Hemodialysis membrane prepared from cellulose/<i>N</i>‐methylmorpholine‐<i>N</i>‐oxide solution. I. Effect of membrane preparation conditions on its permeation characteristics

Abe, Yoshihiko; Mochizuki, Akira

doi:10.1002/app.10527

Cited by 44 publications

(36 citation statements)

References 12 publications

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“…It is noted that the traditional viscose and cuprammonium route for producing regenerated cellulose films is technologically complex and requires additional facilities for treating the gaseous and aqueous waste emissions (end-of-pipe technology), which constitutes a growing urgency to develop a new pathway to avoid the complicated current routes and hazardous byproducts (Nues and Peinemann 2001;Klemm et al 2005). Thus, an more environmentally friendly process of cellulose membrane preparation has been developed by using a direct solvent system, N-methylmorpholine-N-oxide (NMMO; Fink et al 2001;Zhang et al 2001;Abe and Mochizuki 2002), but the Lyocell process suffers from uncontrolled thermal stability of the system NMMO-cellulose-H 2 O (runaway reaction) and high evaporation costs with energy costs (Fink et al 2001;Zhang et al 2001;Abe and Mochizuki 2002). So far, there has been a lack of a simple and low-cost method for the preparation of regenerated cellulose membrane.…”

Section: Introductionmentioning

confidence: 99%

Influence of coagulation temperature on pore size and properties of cellulose membranes prepared from NaOH–urea aqueous solution

2007

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The morphology and structure of the regenerated cellulose membranes prepared from its NaOH-urea aqueous solution by coagulating with 5 wt% H 2 SO 4 -10 wt% Na 2 SO 4 aqueous solution with different temperatures and times were investigated. The pore size, water permeability and physical properties of the membranes were measured with scanning electron micrograph (SEM), wide X-ray diffraction (WXRD), Fourier transfer infrared spectroscopy (FTIR), flow rate method, and tensile testing. The SEM observation revealed that the structure and pore size of the membranes changed drastically as a function of the coagulation temperature. The membranes coagulated at lower temperatures tended to form the relatively small pore size than those at higher temperatures. On the contrary, the membranes coagulated at different times exhibited similar pore size. Interestingly, the mean pore size and water permeability of the membranes increased from 110 nm with standard deviation (SD) of 25 nm and 12 ml h -1 m -2 mmHg -1 respectively to 1,230 nm with SD of 180 nm and 43 ml h -1 m -2 mmHg -1 with an increase in coagulation temperature from 10 to 60°C. However, the membranes regenerated below 20°C exhibited the dense structure as well as good tensile strength and elongation at break. The result from FTIR and ultraviolet-visible (UV-vis) spectroscopy indicated that the relatively strong intermolecular hydrogen bonds exist in the cellulose membranes prepared at lower coagulation temperatures. This work provided a promising way to prepare cellulose materials with different pore sizes and physical properties by controlling the coagulation temperature.

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Section: Introductionmentioning

confidence: 99%

Influence of coagulation temperature on pore size and properties of cellulose membranes prepared from NaOH–urea aqueous solution

2007

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“…The effective membrane area available for ultrafiltration experiments is 38.5 cm 2 . The pure water flux was measured at 37°C at an operating pressure of 250 mmHg [17].…”

Section: Ultrafiltration Rate (Ufr)mentioning

confidence: 99%

“…The solute concentrations in the respective compartments were determined by the Urea Nitrogen (Diacteyl) Reagent method for urea, the Jaffe' method for creatinine, and vitamin B 12 analysis by spectrophotometric at 360 nm for (U-2001, Hitachi Co., Ltd., Tokyo, Japan). The apparent diffusive solute permeability (Pm) of the PSf/PEI blend membranes was calculated as follows [17].…”

