Heme Iron Concentrate and Iron Sulfate Added to Chocolate Biscuits: Effects on Hematological Indices of Mexican Schoolchildren

Quintero-Gutiérrez, Adrián Guillermo; González-Rosendo, Guillermina; Pozo, Javier Polo; Sanchez, J.

doi:10.1080/07315724.2015.1060875

Cited by 7 publications

(3 citation statements)

References 25 publications

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“…This may be due to the fact that participants may have increased their intake of Fe-containing foods after being informed of their Fe-deficient status following screening but before they commenced the study. Despite reduction in the placebo group, the present study also demonstrated the effectiveness of Fe-fortified breakfast cereal (irrespective of vitamin D intervention) on raising principal Fe biomarkers which is in agreement with the recent findings ( 31 – 34 ) .…”

Section: Discussionsupporting

confidence: 93%

Vitamin D₃ supplementation for 8 weeks leads to improved haematological status following the consumption of an iron-fortified breakfast cereal: a double-blind randomised controlled trial in iron-deficient women

Fuzi

Mushtaq

2019

Br J Nutr

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The effect of 38 µg (1500 IU) daily vitamin D3 supplementation, consumed with an Fe-fortified breakfast cereal for 8 weeks, on haematological indicators in Fe-deficient female subjects was investigated. Fifty Fe-deficient subjects (plasma ferritin concentration <20 µg/l; mean age: 27·4 (sd 9·4) years) were randomised to consume an Fe-fortified breakfast cereal containing 9 mg of Fe daily, with either a vitamin D3 supplement or placebo. Blood samples were collected at baseline, interim (4 weeks) and post-intervention (8 weeks) for measurement of Fe and vitamin D status biomarkers. The effect of intervention was analysed using mixed-model repeated-measures ANOVA. Significant increases were observed in two main haematological indices: Hb concentration and haematocrit level from baseline to post-intervention in the vitamin D group but not in the placebo group. The increase from baseline to post-intervention in Hb concentration in the vitamin D group (135 (sd 11) to 138 (sd 10) g/l) was significantly higher compared with the placebo group (131 (sd 15) to 128 (sd 13) g/l) (P=0·037). The increase in haematocrit level from baseline to post-intervention was also significantly higher in the vitamin D group (42·0 (sd 3·0) to 43·8 (sd 3·4) %) compared with the placebo group (41·2 (sd 4·3) to 40·7 (sd 3·6) %) (P=0·032). Despite the non-significant changes in plasma ferritin concentration, this study demonstrates that 38 µg supplemental vitamin D, consumed daily, with Fe-fortified breakfast cereal led to improvement in Hb concentration and haematocrit levels in women with low Fe stores. These findings may have therapeutic implications in the recovery of Fe status in Fe-deficient populations at a healthcare level.

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Section: Discussionsupporting

confidence: 93%

Vitamin D₃ supplementation for 8 weeks leads to improved haematological status following the consumption of an iron-fortified breakfast cereal: a double-blind randomised controlled trial in iron-deficient women

Fuzi

Mushtaq

2019

Br J Nutr

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“…Hemin is an anti-inflammatory agent with antioxidant effects. It improves anemia, suppresses pulmonary hypertension [ 11 , 12 , 13 , 14 ], and accelerates wound healing in diabetic rats [ 15 ]. In a previous study, we observed peroxidase activity of ferrous hemoglobin that catalyzed the reaction of hydrogen peroxide with tyrosine.…”

Section: Introductionmentioning

confidence: 99%

Hemin with Peroxidase Activity Can Inhibit the Oxidative Damage Induced by Ultraviolet A

Hui

Yang

Fang

et al. 2022

CIMB

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Excessive reactive oxygen species (ROS), a highly reactive substance that contains oxygen, induced by ultraviolet A (UVA) cause oxidative damage to skin. We confirmed that hemin can catalyze the reaction of tyrosine (Tyr) and hydrogen peroxide (H2O2). Catalysis was found to effectively reduce or eliminate oxidative damage to cells induced by H2O2 or UVA. The scavenging effects of hemin for other free-radical ROS were also evaluated through pyrogallol autoxidation, 1,1-diphenyl-2-picrylhydrazyl radical (DPPH·)-scavenging assays, and phenanthroline–Fe2+ assays. The results show that a mixture of hemin and tyrosine exhibits strong scavenging activities for H2O2, superoxide anion (O2−·), DPPH·, and the hydroxyl radical (·OH). Furthermore, the inhibition of oxidative damage to human skin keratinocyte (HaCaT) cells induced by H2O2 or UVA was evaluated. The results show that catalysis can significantly reduce the ratio of cell apoptosis and death and inhibit the release of lactate dehydrogenase (LDH), as well as accumulation of malondialdehyde (MDA). Furthermore, the resistance to apoptosis was found to be enhanced. These results show that the mixture of hemin and tyrosine has a significantly protective effect against oxidative damage to HaCaT cells caused by UVA, suggesting it as a protective agent for combating UVA damage.

