Hemodialysis for Isopropanol Poisoning

Freireich, A. W.; Cinque, Thomas J.; Xanthaky, Gregory; Landau, David

doi:10.1056/nejm196709282771308

Cited by 34 publications

(5 citation statements)

References 5 publications

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“…Accidental and suicidal ingestion of isopropanol can sometimes be fatal if it goes unrecognized and untreated (Zaman et al 2002). Nevertheless, fatality from isolated isopropyl alcohol toxicity is rare (Freireich et al 1967), but can result from injury due to inebriant effects, such as untreated coma with airway compromise, or rarely, cardiovascular depression and shock following massive ingestion (Clark 2010). Supportive care can avert most morbidity and mortality.…”

Section: Human Poisoningmentioning

confidence: 99%

Toxic Alcohols: Aliphatic Saturated Alcohols

Patočka¹,

Kuča²

2012

MMSL

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SummaryToxic alcohols that clinicians commonly encounter are ethylene glycol, methanol, and isopropanol. Adults ingest these either for suicidal intent or to achieve inebriation, since these substances are readily available and cheaper than alcohol. Nevertheless, assorted alcohols are used very often in many applications and any alcohol can be toxic if ingested in large enough quantities. Toxic alcohols discussed here include all saturated aliphatic alcohols containing from 1 to 6 carbons in their molecules.

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Section: Human Poisoningmentioning

confidence: 99%

Toxic Alcohols: Aliphatic Saturated Alcohols

Patočka¹,

Kuča²

2012

MMSL

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“…Therapy for isopropanol intoxication is primarily supportive, and hemodialysis is an efficient way to remove the alcohol. In a case reported by Freireich et al [8], a 3-hour dialysis lowered plasma isopropanol by approximately 72% without substantially changing plasma acetone (=¡30% decrease). The urinary concentration of both compounds was about equal to the plasma concentration at beginning and end of dialysis.…”

Section: Dr Morrismentioning

confidence: 86%

Severe Metabolic Acidosis in an Intoxicated Patient

et al. 1988

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“…There is, however, no correlation between plasma levels and mortality (King et al, 1970). It has been shown (Freireich et al, 1967;King et al, 1970) that isopropyl alcohol is removed by haemodialysis and presumably also by peritoneal dialysis. The patient in this case received about 9 hr of peritoneal dialysis before she lost consciousness for the second time and it therefore seems unlikely that isopropyl alcohol contributed greatly to her death.…”

Section: Discussionmentioning

confidence: 99%