Heme oxygenase 1 polymorphism, occupational vapor, gas, dust, and fume exposure and chronic
                    obstructive pulmonary disease in a Danish population-based study

Würtz, Else Toft; Brasch‐Andersen, Charlotte; Steffensen, Rudi; Hansen, Jens; Malling, Tine Halsen; Schlünssen, Vivi; Omland, Øyvind

doi:10.5271/sjweh.3846

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…Overall, these mutant in GSTP1 were significantly with increased COPD risk in our study. HO-1 has anti-oxidant role, and the gene is referred as a cytoprotective stress response gene [ 22 ]. A dinucleotide repeat (GT)n sequence regulates the heme-degrading enzyme expression, and the long allele (L) could reduce enzyme activity [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Association between the oxidative stress gene polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis

Zhou,

Zuo,

Chen

et al. 2023

BMC Pulm Med

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Background The association between the oxidative stress gene polymorphism and chronic obstructive pulmonary disease (COPD) risk has been extensively studied but the results have been controversial. This study aimed to investigate the overall association between the oxidative stress gene including glutathione S-transferase (GST), epoxide hydrolase exon (EPHX), superoxide dismutase (SOD), catalase (CAT), cytochrome P450 system (CYP) and heme oxygenase (HO-1) polymorphism and the risk of COPD. Methods We searched the PubMed and EMBASE database to identify studies that investigated the association between the oxidative stress gene polymorphism and risk of COPD. The relevant data were extracted and statistical analyses were performed using the Revman 5.4 and STATA 12 software. Dominant genetic model, recessive model, co-dominant model, heterozygote model, and allele model were analyzed. Venice criteria and publication bias were conducted to access the credibility and reliability. Results In total, 63 publications including 14,733 patients and 50,570 controls were included in the meta-analysis.15 genetic variants of 6 genes were analyzed, and 7 SNPs in GSTP1, CAT, CYP, SOD were first analyses until now. In our study, EPHX T113C C allele, GSTM1 null, GSTT1 null, GSTP1 A313G G and C341T T allele, CYP1A1 MspI C allele, SOD3 A213G G allele and L type in Ho-1 showed increased COPD risk, especially in Asians. T allele in CAT C262T and C allele in SOD2 Val 9 Ala were associated with decreased COPD risk. To avoid high heterogeneity and publications bias, subgroups analysis was performed in accord with HWE and ethnicity. Publication bias was assessed by Begg’s funnel plots and Egger’s test, and no publication bias were found for recessive models. 4 variants were identified with strong levels of epidemiological evidence of associations with the COPD risk. Conclusions Our results confirm that oxidative stress gene polymorphism was associated with COPD risk. These finding can improve human understanding of this disease gene molecular level and enable early intervention and prevention of COPD. Well-designed studies with large sample sizes are essential to clarify the association of these significant variants with the susceptibility to COPD.

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Section: Discussionmentioning

confidence: 99%

Association between the oxidative stress gene polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis

Zhou,

Zuo,

Chen

et al. 2023

BMC Pulm Med

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“…From the genetic point of view, COPD susceptibility to VGDF could be enhanced by AATD, 111 heme oxygenase 1 polymorphism 112 and DNA methylation 113…”

Section: The Role Of Occupational Exposures In Copd Aetiopathogenesismentioning

confidence: 99%

“…109 Endotoxin and betaglucans, usually present in organic dust, may have a role in maintaining chronic inflammation. 110 From the genetic point of view, COPD susceptibility to VGDF could be enhanced by AATD, 111 heme oxygenase 1 polymorphism 112 and DNA methylation. 113 In conclusion, experimental data confirm the role of occupational exposure in the pathogenesis of COPD, especially for inorganic dust, with data emerging on welding fumes, metals and irritants.…”

Section: Population-based Studiesmentioning

confidence: 99%

Occupational COPD—The most under‐recognized occupational lung disease?

Murgia

Gambelunghe

2022

Respirology

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Chronic obstructive pulmonary disease (COPD) is caused by exposure to noxious particles and gases. Smoking is the main risk factor, but other factors are also associated with COPD. Occupational exposure to vapours, gases, dusts and fumes contributes to the development and progression of COPD, accounting for a population attributable fraction of 14%. Workplace pollutants, in particular inorganic dust, can initiate airway damage and inflammation, which are the hallmarks of COPD pathogenesis. Occupational COPD is still underdiagnosed, mainly due to the challenges of assessing the occupational component of the disease in clinical settings, especially if other risk factors are present. There is a need for specific education and training for clinicians, and research with a focus on evaluating the role of occupational exposure in causing COPD. Early diagnosis and identification of occupational causes is very important to prevent further decline in lung function and to reduce the health and socio‐economic burden of COPD. Establishing details of the occupational history by general practitioners or respiratory physicians could help to define the occupational burden of COPD for individual patients, providing the first useful interventions (smoking cessation, best therapeutic management, etc.). Once patients are diagnosed with occupational COPD, there is a wide international variation in access to specialist occupational medicine and public health services, along with limitations in workplace and income support. Therefore, a strong collaboration between primary care physicians, respiratory physicians and occupational medicine specialists is desirable to help manage COPD patients' health and social issues.

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Regulatory roles of NAT10 in airway epithelial cell function and metabolism in pathological conditions

et al. 2022

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Heme oxygenase 1 polymorphism, occupational vapor, gas, dust, and fume exposure and chronic obstructive pulmonary disease in a Danish population-based study

Cited by 5 publications

References 27 publications

Association between the oxidative stress gene polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis

Association between the oxidative stress gene polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis

Occupational COPD—The most under‐recognized occupational lung disease?

Regulatory roles of NAT10 in airway epithelial cell function and metabolism in pathological conditions

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