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“…When heme iron was used to fortify foods, it resulted in lipid oxidation like many nonheme fortificants [132]. Despite these challenges, biscuits fortified with heme iron have been shown to be equally as effective as biscuits fortified with FeSO4 in increasing hemoglobin in preschool aged children when fed for 10 weeks [133]. Additionally, chocolate flavored biscuits fortified with heme have been reported to be well accepted by adolescent girls and were effective at raising hemoglobin when fed for 13 weeks [134].…”

Section: Heme and Organic Fortificantsmentioning

confidence: 99%

Novel methods for identification and quantification of iron fortificants in cereal flours

Hanson¹

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CHAPTER 2. LITERATURE REVIEW………………………………………………………... 4 Prevalence, Causes, Risk Factors, and Consequences of Iron Deficiency and Anemia… 4 Prevalence of Iron Deficiency and Anemia……………………………………... 4 Causes and Risk Factors of Iron Deficiency and Anemia………………………. 4 iii Interventions……………………………………………………………………………. Iron Supplementation and Home Fortification………………………………… Improved Dietary Diversity……………………………………………………. Biofortification…………………………………………………………………. Iron Fortification………………………………………………………………... Ferrous Fortificants……………………………………………………………... Ferric Fortificants………………………………………………………………. Elemental Iron Fortificants……………………………………………………... Encapsulated Fortificants………………………………………………………. Heme and Organic Fortificants………………………………………………… Methods to Improve Iron Absorption…………………………………………... Existing Methods for Identification and Quantification of Iron Fortificants …………… Conclusions…………………………………………………………………………….. References……………………………………………………………………………....

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Heme Iron Concentrate and Iron Sulfate Added to Chocolate Biscuits: Effects on Hematological Indices of Mexican Schoolchildren

Abstract: Heme iron concentrate and iron sulfate were equally effective in increasing Hb levels and hematological indices. Processed foods were shown to be an effective, valuable, and admissible intervention to prevent anemia in preschool children.

Cited by 7 publications

References 25 publications

Vitamin D₃ supplementation for 8 weeks leads to improved haematological status following the consumption of an iron-fortified breakfast cereal: a double-blind randomised controlled trial in iron-deficient women

Vitamin D₃ supplementation for 8 weeks leads to improved haematological status following the consumption of an iron-fortified breakfast cereal: a double-blind randomised controlled trial in iron-deficient women

Hemin with Peroxidase Activity Can Inhibit the Oxidative Damage Induced by Ultraviolet A

Novel methods for identification and quantification of iron fortificants in cereal flours

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Heme Iron Concentrate and Iron Sulfate Added to Chocolate Biscuits: Effects on Hematological Indices of Mexican Schoolchildren

Abstract: Heme iron concentrate and iron sulfate were equally effective in increasing Hb levels and hematological indices. Processed foods were shown to be an effective, valuable, and admissible intervention to prevent anemia in preschool children.

Cited by 7 publications

References 25 publications

Vitamin D3 supplementation for 8 weeks leads to improved haematological status following the consumption of an iron-fortified breakfast cereal: a double-blind randomised controlled trial in iron-deficient women

Vitamin D3 supplementation for 8 weeks leads to improved haematological status following the consumption of an iron-fortified breakfast cereal: a double-blind randomised controlled trial in iron-deficient women

Hemin with Peroxidase Activity Can Inhibit the Oxidative Damage Induced by Ultraviolet A

Novel methods for identification and quantification of iron fortificants in cereal flours

Contact Info

Product

Resources

About

Vitamin D₃ supplementation for 8 weeks leads to improved haematological status following the consumption of an iron-fortified breakfast cereal: a double-blind randomised controlled trial in iron-deficient women

Vitamin D₃ supplementation for 8 weeks leads to improved haematological status following the consumption of an iron-fortified breakfast cereal: a double-blind randomised controlled trial in iron-deficient women