1587451

Cited by 9 publications

(5 citation statements)

References 34 publications

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“…Our results indicated that APAP administration altered CAT activity in the livers of mice. These findings are consistent with prior research, which found that APAP exposure causes lipid peroxidation and changes the antioxidant state (36). This change could be due to decreased enzyme production or oxidative inactivation of enzymes.…”

Section: Oxidative Stress Typically Modifies the Antioxidantsupporting

confidence: 93%

Preventive and Therapeutic Effects of Epicatechin on Acetaminophen-Induced Liver Injury in Mice

Dehbashi,

Zeidooni,

Mansouri

et al. 2023

Jundishapur J Nat Pharm Prod

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Background: Nowadays, the use of over-the-counter drugs such as acetaminophen (APAP) may cause severe liver injury, which can occur not only in high doses but also in therapeutic doses due to nutritional deficiency, alcoholism, or using cytochrome p450 inducers. Objectives: In this study, the protective effect of epicatechin (EPC) was evaluated against APAP-induced hepatotoxicity to find an effective and inexpensive therapy. Methods: The animals were divided into preventive and therapeutic groups. In the preventive study, the animals received EPC (25, 50, and 100 mg/kg/day) for five days, and the last dose was administered 1 hour before APAP (400 mg/kg). In the therapeutic groups, the animals received EPC just before and 2 hours after the APAP injection. All the animals were killed, and blood and liver samples were taken for further analysis. The liver pathology, enzymes, and oxidant, antioxidant, inflammatory, and anti-inflammatory factors were evaluated. Results: EPC significantly decreased the serum activity level of the liver biomarkers ALT and AST in the APAP-treated mice. Furthermore, the hepatic levels of thiobarbituric acid-reactive substances were noticeably lowered, and the levels of total thiol and catalase activity increased significantly with EPC. Histopathological results were strongly consistent with those of the biochemical estimations. The most effective dose was observed at EPC 100 mg/kg, and the therapeutic groups showed better results than the preventive groups. Conclusions: EPC attenuated the liver toxicity in the mice by suppressing oxidative stress and can be considered a preventive and therapeutic agent for inhibiting and resolving the liver damage induced by APAP.

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Section: Oxidative Stress Typically Modifies the Antioxidantsupporting

confidence: 93%

Preventive and Therapeutic Effects of Epicatechin on Acetaminophen-Induced Liver Injury in Mice

Dehbashi,

Zeidooni,

Mansouri

et al. 2023

Jundishapur J Nat Pharm Prod

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“…Therefore it was presumed that APAP increases the degradation rate of erythrocytes. The rise in WBCs seen in the APAP-treated rats is consistent with the result of Matić et al (2021) and that may be an indicator to acute inflammation. The harmful effects were reduced by allicin and/or omega3 treatment, which returned changes in the haematological parameters to the recorded values in the control group.…”

Section: Discussionsupporting

confidence: 82%

Protective effect of allicin and omega-3 against paracetamol induced hepatic toxicity

Elsafty

Abdeen

Aboubakr

2022

Benha Veterinary Medical Journal

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The most prominent over-the-counter antipyretic-analgesic drug is paracetamol (n-Acetyl-Para-Amino-Phenol, APAP). This study attempted to examine whether allicin (AC) and/or Omega-3 fatty acids (O3FA) could protect rats from the liver damage induced by APAP. Seventy rats were randomly distributed into seven groups (n=10): Control (saline), AC group received allicin (10 mg/kg, PO), O3FA group given omega-3 (100 mg/kg, PO), APAP group given paracetamol (1000 mg/kg, PO single dose on the 27th day), AC+APAP group received AC (10mg/kg) for 30 days and then given single dose of paracetamol on the 27th day (1000 mg/kg, PO), O3FA+APAP group received O3FA (100 mg/kg) for 30 days and then given single dose of paracetamol on the 27th day (1000 mg/kg, PO), and AC+O3FA+APAP group received O3FA (100 mg/kg) and AC (10 mg/kg) for 30 days and then given single dose of paracetamol on the 27th day (1000 mg/kg, PO). APAP had a significant negative impact on haematological and serum biochemical markers suggested that hepatic injury occurred in response to the APAP exposure. Histopathological examination of liver sections confirmed this hepatic damage where hepatic denegeration and necrosis were evident after APAP treatment. Allicin and/or omega 3 fatty acids treatment restore hepatic tissue architecture after treatment. Thus, pre-treatment with AC and O3FA alone or in combination was effective to reduce hepatic injury in APAP-intoxicated rats.

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“…The most frequently evaluated parameters in liver damage are serum ALT and AST levels (Ferah et al 2013, Liang et al 2015. Pretreatment with GOS before the toxic APAP dose increased ALT and AST levels in the plasma due to liver toxicity induced by APAP, showing that APAP causes liver dysfunction, in line with previous studies (Golestan Jahromi et al 2010, Matic et al 2021. Treatment of mice with GOS or NAC reduced the level of AST and ALT and hence reduced liver toxicity.…”

Section: Discussionsupporting

confidence: 82%

Effects of gossypin on acetaminophen-induced hepatotoxicity in mice

Çınar,

Yayla,

Toktay

et al. 2024

Trakya University Journal of Natural Sciences

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Liver injury from paracetamol (acetaminophen) (APAP) is common worldwide. To prevent intoxication with a drug with high poisoning, treatment can be made possible with an easily accessible and harmless substance. This study aimed to investigate the hepatoprotective ef-fects of Gossypin (GOS) in mice exposed to an overdose of APAP -the possible mechanism of action. Specifically, serum [alanine aminotransferase (ALT), aspartate transaminase (AST), and hepatic biochemical parameters (glutathione (GSH), malondialdehyde (MDA) and super-oxide dismutase (SOD)] were evaluated. Protein and mRNA levels of inflammatory, apoptot-ic, and cytochrome factors, including TNF-α, IL-1β, IL-6, NF-kB, and CYP2E1, were ana-lyzed using real-time PCR. Pretreatment with GOS significantly reduced APAP-induced he-patic injury via oxidative stress. Along with potent antioxidant activity, GOS promoted APAP hepatic detoxification by regulating AST, ALT, GSH, MDA, and SOD activities and mRNA levels of the cytochrome CYP2E1 gene. The anti-inflammatory activity of GOS in-creases its production. TNF-α, IL-1β and IL-6, through possible NF-kB blockade, are also responsible for its hepatoprotective effect. Taken together, GOS has the potential to be devel-oped as a preventive agent to be administered to patients suffering from APAP overdose.

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Hematoprotective effects and antioxidant properties of β-glucan and vitamin C against acetaminophen-induced toxicity: an experimental study in rats

Cited by 9 publications

References 34 publications

Preventive and Therapeutic Effects of Epicatechin on Acetaminophen-Induced Liver Injury in Mice

Preventive and Therapeutic Effects of Epicatechin on Acetaminophen-Induced Liver Injury in Mice

Protective effect of allicin and omega-3 against paracetamol induced hepatic toxicity

Effects of gossypin on acetaminophen-induced hepatotoxicity in mice

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