Hemodialysis Decreases Serum Brain-Derived Neurotrophic Factor Concentration in Humans

Abstract

In the present study we have evaluated the effect of a single hemodialysis session on the brain-derived neurotrophic factor levels in plasma [BDNF](pl) and in serum [BDNF](s) as well as on the plasma isoprostanes concentration [F(2) isoprostanes](pl), plasma total antioxidant capacity (TAC) and plasma cortisol levels in chronic kidney disease patients. Twenty male patients (age 69.8 ± 2.9 years (mean ± SE)) with end-stage renal disease undergoing maintenance hemodialysis on regular dialysis treatment for 15-71 months participated in this study. A single hemodialysis session, lasting 4.2 ± 0.1 h, resulted in a decrease (P = 0.014) in [BDNF](s) by ~42 % (2,574 ± 322 vs. 1,492 ± 327 pg ml(-1)). This was accompanied by an increase (P< 10(-4)) of [F(2)-Isoprostanes](pl) (38 ± 3 vs. 116 ± 16 pg ml(-1)), decrease (P < 10(-4)) in TAC (1,483 ± 41 vs. 983 ± 35 trolox equivalents, μmol l(-1)) and a decrease (P = 0.004) in plasma cortisol level (449.5 ± 101.2 vs. 315.3 ± 196.3 nmol l(-1)). No changes (P > 0.05) in [BDNF](pl) and the platelets count were observed after a single dialysis session. Furthermore, basal [BDNF](s) in the chronic kidney disease patients was significantly lower (P = 0.03) when compared to the age-matched control group (n = 23). We have concluded that the observed decrease in serum BDNF level after hemodialysis accompanied by elevated [F(2)-Isoprostanes](pl) and decreased plasma TAC might be caused by enhanced oxidative stress induced by hemodialysis.

Substance P and intensity of pruritus in hemodialysis and peritoneal dialysis patients

“…No changes in this neuropeptide level have been observed after a single hemodialysis session [48]. We have not found any studies that assessed substance P level in patients on dialysis.…”

Brain-derived neurotrophic factor plasma levels and premature cognitive impairment/dementia in type 2 diabetes

“…It was recently demonstrated that BDNF stimulates the production of prostacyclin in cerebral arteries[25]; it plays an important role in endothelium-dependent relaxation and has also antiplatelet, vasculoprotective, cardioprotective and anti-atherogenic properties[26-28]. Zoladz et al[29] demonstrated that the decrease in serum BDNF levels after hemodialysis is accompanied by elevated levels of F-isoprostanes and decreased plasma total antioxidant capacity, which might be caused by the increase in oxidative stress induced by hemodialysis.…”

The impact of plasma brain‐derived neurotrophic factor concentration and weight gain after kidney transplantation

“…Although some researchers have investigated BDNF levels in end stage renal disease patients and found that hemodialysis session decreased circulating BDNF levels (Marchelek‐Mysliwiec et al, ; Zoladz et al, ), there is little information about the change of peripheral BDNF in patients undergoing significant weight gain after kidney transplant. In our study, we found that the average BDNF level at 12 months after transplant was significantly lower than that at baseline in 27 recipients in the first year of transplant, a result which is consistent with the previously identified BDNF function in energy homeostasis and obesity (Akbarian et al, ; Mou et al, ; Xu & Xie, ).…”

“…Evidence suggests that BDNF is an important effector through which the hypothalamic melanocortin pathway controls body weight in adults (Xu et al, ). Several research groups have investigated BDNF changes in end stage renal disease patients and found that hemodialysis sessions for these patients decreased circulating BDNF levels, which might be caused by enhanced oxidative stress induced by hemodialysis, as compared to matched healthy individuals (Marchelek‐Mysliwiec et al, ; Zoladz et al, ). Still, much is unknown about how circulating BDNF level is involved in energy intake, energy expenditure, and weight change.…”