Hemocompatibility of polymers for use in vascular endoluminal implants

Ammann, Kaitlyn R.; Hossainy, Syed; Hossainy, Sahir; Slepian, Marvin J.

doi:10.1002/app.51277

Cited by 8 publications

(6 citation statements)

References 48 publications

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“…Mass-dependent hemolytic-behavior of all the tested materials was observed indicating the sensitivity of erythrocytes when in contact with the PLGA-membranes. As previously reported [ 39 , 40 , 41 , 42 , 102 ], synthetic copolymers are hemocompatible under certain circumstances, and it is very important to consider all the parameters when designing implantable constructs. In the present study, MSN-loaded membranes presented slightly higher hemocompatibility compared with the neat, unloaded membranes; however, the differences were not statistically important, probably due to the small loading percentage of hemocompatible MSNs.…”

Section: Discussionmentioning

confidence: 99%

Electrospun PLGA Membranes with Incorporated Moxifloxacin-Loaded Silica-Based Mesoporous Nanocarriers for Periodontal Regeneration

et al. 2022

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Engineered electrospun membranes have emerged as promising materials in guided tissue regeneration, as they provide an appropriate framework for the formation of new functional periodontal tissues. The development of multifunctional local drug delivery systems with sustained release of drugs for prolonged infection control can be used in periodontal surgical interventions to simultaneously prohibit epithelium downgrowth and ensure proper healing and regeneration of damaged periodontal tissues. The aim of the present study was the fabrication of novel composite membranes from PLGA/moxifloxacin-loaded mesoporous nanocarriers through electrospinning and the evaluation of their drug release profiles. The addition of moxifloxacin-loaded mesoporous nanocarriers in PLGA yielded a sustained and prolonged drug release, while maintaining satisfactory mechanical strength. The freshly fabricated membranes were found to be biocompatible at masses less than 1 mg after exposure to healthy erythrocytes. Increase in the amount of polymer led to more uniform fibers with large diameters and pores. The study of the parameters of the electrospinning process indicated that increase in the applied voltage value and rotation speed of the collector led to more uniform fibers with higher diameter and larger pores, suitable for tissue regeneration applications, such as periodontal tissue regeneration.

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Section: Discussionmentioning

confidence: 99%

Electrospun PLGA Membranes with Incorporated Moxifloxacin-Loaded Silica-Based Mesoporous Nanocarriers for Periodontal Regeneration

et al. 2022

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“…Synthetic polymers that have been used in the past that comply with this requirement include poly(lactic acid) (PLA), poly(glycolic acid), and poly(dioxanone), along with various polyurethanes (PU). [20] Another important requirement biomaterials should fulfill is longevity by matching the implant material's mechanical properties with those of the surrounding tissues. [21] The need for such long-lasting materials makes many polymers excellent candidates.…”

Section: Smpsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Smart Biomaterials in Biomedical Applications: Current Advances and Possible Future Directions

Cecen,

Hassan,

et al. 2023

Macromolecular Bioscience

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Smart biomaterials with the capacity to alter their properties in response to an outside stimulus or from within the environment around them have picked up significant attention in the biomedical community. This is primarily due to the interest in applications that may be anticipated from them in a considerable number of dynamic structures and devices. Shape‐memory materials are some of these materials that have been exclusively used for biomedical applications. They exhibit unique structural reconfiguration features they adapt as per the provided environmental conditions and can be designed for their enhanced biocompatibility. Numerous research has focused on these smart biocompatible materials over last few decades to enhance their biomedical applications. Shape‐memory materials play a significant role in biomedicine to meet new surgical and medical devices’ requirements for special features and utility cases. Because of the favorable design variety, different biomedical shape‐memory materials can be developed by modifying their chemical and physical behaviors to accommodate the desired requirements. In this review, we describe recent advances and characteristics of smart biomaterials for biomedical applications. We also discuss their clinical translations in tissue engineering, drug delivery, and medical devices.This article is protected by copyright. All rights reserved

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“…This is particularly problematic as the inflammatory injury response triggered due to damage from the stenting procedure is a major contributor to neointimal hyperplasia . Additionally, the polymers show limited hemocompatibility, which can lead to thrombosis and result in restenosis or embolism, necessitating antiplatelet therapies . Furthermore, the hydrophobic polymers exhibit delayed endothelialization due to limited migration, adhesion, and proliferation of endothelial cells on the surface of the stent .…”

Section: Introductionmentioning

confidence: 99%

“…10 Additionally, the polymers show limited hemocompatibility, which can lead to thrombosis and result in restenosis or embolism, necessitating antiplatelet therapies. 11 Furthermore, the hydrophobic polymers exhibit delayed endothelialization due to limited migration, adhesion, and proliferation of endothelial cells on the surface of the stent. 12 Developing new materials that address the limitations of current stent coatings is required to improve stenting technology and clinical outcomes while reducing reliance on antiplatelet therapies and the associated bleeding risks.…”

Section: ■ Introductionmentioning

confidence: 99%

REDV-Functionalized Recombinant Spider Silk for Next-Generation Coronary Artery Stent Coatings: Hemocompatible, Drug-Eluting, and Endothelial Cell-Specific Materials

Mayer,

Ruhoff,

Chan

et al. 2024

ACS Appl. Mater. Interfaces

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Coronary artery stents are life-saving devices, and millions of these devices are implanted annually to treat coronary heart disease. The current gold standard in treatment is drugeluting stents, which are coated with a biodegradable polymer layer that elutes antiproliferative drugs to prevent restenosis due to neointimal hyperplasia. Stenting is commonly paired with systemic antiplatelet therapy to prevent stent thrombosis. Despite their clinical success, current stents have significant limitations including inducing local inflammation that drives hyperplasia; a lack of hemocompatibility that promotes thrombosis, increasing need for antiplatelet therapy; and limited endothelialization, which is a critical step in the healing process. In this research, we designed a novel material for use as a next-generation coating for drug-eluting stents that addresses the limitations described above. Specifically, we developed a recombinant spider silk material that is functionalized with an REDV cell-adhesive ligand, a peptide motif that promotes specific adhesion of endothelial cells in the cardiovascular environment. We illustrated that this REDV-modified spider silk variant [eADF4(C16)-REDV] is an endothelial-cellspecific material that can promote the formation of a near-confluent endothelium. We additionally performed hemocompatibility assays using human whole blood and demonstrated that spider silk materials exhibit excellent hemocompatibility under both static and flow conditions. Furthermore, we showed that the material displayed slow enzyme-mediated degradation. Finally, we illustrated the ability to load and release the clinically relevant drug everolimus from recombinant spider silk coatings in a quantity and at a rate similar to that of commercial devices. These results support the use of REDV-functionalized recombinant spider silk as a coating for drug-eluting stents.

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Hemocompatibility of polymers for use in vascular endoluminal implants

Cited by 8 publications

References 48 publications

Electrospun PLGA Membranes with Incorporated Moxifloxacin-Loaded Silica-Based Mesoporous Nanocarriers for Periodontal Regeneration

Electrospun PLGA Membranes with Incorporated Moxifloxacin-Loaded Silica-Based Mesoporous Nanocarriers for Periodontal Regeneration

Smart Biomaterials in Biomedical Applications: Current Advances and Possible Future Directions

REDV-Functionalized Recombinant Spider Silk for Next-Generation Coronary Artery Stent Coatings: Hemocompatible, Drug-Eluting, and Endothelial Cell-Specific Materials

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