2007
DOI: 10.1021/bi7009585
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Heme Binding Properties of Staphylococcus aureus IsdE

Abstract: Staphylococcus aureus is the source of a large number of hospital-acquired infections, of which many are serious and can lead to death. Iron is critically important to the survival and growth of the bacterium, and complex, multistep mechanisms are present to fulfill the necessary iron requirement. Isd proteins located on the wall and membrane of S. aureus have been proposed to function in heme acquisition. We report characterization of the S. aureus heme-binding protein IsdE, the lipoprotein component of a mem… Show more

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Cited by 34 publications
(39 citation statements)
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“…In Fig. 1, the lack of changes in charge state distribution between the apo-and holo-species for NEAT-B2, and NEAT-C, in addition to the data previously published for IsdE (28), indicates that no significant structural changes take place with heme binding in any of these proteins. The ESI-MS data in Fig.…”
Section: Esi-ms As a Methods To Discriminate Apo From Holo Isdsupporting
confidence: 67%
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“…In Fig. 1, the lack of changes in charge state distribution between the apo-and holo-species for NEAT-B2, and NEAT-C, in addition to the data previously published for IsdE (28), indicates that no significant structural changes take place with heme binding in any of these proteins. The ESI-MS data in Fig.…”
Section: Esi-ms As a Methods To Discriminate Apo From Holo Isdsupporting
confidence: 67%
“…7 also clearly show that no heme transfer took place and that the solution after mixing contains only holo-NEAT-A and apo-IsdE. (28) form and purified. Holo-proteins were prepared by reconstitution of apo-proteins with hemin.…”
Section: Esi-ms As a Methods To Discriminate Apo From Holo Isdmentioning
confidence: 77%
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