Hemimandibulectomy and therapeutic neck dissection with radiotherapy in the treatment of oral squamous cell carcinoma involving mandible: a critical review of treatment protocol in the years 1994–2004

Hoffmannová, J.; Foltán, René; Vlk, Marek; Šipoš, Michal; Horká, Edita; Pavlíková, Gabriela; Kufa, Roman; Bulík, Oliver; Šedý, Jiří

doi:10.1016/j.ijom.2010.03.010

Cited by 19 publications

(9 citation statements)

References 35 publications

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“…Using the inclusion criteria described in the Methods section, 8 studies remained after further exclusion of those that did not specifically report on oral cavity SCC …”

Section: Resultsmentioning

confidence: 99%

“…The study by Hoffmannová et al shows that 19% of resections had positive margins, defined as “extending the margin of the tumor.” In this study, close margins were defined as “<5 mm” and were found in 11% of cases; and clear margins were described as “>5 mm.” In the article by Koo et al, positive resection margins were found in 7% of cases, but no information on what they considered as “positive margins” was given. Neither data nor descriptions of close and clear resection margins were given.…”

Section: Resultsmentioning

confidence: 99%

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Resection margins in oral cancer surgery: Room for improvement

et al. 2015

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The purpose of this review was to identify publications on resection margins in oral cancer surgery and compare these with the results from 2 Dutch academic medical centers. Eight publications were considered relevant for this study, reporting 30% to 65% inadequate resection margins (ie, positive and close margins), compared to 85% in Dutch centers. However, clinical outcome in terms of overall survival and recurrence seemed comparable. The misleading difference is caused by lack of unanimous margin definition and differences in surgicopathological approaches. This prevents comparison between the centers. Data from Dutch centers showed that inadequate resection margins have a significantly negative effect on local recurrence, regional recurrence, distant metastasis, and overall survival. These results confirm the need for improvement in oral cancer surgery. We underline the need for consistent protocols and optimization of frozen section procedures. We comment on development of optical techniques for intraoperative assessment of resection margins. © 2015 Wiley Periodicals, Inc. Head Neck 38: E2197-E2203, 2016.

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“…Using the inclusion criteria described in the Methods section, 8 studies remained after further exclusion of those that did not specifically report on oral cavity SCC …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Resection margins in oral cancer surgery: Room for improvement

et al. 2015

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“…Lesions occurring in the retromolar trigone, gingiva, hard palate, buccal mucosa extending to sulci or tongue extending to floor of mouth may involve bone of the maxilla and/or the mandible. The prevalence of mandibular bone involvement by OSCC is reported to range from 12% to 56% of cases [4][5][6]. Such patients commonly have severe dysfunction of speech, mastication and/or swallowing.…”

Section: Introductionmentioning

confidence: 99%

Potential molecular targets for inhibiting bone invasion by oral squamous cell carcinoma: a review of mechanisms

Quan

Johnson

Zhou

et al. 2011

Cancer Metastasis Rev

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Bone invasion is a common characteristic of oral squamous cell carcinoma (OSCC), with adverse affects on patient functionality and survival. Recent studies suggest that it is osteoclasts, rather than malignant keratinocytes themselves, which play the major role in facilitating the entry of the tumour into bone, and its progression within bone. Osteoclasts respond to a variety of local signalling pathways, initiated by products of the malignant epithelial cells. In the present review, we firstly introduce the clinical patterns of bone invasion, and then summarise these signalling pathways and their diverse roles in sequential phases of bone invasion. We also review current researches regarding the incidence and mechanisms of distant metastases to bone, and explain briefly the concept of epithelial-mesenchymal transition, which may generate cancer stem cells and initiate the bone invasion. Finally, we discuss more briefly approaches to the diagnosis and management of OSCC patients with bone invasion. With all these studies and some recent discoveries in our own laboratory, an enhanced understanding of bone invasion will be achieved, which should indicate potential molecular targets for future biotherapies.

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“…OSCC cells often penetrate underlying bone, and 12-56% of patients with OSCC present with bone invasion [1]. According to the American Joint Committee on Cancer (AJCC) classi cation, the presence of bone invasion can upstage this type of cancer regardless of tumor size, because bone invasion is a major poor prognostic indicator of OSCC [2][3][4]. However, the molecular mechanism underlying the invasion of adjacent bone by OSCC is not fully understood.…”

Section: Introductionmentioning

confidence: 99%

The Axin2-snail Axis Promotes Bone Invasion by Activating Cancer-associated Fibroblasts in Oral Squamous Cell Carcinoma

Cho

ling

et al. 2020

Preprint

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Background: In bone-invasive oral squamous cell carcinoma (OSCC), cancer-associated fibroblasts (CAFs) infiltrate into bony tissue ahead of OSCC cells. In the present study, we aimed to investigate the role of the Axin2-Snail axis in the biological behavior of CAFs and bone invasion in OSCC.Methods: The clinicopathological significance of Axin2 and Snail expression was investigated by immunohistochemistry in an OSCC cohort containing 217 tissue samples of patients with long-term follow-up. The influence of the Axin2-Snail axis on the biological behavior of OSCC cells and CAFs was further investigated both in vitro and in vivo.Results: Axin2 expression is significantly associated with Snail expression, status of desmoplasia, and bone invasion in patients with OSCC. In multivariate analysis, lymph node metastasis, desmoplasia, Axin2, and Snail expression were independent poor prognostic factors in our cohort. Supportively, OSCC cells demonstrated attenuated oncogenic activity as well as decreased expression of Snail and various cytokines after Axin2 knockdown in vitro. Among the related cytokines, C-C motif chemokine ligand 5 and interleukin 8 have a strong influence on the biological behavior of CAFs in vitro. Moreover, both the desmoplastic reaction and osteolytic lesions in the calvaria were predominantly decreased after Axin2 knockdown in OSCC cells in vivo using BALB/c athymic nude mice xenograft model. Conclusions: Oncogenic activities of the Axin2-Snail axis are not limited to the cancer cells themselves, but rather extend to CAFs by regulation of cytokine-mediated cancer-stromal interaction, with further implications for bone invasion as well as poor prognosis of OSCC.

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Hemimandibulectomy and therapeutic neck dissection with radiotherapy in the treatment of oral squamous cell carcinoma involving mandible: a critical review of treatment protocol in the years 1994–2004

Cited by 19 publications

References 35 publications

Resection margins in oral cancer surgery: Room for improvement

Resection margins in oral cancer surgery: Room for improvement

Potential molecular targets for inhibiting bone invasion by oral squamous cell carcinoma: a review of mechanisms

The Axin2-snail Axis Promotes Bone Invasion by Activating Cancer-associated Fibroblasts in Oral Squamous Cell Carcinoma

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