Hemiacidrin:
A Useful Component in the Treatment of Infectious Renal Stones

Wall, Inger; Tiselius, Hans‐Göran; Larsson, Laşse

doi:10.1159/000473388

Cited by 19 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Various in vitro studies examined the effectiveness of citric acid containing solutions on chemolysis of struvite (5,6,(18)(19)(20). Because of different experimen-tal conditions it is impossible to compare the results of these in vitro studies.…”

Section: Discussionmentioning

confidence: 99%

Chemolysis of Struvite Stones by Acidification of Artificial Urine - An in vitro Study

Jacobs

2001

Scandinavian Journal of Urology and Nephrology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Chemolysis of Struvite Stones by Acidification of Artificial Urine - An in vitro Study

Jacobs

2001

Scandinavian Journal of Urology and Nephrology

View full text Add to dashboard Cite

show abstract

“…One patient was treated with open surgery only. Postoperative percuta neous irrigation with a 10% solution of hemiacidrin (Renacidin®) [ 10] was performed in all but 2 of our patients.…”

Section: Methodsmentioning

confidence: 99%

Long-Term Acidification of Urine in Patients Treated for Infected Renal Stones

Wall

Tiselius²

1990

Urol Int

Self Cite

View full text Add to dashboard Cite

The effects of ammonium chloride, methenamine hippurate and ascorbic acid on urinary pH was studied in 14 normal subjects. A statistically significant reduction of urinary pH was recorded with ammonium chloride in daily doses of 1.5 and 3 g, but not with 2g of methenamine hippurate or 1.8 g of ascorbic acid. Long-term treatment with ammonium chloride in doses between 1.5 and 3 g was given to 11 patients in order to reduce the risk of new stone formation or growth of fragments remaining after disintegration of infected renal stones. Biochemical stone analyses showed struvite in 9 of the treated stones, and urine cultures verified the presence of urease-producing bacteria in 10 patients. Apart from ammonium chloride, the patients were treated with antibiotics, in 4 patients continuously and in the others during periods from 2 to 34 months. The patients were followed for an average period of 32 months. No adverse reactions were recorded with the dosage used. Initially, 6 patients were stone-free, whereas 5 had residual stone fragments with a largest diameter ranging from 4 to 20 mm. At follow-up, 2 patients were still stone-free, and of 5 patients with residual fragments 1 showed stable disease and 3 an improved stone situation. In 5 patients, 3 of whom had residual stone fragments, antibiotic treatment had been interrupted without infectious relapse. Our conclusion is that long-term urinary acidification is possible despite residual fragments and that it might be a beneficial therapeutic supplement to patients who have been treated for infected renal stones, particularly if disintegrated stone material resides in the kidney following extracorporeal or percutaneous lithotripsy procedures.

show abstract

“…The advantage of this therapeutic approach is that it can be carried out without anaesthesia and might thus be an attractive option for patients who are unfit for anaesthesia or other surgical procedures [52,53]. The drawbacks are the risk of sepsis, hyperphosphataemia and hypermagnesaemia [54].…”

Section: Infection Stones and Brushite Stonesmentioning

confidence: 99%

Medical therapy for calculus disease

2011

View full text Add to dashboard Cite

What's known on the subject? and What does the study add? Current knowledge on the subject of "medical stone management" is available in fractionated form. This study is a comprehensive and critical review of the literature and provides up-to-date information on the subject in concise and precise manner. The study highlights the role of medical therapy in various aspects of stone management, i.e. clearance of existing calculi by medical dissolution and facilitating expulsion, and prevention of recurrence.Urolithiasis is a common problem with a high recurrence rate. Medical therapy directed to relieve agonizing pain, expulsion of stone, dissolution of uric acid and cystine stone and prevention of recurrence. NSAIDs are superior to opioids for renoureteral colic because their use doesn't induce vomiting and there is lesser requirement of rescue analgesia. In randomized trials, anticholinergics were not found to be beneficial. Alpha blockers, particularly tamsulosin, reduce pain and facilitate expulsion of stone and fragments of stone following extracorporeal shock wave lithotripsy (SWL) and ureterorenoscopic lithotripsy. Potassium citrate helps in chemodissolution of uric acid and cystine stones and is useful in prevention of stone recurrence in general and in those who have undergone SWL or percutaneious nephrolithotomy. Other measures for prevention of stone recurrence include fluid and dietary therapy, counteracting underlying metabolic abnormalities using suitable medications, phytotheurapeutic agents and probiotics. Once the role of nanobacteria is established in genesis of urinary stones, anti-nanobacteria therapy holds the promise of opening new horizons for prevention of urinary stones. KEYWORDS calculus, colic, litholysis, medical expulsive therapy, medical management, probioticsINTRODUCTION Urolithiasis is a painful and costly condition compounded by a high recurrence rate [1][2][3][4]. It affects 5-15% of the population worldwide [5] with the recurrence rate close to 50% over 10 years [6]. It has associated morbidity and contributes to chronic kidney disease and even death. Advancements in the techniques of shock wave lithotripsy (SWL) and endourological procedures have rendered open stone surgery almost obsolete. Medical measures have assumed an important role in overall management of urolithiasis. Several medications [7] and dietary measures [8,9] have been shown to reduce the rate of stone recurrence. Indeed, a meta-analysis of randomized trials showed a 22.6% reduction in risk of stone recurrence with medicinal and dietary therapy [7]. With better understanding of pathophysiology of urinary stone disease, physicochemical character of urine and pharmacophysiology of the ureter, it is possible to treat selected patients with urolithiasis with only medical therapy. Medical measures are undertaken for renal and ureteric colic, medical expulsive therapy (MET) and chemolytic therapy. In a large proportion of patients, stone recurrence can be prevented by targeted medical therapy. Potential measures for pr...

show abstract

Hemiacidrin: A Useful Component in the Treatment of Infectious Renal Stones

Cited by 19 publications

References 14 publications

Chemolysis of Struvite Stones by Acidification of Artificial Urine - An in vitro Study

Chemolysis of Struvite Stones by Acidification of Artificial Urine - An in vitro Study

Long-Term Acidification of Urine in Patients Treated for Infected Renal Stones

Medical therapy for calculus disease

Contact Info

Product

Resources

About