Hemmung der Dünndarmabsorption beim Menschen durch die intestinalen Hormone Sekretin und Cholecystokinin-Pankreozymin

Effect of Secretin and Caerulein on the Absorption of Water, Electrolytes and Glucose from the Jejunum of Dogs

“…CCK inhibited the absorption of water and electrolytes from the jejunum of man and the dog [5,7,9,12], and impure CCK was more active than pure CCK [7], Thus it was suggested that the impurity contained in CCK, such as gastric inhibitory polypeptide might have influenced the experimental re sults [7], Intravenous CCK increased the glu cose absorption in the jejunum of dogs [12], however, it inhibited glucose absorption in the human jejunum [5,7], The reason for this difference is not known. In the present study, caerulein, when it was given alone, did not influence the jejunal absorption of water, sodium, potassium or glucose.…”

“…Previous workers showed that secretin inhibited the absorption of water and elec trolytes or glucose from the jejunum of the rat [2] and man [3][4][5]7], although there have been reports that secretin had no ef fect upon the absorption from the jejunum of the hamster [1] and rat [6,10,11], Se cretin did not reduce jejunal absorption, when it was given in an in vitro system [1], under anesthesia by pentobarbital [6,10,11], or by single intravenous injection [6,10], On the contrary, secretin was effective in reducing absorption when it was given by continuous intravenous infusion to con scious humans [3][4][5]7] and to our sedated dogs. Therefore, it seems that differences in experimental procedure are the reason for the differences in the literature.…”

“…Therefore, it seems that differences in experimental procedure are the reason for the differences in the literature. In studies in which a continuous intravenous infusion of secretin was given, secretin in a dose of 2 CU/kg/h was effective in reducing ab sorption [3][4][5]7]. Secretin in a dose of 1 CU/kg/h inhibited jejunal absorption in our and in another study [4]; however, it was not effective in two other studies [5,7], Exploration of the dose response of je junal absorption to a continuous intrave nous infusion of secretin would clarify the lowest dose of secretin required to reduce absorption in the jejunum.…”

“…Only a small number of studies are available on the effect of secretin or CCK on the absorption of sugars from the small intestine [5,7,[10][11][12]. Therefore, we investigated the effect of secretin and caerulein on jejunal absorption of water, electrolytes and glucose in the dog.…”