Section: Solute Permeability Studiesmentioning

confidence: 99%

Preparation and performance evaluation of poly (ether-imide) incorporated polysulfone hemodialysis membranes

et al. 2012

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Biocompatible Polysulfone (PSf) hemodialysis membranes were prepared by phase inversion technique using poly (ether-imide) (PEI) as the modification agent and Polyethylene glycol (PEG-200) as the pore former. The effect of PSf/PEI blend ratio on the morphology, hydrophilicity, water content, porosity, glass transition temperature, mechanical strength, biocompatibility and permeation rate of the prepared membranes were studied and were found to be improved significantly by the incorporation of PEI in the dope solution. The scanning electron microscopy (SEM) studies revealed that, incorporation of PEI resulted in the formation of spongy sub-layer and increased the connectivity of pores between sub-layer and bottom layer. The water content and permeation rate of the membranes of PSf/ PEI blend membranes were increased considerably indicating the enhancement of hydrophilicity and it was supported by lower contact angle values of the blend membranes. The existence of single well defined Tg over entire composition established the compatibility between the components in blend membranes. The biocompatibility of membranes was investigated through protein adsorption, platelet adhesion and thrombus formation on the membrane surface. Anticoagulant activity of PSf/PEI blend membranes was evaluated by measuring the activated partial thrombin time (APTT), prothrombin time (PT), thrombin time (TT) and fibrinogen time (FT). The results revealed that antithrombogenicity of PSf/PEI blend membranes was increased significantly. The efficiency of these membranes in removal of urea, creatinine and vitamin B 12 were studied and found to be improved for blend membranes. Thus, it is worth mentioning to note that, the biocompatible PSf/PEI blend membranes prepared in this study would offer immense potential in hemodialysis.

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“…In a previous article, 23 we reported the effect of coagulation conditions (coagulant temperature and composition) on the ultrafiltration rate (UFR) and sieving coefficient (SC) of a hemodialysis membrane prepared from an NMMO solution. We concluded that the NMMO solution had a possibility of producing a membrane with high performance when coagulation with low-temperature water was employed.…”

Section: Introductionmentioning

confidence: 99%

Hemodialysis membrane prepared from cellulose/N‐methylmorpholine‐N‐oxide solution. II. Comparative studies on the permeation characteristics of membranes prepared from N‐methylmorpholine‐N‐oxide and cuprammonium solutions

Abe

Mochizuki

2003

J of Applied Polymer Sci

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Two kinds of regenerated cellulose membranes for hemodialysis were prepared from casting solutions of N-methylmorpholine-N-oxide (NMMO) and cuprammonium (denoted NMMO membranes and cuprammonium membranes, respectively). The concentration of cellulose in the casting solution investigated was 6 -8 wt %. The permeation characteristics of both membrane series were compared in terms of the ultrafiltration rate (UFR) of pure water, the sieving coefficient (SC) of dextran, and the solute permeabilities of urea, creatinine, and vitamin B 12 . The UFR and SC of the NMMO membranes were strongly affected by the cellulose concentration of the casting solution, and NMMO was a preferable solvent for the production of cellulose membranes with high performance; the cuprammonium solution gave low-performance membranes. The pore structures of both types of membranes were estimated with the Hagen-Poiseuille law. The results showed that the NMMO membranes had larger pore radius and smaller pore numbers than the cuprammonium membranes. The differences in the membrane pore structures led to the differences in the performance between the two membrane series.

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Hemodialysis membrane prepared from cellulose/N‐methylmorpholine‐N‐oxide solution. I. Effect of membrane preparation conditions on its permeation characteristics

Cited by 44 publications

References 12 publications

Influence of coagulation temperature on pore size and properties of cellulose membranes prepared from NaOH–urea aqueous solution

Influence of coagulation temperature on pore size and properties of cellulose membranes prepared from NaOH–urea aqueous solution

Preparation and performance evaluation of poly (ether-imide) incorporated polysulfone hemodialysis membranes

Hemodialysis membrane prepared from cellulose/N‐methylmorpholine‐N‐oxide solution. II. Comparative studies on the permeation characteristics of membranes prepared from N‐methylmorpholine‐N‐oxide and cuprammonium solutions

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