Hemispheric Differences in Neural Activation during Gaze Cueing in Autism Spectrum Disorder (ASD) Measured by Magnetoencephalography (MEG)

Lajiness-O’Neill, Renée; Chase, Anthony; Olszewski, Amy K.; Boyle, M. A.; Pawluk, Lesley; Mansour, Alfred; Jacobson, Daniel; Gallaway, M. L.; Lewandowski-Powley, P.; Gorka, B.; Moran, John; Bowyer, Susan M.

doi:10.1007/978-3-642-12197-5_90

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…MEG studies exploring other well-described behavioral phenomena, such as deficits in face and emotion processing [ 47 - 50 ] , have recently been reported following the growth of more unified theories that include components of altered connectivity, an imbalance in excitatory to inhibitory neural transmission, and impaired neural synchrony as fundamental pathophysiological mechanisms of ASD. These preliminary studies have reported findings suggestive of abnormal functional organization, aberrant pathway development, and possible altered hemispheric specialization.…”

Section: Discussionmentioning

confidence: 99%

Neural synchrony examined with magnetoencephalography (MEG) during eye gaze processing in autism spectrum disorders: preliminary findings

Lajiness-O’Neill

Richard

Moran

et al. 2014

J Neurodevelop Disord

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BackgroundGaze processing deficits are a seminal, early, and enduring behavioral deficit in autism spectrum disorder (ASD); however, a comprehensive characterization of the neural processes mediating abnormal gaze processing in ASD has yet to be conducted.MethodsThis study investigated whole-brain patterns of neural synchrony during passive viewing of direct and averted eye gaze in ASD adolescents and young adults (M Age = 16.6) compared to neurotypicals (NT) (M Age = 17.5) while undergoing magnetoencephalography. Coherence between each pair of 54 brain regions within each of three frequency bands (low frequency (0 to 15 Hz), beta (15 to 30 Hz), and low gamma (30 to 45 Hz)) was calculated.ResultsSignificantly higher coherence and synchronization in posterior brain regions (temporo-parietal-occipital) across all frequencies was evident in ASD, particularly within the low 0 to 15 Hz frequency range. Higher coherence in fronto-temporo-parietal regions was noted in NT. A significantly higher number of low frequency cross-hemispheric synchronous connections and a near absence of right intra-hemispheric coherence in the beta frequency band were noted in ASD. Significantly higher low frequency coherent activity in bilateral temporo-parieto-occipital cortical regions and higher gamma band coherence in right temporo-parieto-occipital brain regions during averted gaze was related to more severe symptomology as reported on the Autism Diagnostic Interview-Revised (ADI-R).ConclusionsThe preliminary results suggest a pattern of aberrant connectivity that includes higher low frequency synchronization in posterior cortical regions, lack of long-range right hemispheric beta and gamma coherence, and decreased coherence in fronto-temporo-parietal regions necessary for orienting to shifts in eye gaze in ASD; a critical behavior essential for social communication.

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Section: Discussionmentioning

confidence: 99%

Neural synchrony examined with magnetoencephalography (MEG) during eye gaze processing in autism spectrum disorders: preliminary findings

Lajiness-O’Neill

Richard

Moran

et al. 2014

J Neurodevelop Disord

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“…Tian et al demonstrated a hypothesis that children with ASD showed atypical intrinsic complexity of brain activity and found significant differences in the complexity between individuals with ASD and TD controls in the right hemisphere (Liu et al 2017). In a MEG study, Bowyer et al revealed that during gaze shifts to targets and faces, higher mean amplitudes of MEG signals were observed in ASD in the left occipital and parietal brain regions, while in the controls, higher mean amplitudes were shown in the right inferior temporal and medial orbitofrontal regions (Lajiness-O'Neill et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Altered complexity in resting-state fNIRS signal in autism: a multiscale entropy approach

Zhang¹,

Wen²,

Sun³

et al. 2021

Physiol. Meas.

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Objective. Feature extraction and recognition in brain signal processing is of great significance for understanding the neurological mechanism of autism spectrum disorder (ASD). Resting-state (RS) functional near-infrared spectroscopy measurement provides a way to investigate the possible alteration in ASD-related complexity of resting-state (RS) functional near-infrared spectroscopy (fNIRS) signals and to explore the relationship between brain functional connectivity and complexity. Approach. Using the multiscale entropy (MSE) of fNIRS signals recorded from the bilateral temporal lobes (TLs) on 25 children with ASD and 22 typical development (TD) children, the pattern of brain complexity was assessed for both the ASD and TD groups. Main results. The quantitative analysis of MSE revealed the increased complexity in RS-fNIRS in children with ASD, particularly in the left temporal lobe. The complexity in the RS signal and resting state functional connectivity (RSFC) were also observed to exhibit negative correlation in the medium magnitude. Significance. These results indicated that the MSE might serve as a novel measure for RS-fNIRS signals in characterizing and understanding ASD.

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Neurophysiological Findings From Magnetoencephalography in Autism Spectrum Disorder: a Comprehensive Review

et al. 2014

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Autism spectrum disorder (ASD) is an etiologically and clinically heterogeneous group of neurodevelopmental disorders, diagnosed exclusively by the behavioral phenotype. The neural basis of altered social, communicative, somatosensory, and restricted and repetitive behaviors remains largely unknown. Magnetoencephalography (MEG) provides a vital method of inquiry to identify the neurophysiological mechanisms of ASD, better illuminate etiologically distinct subgroups, understand the developmental trajectories of aberrant connectivity and track outcome. MEG is a neuroimaging methodology that can localize sources of electrical activity within the brain with millisecond resolution by noninvasively measuring the magnetic fields arising from such activity. This review addresses the central MEG findings exploring auditory, visual and somatosensory processing, higher-order/executive functioning, and resting state in individuals with ASD over the past decade and a half. We offer a summary of emerging trends related to neurophysiological alterations, aberrant hemispheric specialization and connectivity, as well as limitations in the literature and recommendations for future MEG investigations.

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Hemispheric Differences in Neural Activation during Gaze Cueing in Autism Spectrum Disorder (ASD) Measured by Magnetoencephalography (MEG)

Cited by 3 publications

References 9 publications

Neural synchrony examined with magnetoencephalography (MEG) during eye gaze processing in autism spectrum disorders: preliminary findings

Neural synchrony examined with magnetoencephalography (MEG) during eye gaze processing in autism spectrum disorders: preliminary findings

Altered complexity in resting-state fNIRS signal in autism: a multiscale entropy approach

Neurophysiological Findings From Magnetoencephalography in Autism Spectrum Disorder: a Comprehensive Review

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