Hemodiafiltration and High-Flux Hemodialysis with Polyethersulfone Membranes

David, S.; Gerra, D.; Nitti, C. De; Bussolati, Benedetta; Teatini, Ugo; Longhena, Giorgio Romei; Guastoni, Carlo; Bellotti, Nicoletta; Combarnous, François; Tetta, Ciro

doi:10.1159/000067389

Cited by 25 publications

(11 citation statements)

References 8 publications

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“…Polyethersulfone (PES) is a commercially available material with unique properties, making it extremely suitable for fabrication of highly efficient ultrafiltration membranes. PES‐based materials are already used as high‐flux membranes for hemodialysis and hemodiafiltration 3, 4. However, PES is a highly hydrophobic polymer that makes it prone to strong nonspecific interactions with blood plasma proteins.…”

Section: Introductionmentioning

confidence: 99%

In vitro hemocompatibility of albumin–heparin multilayer coatings on polyethersulfone prepared by the layer‐by‐layer technique

Sperling

Houska

Brynda

et al. 2005

J Biomedical Materials Res

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Polyethersulfone foils (PES)--a unique material for blood purification membranes--were coated with a multilayer assembly of heparin (unfractionated or high anticoagulant activity fraction heparin) and albumin (albumin-heparin coatings), or with a multilayer of albumin (albumin coating), using the layer-by-layer technique. The coatings combine advantages of albumin (reduction of nonspecific interactions) and heparin (specific interactions with blood coagulation proteins). The differences between the two heparins, while significant for their biological activity, had only a minor effect on the multilayer assembly with albumin monitored in situ by reflection infrared spectroscopy (FTIR MIRS). Uncoated as well as modified PES surfaces were evaluated using an in vitro assay with freshly drawn, slightly heparinized (1.5 IU heparin/mL) human whole blood. The blood was circulated with a roller pump over the sample surfaces in shear flow across rectangular slit channels ( app. 6 mL/min and 120 s(-1)) for 1.5 h at 37 degrees C. All coatings effectively reduced platelet adhesion and activation according to the PF4 release. The activation of coagulation evaluated as TAT generation was significantly lowered for the coating composed of albumin and high activity heparin. A further beneficial effect of the heparin containing coatings was reduced complement activation as determined by different complement fragments.

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Section: Introductionmentioning

confidence: 99%

In vitro hemocompatibility of albumin–heparin multilayer coatings on polyethersulfone prepared by the layer‐by‐layer technique

Sperling

Houska

Brynda

et al. 2005

J Biomedical Materials Res

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“…PES shows outstanding oxidative, thermal, and hydrolytic stability as well as good mechanical and film‐forming properties. The PES membranes have been widely used in the biomedical fields, such as blood purification, including hemodialysis, hemofiltration, hemodiafiltration, and plasma separation,4–10 and show good blood compatibility. More recently, PES hollow fiber membrane was used as an immunoprotection planar device for subcutaneous xenotransplantation of pancreatic islets in the diabetic rat 11.…”

Section: Introductionmentioning

confidence: 99%

Polyethersulfone dead‐end tube as a scaffold for artificial lacrimal glands in vitro

Liu

Wang

et al. 2006

J Biomed Mater Res

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Polyethersulfone (PES) dead-end tubes were fabricated by means of a phase inversion technique, and then were used as scaffolds for artificial lacrimal glands. The wall of the dead-end tubes could allow nutrients such as ascorbic acid, L-tryptophan, and glucose to pass through, but prevents rat IgG from passing through. Lacrimal acinar epithelial cells of Sprague-Dawley rats were cultured in vitro, and cell-associated secretory component was detected with an immunofluorescence technique to identify the acinar cells. The second passage of the cells showed high degree of cellular differentiation, and was used to seed on the PES tubes. The results showed that the PES tube could support the attachment, the growth, and the proliferation of the rat lacrimal acinar cells. Thus, PES is a substrate for the growth of lacrimal acinar cells and may be a useful scaffolding biomaterial for tissue engineering, such as a scaffold for artificial lacrimal glands.

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“…Semipermeable membranes in fibre and flat configurations, owing to their functional characteristics, such as selective permeability, stability and cytocompatibility are among the most attractive biomaterials for cell culture in biohybrid systems [3][4][5]. Synthetic porous polyethersulfone (PES) membranes have been used in the biomedical field in applications, such as hemodialysis, filtration and ultrafiltration [6,7]. PES membranes could constitute a good mechanical and chemical support for cell adhesion because of their physico-chemical and morphological properties although 0376 few studies have been conducted to determine whether cells grow on PES.…”

Section: Introductionmentioning

confidence: 99%

“…Most of the literature data were from experiments carried out during the first 24 h of culture [3][4][5][6] using collagen as a culture substrate. No study has been performed yet to identify the effects of diclofenac on specific functions of pig hepatocytes exposed continuously to the drug and on their in vitro long-term ability to metabolise diclofenac.…”

Section: Introductionmentioning

confidence: 99%

Polyethersulfone membrane biohybrid system using pig hepatocytes: Effect of diclofenac on cell biotransformation and synthetic functions

Bartolo

Morelli

Giorno

et al. 2006

Journal of Membrane Science

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Hemodiafiltration and High-Flux Hemodialysis with Polyethersulfone Membranes

Cited by 25 publications

References 8 publications

In vitro hemocompatibility of albumin–heparin multilayer coatings on polyethersulfone prepared by the layer‐by‐layer technique

In vitro hemocompatibility of albumin–heparin multilayer coatings on polyethersulfone prepared by the layer‐by‐layer technique

Polyethersulfone dead‐end tube as a scaffold for artificial lacrimal glands in vitro

Polyethersulfone membrane biohybrid system using pig hepatocytes: Effect of diclofenac on cell biotransformation and synthetic functions

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