Hemisphere Differences in Speech-Sound Event-Related Potentials in Intensive Care Neonates

Maitre, Nathalie L.; Slaughter, James C.; Aschner, Judy L.; Key, Alexandra P.

doi:10.1177/0883073813493502

Cited by 14 publications

(25 citation statements)

References 43 publications

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“…Amongst all aspects of poor outcome in preterm infants, language development is commonly impaired (2). Previous studies indicated that infants with poor language performance at school age show abnormalities in electrocortical signals already in the neonatal period (3,6). Mehta et al showed that abnormalities in conventional EEG are present in 64.5% of infants with speech and language impairment (5).…”

Section: Discussionmentioning

confidence: 99%

Amplitude‐integrated electroencephalography shows alterations in children born preterm displaying poor literacy precursor skills

et al. 2019

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Aim To assess whether amplitude‐integrated electroencephalography (aEEG) alterations in the newborn period are associated with poor precursor skills of literacy at five years of age in children born preterm. Methods Between October 2007 and September 2011 248 preterm infants were eligible for the study at Innsbruck Medical University Hospital. aEEG was analysed for dominating background activity, calculation of the percentage of continuous activity, the Burdjalov scoring system, the minimum, mean and maximum amplitude. At the age of five years, we evaluated preterm born children by the Bielefelder screening (BISC) to assess for early diagnosis of reading problems and weak spelling and classified them as normal performers (n = 64) or poor performers (n = 20). Completion of testing was not possible for one infant. Results The minimum amplitude was significantly lower in the poor BISC performance group as compared to the normal BISC performance group at postnatal week two. The percentage of continuous background activity was significantly higher in infants with normal BISC performance than in infants with poor BISC performance at postnatal week three. Conclusion Children with poor developed precursor skills of literacy showed alterations in aEEG signals. The aEEG could be useful in further diagnosing preterm infants at risk for developmental complications.

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Section: Discussionmentioning

confidence: 99%

Amplitude‐integrated electroencephalography shows alterations in children born preterm displaying poor literacy precursor skills

et al. 2019

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“…Auditory enrichment facilitates the development of the auditory cortex and stimulates the progression of neural arborisation and synaptogenesis [2,3]. Evidence from several studies demonstrates that the preterm infant's ability to process cortical signals is a significant factor affecting the development of receptive and expressive language skills [4,5,50].…”

Section: Discussionmentioning

confidence: 99%

“…By 35 weeks, differentiation of phonemes is possible and the fetus can now dis-DOI: 10.1159/000489600 criminate voice and sustain auditory memory [2]. However, for infants born preterm (especially < 28 weeks) this development occurs in the abnormal environment of the neonatal unit, during a critical period of neural arborisation and synaptogenesis [3]. Significant delays have been found in auditory brainstem responses of preterm infants at a term-equivalent age, reflecting atypical brainstem maturation [4].…”

Section: Introductionmentioning

confidence: 99%

“…These include intrinsic factors such as perinatal insults [6][7][8]; gestational age at birth [9][10][11] and altered neurological pathways [3,5]; low birthweight [12][13][14][15][16][17]; disease processes and severity [18][19][20]; genetic and epigenetic factors including sociocultural influences [17,21], language exposure [22][23][24] and developmental interaction [25][26][27][28]; and nosocomially derived factors such as adverse environmental exposures [29,30], sepsis and neurotoxicity from drugs [31,32]. Long-term studies on language outcomes in preterm infants reveal delays in various aspects of receptive and expressive language [13,14], articulation, comprehension [25], oromotor skills and spontaneous speech [33].…”

Section: Introductionmentioning

confidence: 99%

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Language Exposure of Preterm Infants in the Neonatal Unit: A Systematic Review

Best¹,

Bogossian²,

New³

2018

Neonatology

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Background: Elevated sound levels and low language exposures of preterm infants (< 37 weeks) cared for in the neonatal unit contribute to poorer growth, cognition, language and motor outcomes. These delays can have lasting effects on childhood development and continue throughout adult life. Whilst recommendations have been established for appropriate sound exposure levels in neonatal units, very little is known about the optimal level of language exposure. Objectives: To examine the evidence regarding language exposure, both measured (observational) and prescribed (interventional), in preterm infants (< 37 weeks) cared for in neonatal units and to identify optimal exposure levels to promote neurodevelopment. Search Methods: An electronic search of English-language articles with an open date range was conducted in the PubMed, MEDLINE, Joanna Briggs, CINAHL and Cochrane databases and in Google Scholar. The criteria were limited to original research studies of preterm infants (< 37 weeks) in which language was either measured as it naturally occurred in the neonatal unit environment or through a language intervention. Results: The search produced a total of 2,367 articles, 49 of which were related to language. A full-text review of these articles identified 10 eligible studies and 6 studies from reference searches. Conclusions: Preterm infants experience low levels of language exposure and high sound exposures in neonatal units. There is a lack of conclusive evidence to recommend an optimal level of language exposure to support improved neurodevelopmental outcomes in preterm infants. Further research from large, good-quality clinical trials is required before clear direction can be provided to inform clinical practice.

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“…Because speech-sound discrimination is associated with cognitive and communication outcomes in early childhood, 19,20 future studies should examine whether continued administration of caffeine age in the most immature infants would improve cortical processing as it does in the more mature infants.…”

Section: Discussionmentioning

confidence: 99%

Effects of Caffeine Treatment for Apnea of Prematurity on Cortical Speech-Sound Differentiation in Preterm Infants

et al. 2014

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Caffeine, standard treatment for apnea of prematurity, improves brainstem auditory processing. We hypothesized that caffeine also improves cortical differentiation of complex speech sounds. We used event-related potential methodology to measure responses to speech-sound contrasts in 45 intensive care neonates, stratified by cumulative exposure as no-, low-, and high-caffeine groups. Sound differentiation in the low-caffeine group and near-term no-caffeine infants was similar with repeated measures ANOVA controlling for gestational and postnatal age. However, a generalized estimating equation approach demonstrated that, at equivalent postnatal age, differentiation was reduced in the high-caffeine (gestational age 25 weeks) compared to the lowcaffeine group (gestational age 28 weeks), reflecting the importance of maturity at birth (Z=2.77, p<0.006).We conclude that caffeine improves measures of auditory processing associated with improved neurodevelopmental outcomes in preterm infants. However, current usage of caffeine for apnea of prematurity cannot fully compensate for the effects of brain immaturity on speech sound processing.

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Hemisphere Differences in Speech-Sound Event-Related Potentials in Intensive Care Neonates

Cited by 14 publications

References 43 publications

Amplitude‐integrated electroencephalography shows alterations in children born preterm displaying poor literacy precursor skills

Amplitude‐integrated electroencephalography shows alterations in children born preterm displaying poor literacy precursor skills

Language Exposure of Preterm Infants in the Neonatal Unit: A Systematic Review

Effects of Caffeine Treatment for Apnea of Prematurity on Cortical Speech-Sound Differentiation in Preterm Infants

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