Heme Oxygenase (HO)‐1 Is Upregulated in the Nasal Mucosa With Allergic Rhinitis

Elhini, Ahmed; Abdelwahab, Soha Abdelkawi; Ikeda, Katsuhisa

doi:10.1097/01.mlg.0000194692.51979.d1

Cited by 17 publications

(17 citation statements)

References 18 publications

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“…However, in Lim's study, the expression of HO-1 in the airways' submucosa was examined by using immunostaining and there were no significant differences in the amount of staining between patients with mild asthma and control subjects [8]. Studies of HO-1 in nasal mucosa of AR were not adequate and excluded from this meta-analysis, although it also found raised expression of HO-1 in AR [9,18].…”

Section: Discussionmentioning

confidence: 92%

A Meta-analysis of the Association of Exhaled Carbon Monoxide on Asthma and Allergic Rhinitis

Zhang

Chen

et al. 2010

Clinic Rev Allerg Immunol

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The objective of this study is to evaluate the effect of exhaled CO (eCO) on the development of asthma and allergic rhinitis (AR) by means of reviewing published literature. The literatures published between January 1997 and December 2008 from the US National Library of Medicine (NLM) Database were obtained according to inclusion criteria. Meta-analysis of randomized controlled trials (RCTs) was performed. CO levels of asthma and AR patients were compared with that of normal controls. HO-1(heme oxygenase-1) expression and effect of corticosteroids on eCO levels were also analyzed. Fifteen studies concerning asthma and four studies concerning AR were included in this analysis. Heterogeneity from different studies was evident (P < 0.0001), so a random-effects model was preferred. The meta-analysis revealed that asthmatic patients had significantly higher levels of eCO compared to normal controls. There was significant difference between asthma and control groups in terms of eCO (combined weighted mean difference (WMD) 1.33 (95% confidence interval 0.72 to 1.95), P < 0.0001), and no significant difference between AR and control (combined WMD 0.93 (95% confidence interval -0.54 to 2.40), P = 0.22). HO-1 expression were also reviewed, asthma group produced greater expression of HO-1 than control group with significant difference (combined standardized mean difference (SMD) 2.98 (95% confidence interval 1.13 to 4.84), P = 0.002). After corticosteroid therapy, significantly different levels of eCO were produced after corticosteroid therapy than did asthma group (combined WMD -1.23 (95% confidence interval -2.43 to -0.03), P = 0.04). The analysis reveals that eCO levels were significantly raised in asthma and it may attribute to high expression of HO-1, but there were no significantly high eCO levels between AR and control groups. Due to sensitivity to corticosteroid inhibition, eCO may be used as a practical marker to detect and monitor exacerbation of asthma.

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Section: Discussionmentioning

confidence: 92%

A Meta-analysis of the Association of Exhaled Carbon Monoxide on Asthma and Allergic Rhinitis

Zhang

Chen

et al. 2010

Clinic Rev Allerg Immunol

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“…Induction of HO-1 expression has had therapeutic effects in a variety of conditions or inflammatory disorders; however, its immunological regulatory function is suspected. Studies have shown that HO-1 affected the biological function of multiple cell types such as dendritic cells, 23,24 regulatory T cells, 9,38 mast cells 27 and macrophages. 2,39 These immunocytes played a critical role in allergic diseases.…”

Section: Discussionmentioning

confidence: 99%

“…(Th2) -mediated allergic diseases [23][24][25][26] and further induction of HO-1 expression could significantly inhibit allergic inflammation. 4,6,22,27,28 Recently, there has been great progress in research into the biological functions of basophils in allergic diseases.…”

Section: M M U N O L O G Y O R I G I N a L A R T I C L Ementioning

confidence: 99%

Heme oxygenase‐1 inhibits basophil maturation and activation but promotes its apoptosis in T helper type 2‐mediated allergic airway inflammation

Zhong¹,

et al. 2016

Immunology

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SummaryThe anti-inflammatory role of heme oxygenase-1 (HO-1) has been studied extensively in many disease models including asthma. Many cell types are anti-inflammatory targets of HO-1, such as dendritic cells and regulatory T cells. In contrast to previous reports that HO-1 had limited effects on basophils, which participate in T helper type 2 immune responses and antigeninduced allergic airway inflammation, we demonstrated in this study, for the first time, that the up-regulation of HO-1 significantly suppressed the maturation of mouse basophils, decreased the expression of CD40, CD80, MHC-II and activation marker CD200R on basophils, blocked DQ-ovalbumin uptake and promoted basophil apoptosis both in vitro and in vivo, leading to the inhibition of T helper type 2 polarization. These effects of HO-1 were mimicked by exogenous carbon monoxide, which is one of the catalytic products of HO-1. Furthermore, adoptive transfer of HO-1-modified basophils reduced ovalbumin-induced allergic airway inflammation. The above effects of HO-1 can be reversed by the HO-1 inhibitor Sn-protoporphyrin IX. Moreover, conditional depletion of basophils accompanying hemin treatment further attenuated airway inflammation compared with the hemin group, indicating that the protective role of HO-1 may involve multiple immune cells. Collectively, our findings demonstrated that HO-1 exerted its anti-inflammatory function through suppression of basophil maturation and activation, but promotion of basophil apoptosis, providing a possible novel therapeutic target in allergic asthma.

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“…10,11 Substances for ROS detoxification were expressed in allergic rhinitis. 12 In this regard, NOX may play an important role in healthy and allergic nasal mucosa and nasal polyps. Nevertheless, there were no data regarding the expression and distribution of the NOX family in healthy and allergic nasal mucosa and nasal polyps.…”

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confidence: 99%

Overexpression of the Superoxide Anion and NADPH Oxidase Isoforms 1 and 4 (NOX1 and NOX4) in Allergic Nasal Mucosa

Moon

Kim

Lee

et al. 2009

Am J Rhinol�Allergy

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Heme Oxygenase (HO)‐1 Is Upregulated in the Nasal Mucosa With Allergic Rhinitis

Abstract: We demonstrated that expression of HO-1, but not HO-2, was upregulated within the nasal tissues in allergic rhinitis inflammation, and understanding the induction of HO-1 expression may provide for better management of allergic rhinitis that involves oxidative stress.

Cited by 17 publications

References 18 publications

A Meta-analysis of the Association of Exhaled Carbon Monoxide on Asthma and Allergic Rhinitis

A Meta-analysis of the Association of Exhaled Carbon Monoxide on Asthma and Allergic Rhinitis

Heme oxygenase‐1 inhibits basophil maturation and activation but promotes its apoptosis in T helper type 2‐mediated allergic airway inflammation

Overexpression of the Superoxide Anion and NADPH Oxidase Isoforms 1 and 4 (NOX1 and NOX4) in Allergic Nasal Mucosa

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